|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.
|
31374203 |
2019 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
These findings suggest dysregulation of ER-associated GPI-AP protein processing, with impacts on post-translational modifications of proteins previously implicated in schizophrenia such as NCAM and GPC1.
|
30664618 |
2019 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our study supports that IL-1ra and NCAM-1/CD56 may be considered as markers of developing SZ.
|
29898582 |
2018 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
PSYGENET |
Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice.
|
24057454 |
2015 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
PSYGENET |
We conducted a two-stage association analysis on 17 NCAM1 SNPs in two independent Han Chinese schizophrenia case-control cohorts (discovery sample from Hunan Province: 986 patients and 1040 normal controls; replication sample from Yunnan Province: 564 cases and 547 healthy controls).
|
25445624 |
2014 |
|
Schizophrenia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In addition, altered PSA-NCAM expression in brains of patients with schizophrenia or bipolar disorder indicates a functional dysregulation of glycosylation in mental illness.
|
24651862 |
2014 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
We conducted a two-stage association analysis on 17 NCAM1 SNPs in two independent Han Chinese schizophrenia case-control cohorts (discovery sample from Hunan Province: 986 patients and 1040 normal controls; replication sample from Yunnan Province: 564 cases and 547 healthy controls).
|
25445624 |
2014 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
PSYGENET |
Alterations in NCAM expression or proteolytic cleavage have been linked to human neuropsychiatric disorders such as schizophrenia, bipolar disorder and Alzheimer's disease, and may contribute to cognitive dysfunction.
|
21515372 |
2011 |
|
Schizophrenia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
This data suggests NCAM-180 mRNA expression is altered in a regionally-specific manner in schizophrenia and these changes are associated with the early period following diagnosis.
|
19411161 |
2009 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that the five SNPs within NCAM1 gene we studied may not play a major role in the schizophrenia susceptibility in the Chinese Han population.
|
18601968 |
2008 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Both SNPs and splice variants in the NCAM1 gene were analysed in bipolar disorder and schizophrenia.
|
17413444 |
2007 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Both SNPs and splice variants in the NCAM1 gene were analysed in bipolar disorder and schizophrenia.
|
17413444 |
2007 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Neural cell adhesion molecule 1 (NCAM1, aliases NCAM and CD56) may be a candidate gene for schizophrenia or for neurocognition in schizophrenia as supported by linkage and functional findings.
|
17161382 |
2007 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
LHGDN |
Characterization of human cleaved N-CAM and association with schizophrenia.
|
11681838 |
2001 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that structural alterations in the NCAM gene are unlikely to play a major role in schizophrenia, although a function for the NCAM molecule in the etiology of the disease remains an intriguing hypothesis.
|
9154219 |
1997 |
|
Mood Disorders
|
0.420 |
GeneticVariation
|
group |
GWASCAT |
Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.
|
29942085 |
2018 |
|
Mood Disorders
|
0.420 |
Biomarker
|
group |
PSYGENET |
In this review, we present evidence that implicates alterations in the levels of the neural cell adhesion molecules of the immunoglobulin superfamily, NCAM and L1, among the mechanisms contributing to stress-related mood disorders and, potentially, in antidepressant action.
|
17409734 |
2007 |
|
Mood Disorders
|
0.420 |
Biomarker
|
group |
BEFREE |
In this review, we present evidence that implicates alterations in the levels of the neural cell adhesion molecules of the immunoglobulin superfamily, NCAM and L1, among the mechanisms contributing to stress-related mood disorders and, potentially, in antidepressant action.
|
17409734 |
2007 |
|
Mood Disorders
|
0.420 |
GeneticVariation
|
group |
LHGDN |
We therefore undertook genetic analysis of NCAM1 in mood disorders.
|
15050861 |
2004 |
|
Mood Disorders
|
0.420 |
Biomarker
|
group |
BEFREE |
We therefore undertook genetic analysis of NCAM1 in mood disorders.
|
15050861 |
2004 |
|
Mood Disorders
|
0.420 |
Biomarker
|
group |
PSYGENET |
We therefore undertook genetic analysis of NCAM1 in mood disorders.
|
15050861 |
2004 |
|
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.
|
29942085 |
2018 |
|
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
As a result, 99 genes were listed as the differentially expressed genes in major depression, of which several genes such as FGFR1, NCAM1, and CAMK2A were of interest.
|
18068248 |
2008 |
|
Miscarriage
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
The intensity of CD56 expression was reduced in the presence of trophoblast cells and IL-2 in non-pregnant women with recurrent miscarriage in the secretory versus the proliferative phase of the menstrual cycle.
|
31317282 |
2019 |
|
Miscarriage
|
0.340 |
Biomarker
|
disease |
BEFREE |
Differential angiogenic cytokine profile of isolated CD56+ uNK cells suggested the role of uNK cells in the altered endometrial vascularity at the time of implantation, which may account for the endometrial contribution to recurrent miscarriage.
|
29396049 |
2018 |