Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.200 Biomarker disease BEFREE BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells. 31754113 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.200 Biomarker disease BEFREE We show that MYC or MYCN amplification in patient-derived glioblastoma stem-like cells (GSCs) generates sensitivity to PARPi via Myc-mediated transcriptional repression of CDK18, while most tumors without amplification are not sensitive. 31266951 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.200 AlteredExpression disease BEFREE TAp63 represses transcription of MYC oncogene in glioblastomas; however, its role in another MYC family gene, MYCN, has remained elusive. 31427086 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.200 AlteredExpression disease BEFREE Here we report that ASCL1 not only promotes the acquisition of a PN phenotype in CSCs by inducing a glial-to-neuronal lineage switch but also concomitantly represses mesenchymal (MES) features by directly downregulating the expression of N-Myc downstream-regulated gene 1 (NDRG1), which we propose as a novel gene classifier of MES GBMs. 30538287 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.200 GeneticVariation disease BEFREE Inhibition of repair processes and comparison of the mouse tumors with human medulloblastomas (n = 68) and glioblastomas (n = 32) identified chromothripsis as associated with MYC/MYCN gains and with DNA repair deficiencies, pointing towards therapeutic opportunities to target DNA repair defects in tumors with complex genomic rearrangements. 30420702 2018
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.200 Biomarker disease BEFREE NAMPT inhibitors were potently cytotoxic, inducing apoptosis and significantly extended the survival of mice bearing MYCN-amplified patient-derived glioblastoma orthotopic xenografts. 27076630 2016
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.200 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.200 Biomarker disease BEFREE We provide the mechanistic explanation for how the fi rst histone gene mutation inhuman disease biology acts to deliver MYCN, a potent tumorigenic initiator, into a stem-cell compartment of the developing forebrain, selectively giving rise to incurable cerebral hemispheric GBM. 23539269 2013
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.200 Biomarker disease BEFREE NDRG2, a member of the N-Myc downstream-regulated gene family, was shown to be a putative tumor suppressor gene in glioblastoma and other cancers. 21912936 2012
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.200 AlteredExpression disease BEFREE This finding also confirms the importance of impairment of the MYC/MAX/MXD1 axis in the development of aggressive neural tumors, because MYCN overexpression is an established genetic hallmark of malign neuroblastoma, and it is likely that MXI1 plays a relevant role in the development of medulloblastoma and glioblastoma. 22706201 2012
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.200 Biomarker disease BEFREE N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation. 12845671 2003
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.200 GeneticVariation disease BEFREE In the glioblastomas with no alterations of CDKN2A, CDK4 or RB1, several other genes (CCND1, CCND2, CCND3, CDK6, E2F, CDK7, MYC and MYCN) whose products take part in cell cycle regulation were examined.No abnormalities were detected. 8806696 1996
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.200 Biomarker disease BEFREE Four genes have been identified as being amplified in more than single cases of glioblastomas; MYCN, GLI, PDGFRA and EGFR. 8448375 1993
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.200 Biomarker disease BEFREE Gene amplification and rearrangements are discussed through review of recent work on the N-myc gene in neuroblastoma and the epidermal growth factor receptor (EGFR) gene in glioblastoma. 3059215 1988