NBN, nibrin, 4683

N. diseases: 291; N. variants: 194
Disease: Lymphoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.150 Biomarker group BEFREE The combined data would fit a model in which an NBN gene defect results in a higher frequency of DNA misrejoining during double-strand break (DSB) repair, thereby contributing to an increased likelihood of lymphoma formation in NBS patients. 18788073 2008
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.150 AlteredExpression group BEFREE Examination of clinical history indicated a clear and statistically significant correlation between p70-nibrin expression levels and lymphoma incidence. 16840438 2007
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.150 PosttranslationalModification group BEFREE No evidence for deletions of the NBS1 gene in lymphomas. 11343781 2001
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.150 GeneticVariation group BEFREE The present results suggested that the contribution of NBS1 mutations to B-cell ML was minimal, despite the fact that the NBS1 gene was causative factor in these cases. 10928123 2000
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.150 Biomarker group BEFREE In contrast, 8 of 9 tumors reported in NBS, which shows the same cellular features as A-T, were lymphomas and none was a leukemia. 8555463 1996
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.150 Biomarker group HPO