NBN, nibrin, 4683

N. diseases: 291; N. variants: 194
Disease: ovarian neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.140 Biomarker disease BEFREE Significant associations with OC were observed in <i>BRCA1, BRCA2, RAD51C</i> and <i>RAD51D.</i> Other homologous recombination genes, <i>BARD1, NBN,</i> and <i>PALB2,</i> were not significantly associated with OC. 31341520 2019
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.140 Biomarker disease BEFREE Next generation sequencing was used to identify germline mutations in the coding regions of four candidate susceptibility genes-BRIP1, BARD1, PALB2 and NBN-in 3236 invasive EOC case patients and 3431 control patients of European origin, and in 2000 unaffected high-risk women from a clinical screening trial of ovarian cancer (UKFOCSS). 26315354 2015
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.140 GeneticVariation disease LHGDN Ovarian cancer patient with germline mutations in both BRCA1 and NBN genes. 18940477 2008
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.140 GeneticVariation disease BEFREE Our results indicate that NBS1 mutations do not contribute significantly to breast or ovarian cancer development. 17695489 2007
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.140 GeneticVariation disease LHGDN Our results indicate that NBS1 mutations do not contribute significantly to breast or ovarian cancer development. 17695489 2007
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.140 Biomarker disease HPO
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.140 CausalMutation disease CLINVAR