NCL, nucleolin, 4691
N. diseases: 167; N. variants: 4
Source: ALL
| Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
|---|---|---|---|---|---|---|---|
|
|
0.060 | Biomarker | disease | BEFREE | Although the purified virus stocks were equally susceptible to nucleolin-receptor blocking by the DNA aptamer AS1411, the FPLC-purified RSV was significantly less susceptible to anti-RSV polyclonal antibody neutralization; there was 69% inhibition (<i>p</i> = 0.02) of the sucrose ultracentrifugation-purified RSV, 38% inhibition (<i>p</i> = 0.03) of the unpurified RSV, but statistically ineffective neutralization in the FPLC-purified RSV (22% inhibition; <i>p</i> = 0.30). | 28771197 | 2017 |
|
|
0.060 | Biomarker | disease | BEFREE | The potential interaction of RSV F protein with TLR4 and nucleolin was examined by coimmunoprecipitation. | 29427996 | 2018 |
|
|
0.060 | Biomarker | disease | BEFREE | The results indicated that TLR4 and C23 gene knockdown decreased the amount of F protein in RSV-infected N2a cells, inhibited RSV propagation, attenuated N2a neuronal injury, diminished cell apoptosis levels, downregulated TLR3 and TLR7 protein expression, and reduced inflammatory protein expression. | 31081244 | 2019 |
|
|
0.060 | Biomarker | disease | BEFREE | We discuss the possible role of PDI and nucleolin in NDV and RSV entry, respectively. | 25109545 | 2014 |
|
|
0.060 | Biomarker | disease | BEFREE | We studied the effects of re-purposing AS1411, an anti-cancer compound that binds cell surface NCL, as a possible novel strategy for RSV therapy in vitro and in vivo. | 28925950 | 2017 |
|
|
0.060 | Biomarker | disease | BEFREE | With our recent discovery of nucleolin as a functional fusion receptor for RSV, comes the possibility of a number of new approaches to the development of novel strategies for RSV prophylaxis and therapy, as well as raising some new questions concerning the pathobiology of RSV infection and tropism. | 23518574 | 2013 |