Malignant neoplasm of stomach
|
0.600 |
Biomarker
|
disease |
BEFREE |
PD-L1 membrane expression on tumour cells (TC) and infiltrating immune cells (IC), CD3 + T-lymphocytes, CD8+ cytotoxic T-cells, ATM and HER2 were assessed by immunohistochemistry (IHC) in the ACRG (Asian Cancer Research Group) GC cohort (N = 380).
|
30729066 |
2019 |
Malignant neoplasm of stomach
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, CENPO knockdown decreased ataxia telangiectasia mutated (ATM), cyclin D1 and c‑Jun expression, indicating that the ATM signaling pathway may be involved in CENPO‑mediated regulation of GC cell growth.
|
31485675 |
2019 |
Malignant neoplasm of stomach
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
HOXC10 promoted GC cell invasion and migration, regulated the expression of activated ATM and markers of NF-κB signaling.
|
29753747 |
2018 |
Malignant neoplasm of stomach
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The clinical significance of PD-L1 in advanced gastric cancer is dependent on <i>ARID1A</i> mutations and ATM expression.
|
30221053 |
2018 |
Malignant neoplasm of stomach
|
0.600 |
Biomarker
|
disease |
BEFREE |
ATM was downregulated in GC patients in Xinjiang, especially for Uygurs and Kazaks, which suggested ATM to be an independent indicator of prognosis for GC therapy.
|
28647209 |
2017 |
Malignant neoplasm of stomach
|
0.600 |
Biomarker
|
disease |
BEFREE |
Further clinical studies on the interaction between AZD 6738 and ATM deficiency are warranted to develop novel treatment strategies for gastric cancer.<i></i>.
|
28138034 |
2017 |
Malignant neoplasm of stomach
|
0.600 |
Biomarker
|
disease |
BEFREE |
Although ATM was shown to be associated with poor prognosis in gastric cancer, its implications as a predictive biomarker for cancer chemotherapy remain unexplored.
|
27638859 |
2016 |
Malignant neoplasm of stomach
|
0.600 |
Biomarker
|
disease |
BEFREE |
Gemcitabine was found to be a lytic inducer via activation of the ataxia telangiectasia-mutated (ATM)/p53 genotoxic stress pathway in EBVaGC.
|
26427042 |
2015 |
Malignant neoplasm of stomach
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Loss-of-function variants in ATM confer risk of gastric cancer.
|
26098866 |
2015 |
Malignant neoplasm of stomach
|
0.600 |
Biomarker
|
disease |
CTD_human |
We found a new gastric cancer association with loss-of-function mutations in ATM (gene test, P = 8.0 × 10(-12); odds ratio (OR) = 4.74).
|
26098866 |
2015 |
Malignant neoplasm of stomach
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition, data revealed hsa-let-7 g miRNA increased the sensitivity of GC to X-rays involving in ATM regulation as well according to application of X-rays (another DDR inducer).
|
25972194 |
2015 |
Malignant neoplasm of stomach
|
0.600 |
Biomarker
|
disease |
BEFREE |
Intra-Tumoral Heterogeneity of HER2, FGFR2, cMET and ATM in Gastric Cancer: Optimizing Personalized Healthcare through Innovative Pathological and Statistical Analysis.
|
26587992 |
2015 |
Malignant neoplasm of stomach
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Further evaluation of ATM mutations in hereditary gastric cancer will facilitate genetic testing and risk assessment.
|
26506520 |
2015 |
Malignant neoplasm of stomach
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
There was inverse correlation between miR-181a and ATM protein expression in gastric cancer and normal gastric tissues.
|
24531888 |
2014 |
Malignant neoplasm of stomach
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines.
|
24841718 |
2014 |
Malignant neoplasm of stomach
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Ataxia-telangiectasia-mutated protein expression with microsatellite instability in gastric cancer as prognostic marker.
|
23649938 |
2014 |
Malignant neoplasm of stomach
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Two human GC cell lines (SNU-1 and -638) showed ATM intron mutations, deletion in RT-PCR and direct sequencing, and ATM protein loss by IHC.
|
24324828 |
2013 |
Malignant neoplasm of stomach
|
0.600 |
Biomarker
|
disease |
BEFREE |
Expression loss of breast cancer type 1 susceptibility protein (BRCA1), ataxia telangiectasia mutated (ATM), ATM-Rad3-related (ATR), mediator of DNA damage checkpoint protein 1 (MDC1) and meiotic recombination 11 (Mre11) were correlated with their clinicopathological parameters in gastric cancer (GC).
|
23569343 |
2013 |
Malignant neoplasm of stomach
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cytotoxicity of 5-Aza-2'-deoxycytidine against gastric cancer involves DNA damage in an ATM-P53 dependent signaling pathway and demethylation of P16(INK4A).
|
23201008 |
2013 |
Malignant neoplasm of stomach
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that ATM mutations might be a pathogenic factor for an increased risk of gastric cancer, and the dysfunction of ATM may lead to a hypersensitivity to ionizing radiation in gastric cancer cells, possibly by a p53-dependent pathway.
|
14706517 |
2004 |
Malignant neoplasm of stomach
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No evidence for constitutional ATM mutation in breast/gastric cancer families.
|
9592204 |
1998 |
Malignant neoplasm of stomach
|
0.600 |
GenomicAlterations
|
disease |
CGI |
|
|
|
Malignant neoplasm of stomach
|
0.600 |
CausalMutation
|
disease |
CGI |
|
|
|