NCAM1, neural cell adhesion molecule 1, 4684

N. diseases: 445; N. variants: 34
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 AlteredExpression group BEFREE Phenotypic and genotypic studies revealed that the lymphoma is originated from either NK- or γδ T-cell, both of which express CD56. 31041299 2019
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 AlteredExpression group BEFREE CD16/CD56 expression without CD38<sup>higher</sup> and the lack of CD16/CD56 with CD38<sup>higher</sup> expression proves to be a reliable, fast, and cost-effective method for diagnosing 11q aberration and MYC rearrangements in CD10(+) aggressive lymphomas, respectively. 29327714 2018
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 AlteredExpression group BEFREE Described for the first time in 1994 as CD4+ cutaneous lymphoma with high expression of CD56, BPDCN has been known previously with various names such as blastic natural killer (NK) leukemia/lymphoma, agranular CD4+ CD56+ hematodermic neoplasm, and agranular CD4+ NK cell leukemia. 29237977 2018
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 Biomarker group BEFREE The aim of this work was to study the expression of human leukocyte antigen G (HLA-G) and interleukin 10 (IL-10) in conjunction with expression of HLA-G killer-cell inhibitory receptor ligand immunoglobulin-like transcript 2 (ILT2) in CD3+, CD19+, CD56+ lymphomas, and ILT4 in CD14+ cells from patients with systemic lupus erythematosus (SLE). 22562117 2013
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 Biomarker group BEFREE The NK-92 cell line (CD56+/CD3-) that was isolated from a patient with lymphoma has predictable high cytotoxic activity and can be expanded under good manufacturing practice conditions in recombinant interleukin-2. 24094496 2013
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 Biomarker group BEFREE This nodal EBV(+) lymphoma possessed a distinctive immunophenotype of high CD8(+), CD56(-) pattern with an aggressive clinical course (median, 6.6 months). 22690710 2012
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 Biomarker group BEFREE In type II EATL, lymphoma cells of the 16 (80%) and 11 (55%) cases were positive for CD56 and CD8, respectively. 21323966 2011
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 Biomarker group BEFREE We recently reported that overexpression of miR-21 and/or miR-155 leads to activation of the phosphoinositide 3-kinase (PI3K)-AKT pathway in malignant lymphomas expressing CD3(-)CD56(+) natural killer (NK) cell antigen. 21502955 2011
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 AlteredExpression group BEFREE In the present study, we found that in NK-cell lymphoma lines (n = 10) and specimens of primary lymphoma (n = 10), levels of miR-21 and miR-155 expression were inversely related and were significantly greater than those found in normal natural killer (CD3(-)CD56(+)) cells (n = 8). 19641183 2009
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 Biomarker group BEFREE CD4+/CD56+ hematodermic neoplasm (HN), formerly known as a blastic natural killer (NK) cell lymphoma, is a rare subtype of a cutaneous dendritic cell neoplasm notable for highly aggressive behavior. 18005171 2008
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 Biomarker group BEFREE To investigate the clinicopathological features of six unusual cases of nodal CD56+ and Epstein-Barr virus (EBV)+ T/natural killer (NK)-cell lymphoma, a putative nodal counterpart of nasal NK/T-cell lymphoma (nodal T/NK-cell lymphoma of nasal type) in comparison with nasal NK/T-cell lymphoma with secondary lymph node involvement (n = 24) and peripheral T-cell lymphoma (PTCL) of cytotoxic molecule (CTM)+ and EBV+ type (n = 21). 18370955 2008
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 AlteredExpression group BEFREE Expression of CD56 is associated with a poor prognosis in subcutaneous panniculitis-like T-cell lymphoma and blastic natural killer cell lymphoma. 17052504 2006
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 Biomarker group BEFREE Fifty-one cases of cCD3+ T-cell intracellular antigen (TIA-1)+ CD56+ lymphomas of extranodal/extranasal origin were included in the study. 15139996 2004
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 Biomarker group BEFREE To describe the clinical, pathological and molecular features in six cases of CD56+ lymphoma with cutaneous presentation. 12653743 2003
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 Biomarker group BEFREE Among these six cases, four female CD56(-)/CD44(-)/CD8(-)/CD45RO(+)/CD45RA(-) cases constituted a distinct group with a better prognosis than the rest of the male cases of sinonasal lymphomas. 12533686 2003
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 AlteredExpression group BEFREE We report the clinical and laboratory findings of a patient with an aggressive Epstein-Barr virus positive CD2+/CD56+ natural killer-cell lymphoma with a high mitotic activity and complex chromosomal abnormalities presenting with life-threatening pericardial and pleural effusions, disseminated skin lesions, breast nodule and large suprarenal masses. 11911423 2002
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 Biomarker group BEFREE We report 4 cases of lymphomas/leukemias with the unusual CD56/CD4 phenotype. 11488062 2001
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 Biomarker group BEFREE Agranular CD4+CD56+ blastic natural killer leukemia/lymphoma. 11401089 2001
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 AlteredExpression group BEFREE A rare form of putative natural killer (NK) cell lymphoma called blastic NK cell lymphoma appears to be clinicopathologically distinctive in showing a homogenous lymphoblast, variable expression of CD2, CD4, CD56 and TdT, negative for surface CD3, T-cell receptor antigen, CD16, CD34 and lack of association with Epstein-Barr virus (EBV). 11328295 2001
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 Biomarker group BEFREE Coexistence of two distinct cell populations (CD56(+)TcRgammadelta(+) and CD56(+)TcRgammadelta(-)) in a case of aggressive CD56(+) lymphoma/leukemia. 10800166 2000
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 Biomarker group BEFREE Four patients with cutaneous CD4+ and CD56+ lymphoma were studied. 10828627 2000
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 Biomarker group BEFREE Thus, there seems to be a useful distinction between the classical NK/T type of nasal lymphoma (CD56+/n-cdk6+/CD44-/TcR-GR-) and PTL (CD56-/n-cdk6-/CD44+/TcR-GR+) involving the nasal region. 10879740 2000
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 Biomarker group BEFREE The indolent behavior of this tumor indicates its similarity to other primary cutaneous CD30+ large cell lymphomas and its difference from other CD56+ lymphomas involving the skin, which often exhibit an aggressive clinical course. 11048978 2000
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 Biomarker group BEFREE When immunostained using paraffin embedded tissue, 6 upper aerodigestive lymphomas were negative for CD56 in which 4 cases lacked clonal TCR gene rearrangement. 11066052 2000
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.100 AlteredExpression group BEFREE Seven retrospectively identified cases of lymphomas with co-expression of CD56 and CD30 presenting in the skin comprise this study. 10955685 2000