Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.400 PosttranslationalModification disease BEFREE Complex intrachromosomal rearrangement in the process of amplification of the L-myc gene in small-cell lung cancer. 1312669 1992
CUI: C0035335
Disease: Retinoblastoma
Retinoblastoma 		0.010 Biomarker disease BEFREE These experiments demonstrated that the mutant RB product is capable of binding in vitro to c-myc and L-myc proteins with comparable affinity as wild-type RB. 1334491 1992
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.020 GeneticVariation disease BEFREE Association between restriction fragment length polymorphism of the L-myc gene and lung metastasis in human breast cancer. 1345822 1992
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.020 GeneticVariation disease BEFREE Association between restriction fragment length polymorphism of the L-myc gene and lung metastasis in human breast cancer. 1345822 1992
CUI: C0153676
Disease: Secondary malignant neoplasm of lung
Secondary malignant neoplasm of lung 		0.010 GeneticVariation disease BEFREE Association between restriction fragment length polymorphism of the L-myc gene and lung metastasis in human breast cancer. 1345822 1992
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma 		0.010 GeneticVariation disease BEFREE The combined data for MTCs and pheochromocytomas suggest that the smallest region of overlap of LOH is bounded by D1S15 (1pter-p22) and D1Z2 (1P36.3), excluding a region around MYCL (1p32). 1346584 1992
CUI: C4551683
Disease: Adrenal Gland Pheochromocytoma
Adrenal Gland Pheochromocytoma 		0.010 GeneticVariation disease BEFREE The combined data for MTCs and pheochromocytomas suggest that the smallest region of overlap of LOH is bounded by D1S15 (1pter-p22) and D1Z2 (1P36.3), excluding a region around MYCL (1p32). 1346584 1992
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.100 Biomarker phenotype BEFREE Our results indicate that, in patients with lung cancer, genetic disposition with respect to the L-myc gene influences the extent of metastasis, the incidence of multiple cancers and prognosis. 1347036 1992
CUI: C2314896
Disease: Familial Atypical Mole Melanoma Syndrome
Familial Atypical Mole Melanoma Syndrome 		0.010 GeneticVariation disease BEFREE Exclusion of the familial melanoma locus (MLM) from the PND/D1S47 and MYCL1 regions of chromosome arm 1p in 7 Australian pedigrees. 1531137 1992
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 GeneticVariation group BEFREE Neither c- or L-myc gene amplifications nor K-ras codon 12, 13, 61 point mutations were observed in this tumor. 1622116 1992
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.400 Biomarker disease BEFREE We have recently found the L-myc gene involved in a gene fusion in small-cell lung cancer (SCLC). 1649386 1991
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE The presence of independent genetic lesions that cause the formation of identical chimeric rlf-L-myc proteins suggests a role for the fusion protein in the development of these tumors. 1649386 1991
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.100 GeneticVariation phenotype BEFREE Restriction fragment length polymorphism of the L-myc gene and susceptibility to metastasis in genitourinary cancers. 1683040 1991
CUI: C0751569
Disease: Genitourinary Cancer
Genitourinary Cancer 		0.010 GeneticVariation disease BEFREE Restriction fragment length polymorphism of the L-myc gene and susceptibility to metastasis in genitourinary cancers. 1683040 1991
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.100 Biomarker phenotype BEFREE Two abnormalities showed a significant correlation with clinical course: MYC gene amplification showed an inverse correlation with tumor recurrence (r = -0.44, p = 0.01), and a small increase in MYCL gene copies on chromosome I correlated with the presence of metastases (r = 0.61, p = 0.001). 1777414 1991
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor 		0.020 Biomarker phenotype BEFREE Two abnormalities showed a significant correlation with clinical course: MYC gene amplification showed an inverse correlation with tumor recurrence (r = -0.44, p = 0.01), and a small increase in MYCL gene copies on chromosome I correlated with the presence of metastases (r = 0.61, p = 0.001). 1777414 1991
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.020 Biomarker group BEFREE Two abnormalities showed a significant correlation with clinical course: MYC gene amplification showed an inverse correlation with tumor recurrence (r = -0.44, p = 0.01), and a small increase in MYCL gene copies on chromosome I correlated with the presence of metastases (r = 0.61, p = 0.001). 1777414 1991
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.400 Biomarker disease BEFREE Here two independent small cell lung carcinoma (SCLC) cell lines were found to express similar novel proteins antigenically related to L-myc. cDNAs corresponding to these proteins were cloned and shown to encode chimeric polypeptides with amino-terminal sequences from a novel gene named rlf joined to the L-myc protein. 1851085 1991
CUI: C1261473
Disease: Sarcoma
Sarcoma 		0.010 GeneticVariation group BEFREE Elevated frequency of a specific allele of the L-myc gene in male patients with bone and soft-tissue sarcomas. 1967596 1990
CUI: C4551687
Disease: Sarcoma of soft tissue
Sarcoma of soft tissue 		0.010 GeneticVariation group BEFREE Elevated frequency of a specific allele of the L-myc gene in male patients with bone and soft-tissue sarcomas. 1967596 1990
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth 		0.010 GeneticVariation group BEFREE Restriction fragment length polymorphism of the L-myc gene in oral cancer patients. 1970484 1990
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma 		0.010 GeneticVariation disease BEFREE Restriction fragment length polymorphism of the L-myc gene in oral cancer patients. 1970484 1990
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.080 GeneticVariation disease BEFREE Restriction fragment length polymorphism analysis of the L-myc gene locus in a case-control study of lung cancer. 1975565 1990
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.070 GeneticVariation disease BEFREE Restriction fragment length polymorphism analysis of the L-myc gene locus in a case-control study of lung cancer. 1975565 1990
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.070 GeneticVariation disease BEFREE Restriction fragment length polymorphism analysis of the L-myc gene locus in a case-control study of lung cancer. 1975565 1990