Pneumonia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The apoptosis proteins and the downstream genes of NF-κB pathway were detected by Western blot.<b>Results:</b> we displayed that miR-146b was down-regulated, whereas MyD88 was up-regulated in the serum of children patients with pneumonia and in WI-38 cells treated with LPS.
|
31583932 |
2020 |
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Myeloid differentiation primary response 88 (MyD88) is involved in gram positive bacteria-induced lung inflammation by Toll-like receptors (TLRs).
|
30802676 |
2019 |
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The triggering receptor expressed by myeloid cells-1 activates TLR4-MyD88-NF-κB-dependent signaling to aggravate ventilation-induced lung inflammation and injury in mice.
|
29869715 |
2018 |
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In order to understand how the absence of MyD88 can interfere in the laser effect on lung inflammation, MyD88<sup>-/-</sup> mice were treated or not with laser and subjected to occlusion of the superior mesenteric artery (45 min) followed by intestinal reperfusion (4 h).
|
27924419 |
2017 |
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Comparing efficacies of phage-curative and prophylactic treatments in healthy immunocompetent, MyD88-deficient, lymphocyte-deficient, and neutrophil-depleted murine hosts revealed that neutrophil-phage synergy is essential for the resolution of pneumonia.
|
28704651 |
2017 |
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
HMGB1 translocation and release mediate cigarette smoke-induced pulmonary inflammation in mice through a TLR4/MyD88-dependent signaling pathway.
|
27807045 |
2017 |
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results showed an alleviated pulmonary inflammation and fibrosis in myeloid differentiation primary response gene 88 (MyD88)-deficient mice treated with bleomycin (BLM), accompanied with a reduced TGF-β signaling and production of pro-fibrotic cytokines, including TNF-α, IL-1β.
|
28662409 |
2017 |
Pneumonia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that MyD88 expression in two distinct lung epithelial cell types does not contribute to host defense during pneumonia caused by a common human gram-negative pathogen.
|
28187270 |
2017 |
Pneumonia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Desert dust induces TLR signaling to trigger Th2-dominant lung allergic inflammation via a MyD88-dependent signaling pathway.
|
26882889 |
2016 |
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Caveolin-1 Tyr14 phosphorylation induces interaction with TLR4 in endothelial cells and mediates MyD88-dependent signaling and sepsis-induced lung inflammation.
|
24244013 |
2013 |
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conclude that MyD88-dependent signaling through multiple receptors is important in the pathogenesis of acute lung inflammation and injury following ischemia and reperfusion.
|
24146959 |
2013 |
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, we investigated the role of TRIF and MyD88 in K. pneumoniae pneumonia.
|
19846873 |
2009 |