Lymphoma
|
0.900 |
AlteredExpression
|
group |
BEFREE |
ATM activity in T cells is critical for immune surveillance of lymphoma in vivo.
|
31690822 |
2020 |
Lymphoma
|
0.900 |
Biomarker
|
group |
RGD |
Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage.
|
27895165 |
2017 |
Lymphoma
|
0.900 |
Biomarker
|
group |
RGD |
A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype.
|
28007901 |
2017 |
Lymphoma
|
0.900 |
Biomarker
|
group |
GENOMICS_ENGLAND |
Germline Genetic Predisposition to Hematologic Malignancy.
|
28297620 |
2017 |
Lymphoma
|
0.900 |
Biomarker
|
group |
BEFREE |
Although EμCyclinD1 is not sufficient to induce lymphomas, EμCyclinD1 accelerates the kinetics and increases the incidence of clonal lymphomas in ATM-deficient B-cells and skews the lymphomas toward pre-GC-derived small lymphocytic neoplasms, sharing morphological features of human MCL.
|
25676421 |
2015 |
Lymphoma
|
0.900 |
Biomarker
|
group |
BEFREE |
In humans, ATM deficiency predisposes to B- and T-cell lymphomas, but in mice it leads only to thymic lymphomas.
|
24913718 |
2014 |
Lymphoma
|
0.900 |
Biomarker
|
group |
BEFREE |
Finally, we demonstrate that DNA-PKcs inhibitors are effective as single agents against ATM-defective lymphomas in vivo.
|
23761041 |
2013 |
Lymphoma
|
0.900 |
Biomarker
|
group |
BEFREE |
Overall, these data identify a novel molecular mechanism through which ATM kinase may regulate the immune system homeostasis and impair lymphoma development.
|
17932249 |
2008 |
Lymphoma
|
0.900 |
Biomarker
|
group |
BEFREE |
We hypothesize that ATM function is slightly attenuated by some variants, which could reduce double-stranded break repair capacity, contributing to the occurrence of translocations and subsequent lymphomas.
|
17640065 |
2007 |
Lymphoma
|
0.900 |
GeneticVariation
|
group |
BEFREE |
The mutations in the ATM gene may be involved in the development of some subtypes of sporadic lymphomas and leukemias.
|
17516749 |
2007 |
Lymphoma
|
0.900 |
AlteredExpression
|
group |
BEFREE |
The methylation status of the ATM promoter CpG island was determined in 25 samples; ATM protein expression was assessed by Western blot in 9 lymphomas.
|
16631465 |
2006 |
Lymphoma
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Inherited biallelic mutations of the ATM (ataxia-telangiectasia mutated) gene cause ataxia-telangiectasia, a rare autosomal recessive disorder associated with a high incidence of childhood leukaemias and lymphomas, suggesting that ATM gene alterations may be involved in lymphomagenesis.
|
14628072 |
2004 |
Lymphoma
|
0.900 |
GeneticVariation
|
group |
BEFREE |
ATM mutations have been reported in adult sporadic lymphoma and leukaemia.
|
14735203 |
2004 |
Lymphoma
|
0.900 |
GeneticVariation
|
group |
BEFREE |
However, surveys of the ATM mutation status in lymphoma have been limited due to the large size (62 exons) and complex mutational spectrum of this gene.
|
12697903 |
2003 |
Lymphoma
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Germ-line mutations in the ATM gene cause ataxia-telangiectasia (A-T), a multisystem disorder associated with predisposition to lymphoma and acute leukemia.
|
12149228 |
2002 |
Lymphoma
|
0.900 |
Biomarker
|
group |
BEFREE |
The recurrent 11q22-23 deletions found in mantle cell lymphoma (MCL) suggest that ATM could be inactivated in these lymphomas.
|
11756177 |
2002 |
Lymphoma
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Mutation of the ATM gene is not involved in the pathogenesis of either follicle center lymphoma or its transformation to higher-grade lymphoma.
|
12148890 |
2002 |
Lymphoma
|
0.900 |
AlteredExpression
|
group |
BEFREE |
The association between mutation of the ATM gene and a high incidence of lymphoid malignancy in patients with AT, together with the development of lymphoma in Atm deficient mice, supports the proposal that inactivation of the ATM gene may be of importance in the pathogenesis of sporadic lymphoid malignancy.
|
11429421 |
2001 |
Lymphoma
|
0.900 |
GeneticVariation
|
group |
BEFREE |
A hemizygous ATM deletion was seen in 44% to 88% of the interphase cells in 15 cases (11.1%); four patients had an indolent lymphoma (follicular center cell lymphoma), and 11 patients had an aggressive lymphoma (five mantle-cell lymphomas [MCLs] and six diffuse large-cell lymphomas).
|
10893293 |
2000 |
Lymphoma
|
0.900 |
GeneticVariation
|
group |
BEFREE |
We have found previously an overrepresentation (3.4%) of ATM mutations in a subset of 88 selected breast cancer patients with a family history of breast cancer, leukemia, and lymphoma.
|
9537233 |
1998 |
Lymphoma
|
0.900 |
Biomarker
|
group |
BEFREE |
While ATM plays a major role in signaling the p53 response to DNA strand break damage, Atm-/- p53(-/-) mice develop lymphomas earlier than Atm-/- or p53(-/-) mice, indicating that mutations in these two genes lead to synergy in tumorigenesis.
|
9632822 |
1998 |
Lymphoma
|
0.900 |
GeneticVariation
|
group |
BEFREE |
The ATM gene deficient in ataxia-telangiectasia, a recessive multisystem disease associated with a high risk of lymphomas and leukemias, was found previously to be inactivated in a rare sporadic malignancy, T-cell prolymphocytic leukemia (T-PLL), which is often associated with cytogenetic aberrations of chromosome 14.
|
9622061 |
1998 |
Lymphoma
|
0.900 |
GenomicAlterations
|
group |
CGI |
|
|
|
Lymphoma
|
0.900 |
CausalMutation
|
group |
CGI |
|
|
|
Lymphoma
|
0.900 |
Biomarker
|
group |
HPO |
|
|
|