NCAM1, neural cell adhesion molecule 1, 4684

N. diseases: 445; N. variants: 34
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression disease BEFREE Phenotypic and genotypic studies revealed that the lymphoma is originated from either NK- or γδ T-cell, both of which express CD56. 31041299 2019
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression disease BEFREE Described for the first time in 1994 as CD4+ cutaneous lymphoma with high expression of CD56, BPDCN has been known previously with various names such as blastic natural killer (NK) leukemia/lymphoma, agranular CD4+ CD56+ hematodermic neoplasm, and agranular CD4+ NK cell leukemia. 29237977 2018
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE The NK-92 cell line (CD56+/CD3-) that was isolated from a patient with lymphoma has predictable high cytotoxic activity and can be expanded under good manufacturing practice conditions in recombinant interleukin-2. 24094496 2013
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE This nodal EBV(+) lymphoma possessed a distinctive immunophenotype of high CD8(+), CD56(-) pattern with an aggressive clinical course (median, 6.6 months). 22690710 2012
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE In type II EATL, lymphoma cells of the 16 (80%) and 11 (55%) cases were positive for CD56 and CD8, respectively. 21323966 2011
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression disease BEFREE In the present study, we found that in NK-cell lymphoma lines (n = 10) and specimens of primary lymphoma (n = 10), levels of miR-21 and miR-155 expression were inversely related and were significantly greater than those found in normal natural killer (CD3(-)CD56(+)) cells (n = 8). 19641183 2009
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE CD4+/CD56+ hematodermic neoplasm (HN), formerly known as a blastic natural killer (NK) cell lymphoma, is a rare subtype of a cutaneous dendritic cell neoplasm notable for highly aggressive behavior. 18005171 2008
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE To investigate the clinicopathological features of six unusual cases of nodal CD56+ and Epstein-Barr virus (EBV)+ T/natural killer (NK)-cell lymphoma, a putative nodal counterpart of nasal NK/T-cell lymphoma (nodal T/NK-cell lymphoma of nasal type) in comparison with nasal NK/T-cell lymphoma with secondary lymph node involvement (n = 24) and peripheral T-cell lymphoma (PTCL) of cytotoxic molecule (CTM)+ and EBV+ type (n = 21). 18370955 2008
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression disease BEFREE Expression of CD56 is associated with a poor prognosis in subcutaneous panniculitis-like T-cell lymphoma and blastic natural killer cell lymphoma. 17052504 2006
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE Extranodal CD56+ EBV- lymphoma at extranasal sites is a clinically less aggressive malignancy and displays less necrosis than CD56+ EBV+ lymphoma. 15139996 2004
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE To describe the clinical, pathological and molecular features in six cases of CD56+ lymphoma with cutaneous presentation. 12653743 2003
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression disease BEFREE We report the clinical and laboratory findings of a patient with an aggressive Epstein-Barr virus positive CD2+/CD56+ natural killer-cell lymphoma with a high mitotic activity and complex chromosomal abnormalities presenting with life-threatening pericardial and pleural effusions, disseminated skin lesions, breast nodule and large suprarenal masses. 11911423 2002
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE Agranular CD4+CD56+ blastic natural killer leukemia/lymphoma. 11401089 2001
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression disease BEFREE A rare form of putative natural killer (NK) cell lymphoma called blastic NK cell lymphoma appears to be clinicopathologically distinctive in showing a homogenous lymphoblast, variable expression of CD2, CD4, CD56 and TdT, negative for surface CD3, T-cell receptor antigen, CD16, CD34 and lack of association with Epstein-Barr virus (EBV). 11328295 2001
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE Thus, there seems to be a useful distinction between the classical NK/T type of nasal lymphoma (CD56+/n-cdk6+/CD44-/TcR-GR-) and PTL (CD56-/n-cdk6-/CD44+/TcR-GR+) involving the nasal region. 10879740 2000
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE Four patients with cutaneous CD4+ and CD56+ lymphoma were studied. 10828627 2000
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE Coexistence of two distinct cell populations (CD56(+)TcRgammadelta(+) and CD56(+)TcRgammadelta(-)) in a case of aggressive CD56(+) lymphoma/leukemia. 10800166 2000
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE We consider that blastoid NK cell lymphoma is an extremely aggressive subtype of CD56-positive lymphomas, and high-dose chemotherapy with peripheral blood stem cell rescue should be included for the choice of the treatment. 10048432 1999
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE Primary CD56 + nasal-type T/natural killer-cell subcutaneous panniculitic lymphoma: presentation as haemophagocytic syndrome. 10583121 1999
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE The diagnosis of NK cell lymphoma was made on the basis of morphological and immunological characteristics (CD3-CD56+) found on skin biopsy of one of multiple skin nodules which subsequently developed in association with splenomegaly, thrombocytopenia and continuing neutropenia. 9869207 1998
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression disease BEFREE Fifty percent of MVLs express CD56, suggesting a role for adhesion molecules in the distribution of this lymphoma. 9521469 1998
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE In this study we analysed the cytogenetic findings of seven patients with CD56-positive putative NK cell lymphoma/leukaemia. 9326190 1997
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE Five CD3- CD56+ lymphoma patients presenting with nodular lesions were identified among 180 immunophenotyped cutaneous lymphomas. 9470917 1997
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 AlteredExpression disease BEFREE CD56/neural cell adhesion molecule expression in primary extranodal Ki-1/CD30+ lymphoma. Report of a pediatric case with simultaneous cutaneous and bone localizations. 9261474 1997
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.100 Biomarker disease BEFREE This case demonstrated nasal cavity and cutaneous tumor infiltrates consistent with previously described CD3-negative, CD56-positive NK-cell lymphoma of the upper aerodigestive tract. 7530849 1994