Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 AlteredExpression disease BEFREE The apoptosis proteins and the downstream genes of NF-κB pathway were detected by Western blot.<b>Results:</b> we displayed that miR-146b was down-regulated, whereas MyD88 was up-regulated in the serum of children patients with pneumonia and in WI-38 cells treated with LPS. 31583932 2020
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 Biomarker disease BEFREE Myeloid differentiation primary response 88 (MyD88) is involved in gram positive bacteria-induced lung inflammation by Toll-like receptors (TLRs). 30802676 2019
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 Biomarker disease BEFREE The triggering receptor expressed by myeloid cells-1 activates TLR4-MyD88-NF-κB-dependent signaling to aggravate ventilation-induced lung inflammation and injury in mice. 29869715 2018
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 Biomarker disease BEFREE In order to understand how the absence of MyD88 can interfere in the laser effect on lung inflammation, MyD88<sup>-/-</sup> mice were treated or not with laser and subjected to occlusion of the superior mesenteric artery (45 min) followed by intestinal reperfusion (4 h). 27924419 2017
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 Biomarker disease BEFREE Comparing efficacies of phage-curative and prophylactic treatments in healthy immunocompetent, MyD88-deficient, lymphocyte-deficient, and neutrophil-depleted murine hosts revealed that neutrophil-phage synergy is essential for the resolution of pneumonia. 28704651 2017
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 Biomarker disease BEFREE HMGB1 translocation and release mediate cigarette smoke-induced pulmonary inflammation in mice through a TLR4/MyD88-dependent signaling pathway. 27807045 2017
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 Biomarker disease BEFREE The results showed an alleviated pulmonary inflammation and fibrosis in myeloid differentiation primary response gene 88 (MyD88)-deficient mice treated with bleomycin (BLM), accompanied with a reduced TGF-β signaling and production of pro-fibrotic cytokines, including TNF-α, IL-1β. 28662409 2017
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 AlteredExpression disease BEFREE These results indicate that MyD88 expression in two distinct lung epithelial cell types does not contribute to host defense during pneumonia caused by a common human gram-negative pathogen. 28187270 2017
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 Biomarker disease CTD_human Desert dust induces TLR signaling to trigger Th2-dominant lung allergic inflammation via a MyD88-dependent signaling pathway. 26882889 2016
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 Biomarker disease BEFREE Caveolin-1 Tyr14 phosphorylation induces interaction with TLR4 in endothelial cells and mediates MyD88-dependent signaling and sepsis-induced lung inflammation. 24244013 2013
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 Biomarker disease BEFREE We conclude that MyD88-dependent signaling through multiple receptors is important in the pathogenesis of acute lung inflammation and injury following ischemia and reperfusion. 24146959 2013
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 Biomarker disease BEFREE Therefore, we investigated the role of TRIF and MyD88 in K. pneumoniae pneumonia. 19846873 2009