|
Psychotic Disorders
|
0.310 |
Biomarker
|
group |
PSYGENET |
By screening a cDNA library from human umbilical artery endothelial cells with serum from an SLE patient with psychosis, we identified one positive strongly reactive clone encoding the C-terminal region (C-ter) of Nedd5, an intracytoplasmatic protein of the septin family.
|
15987492 |
2005 |
|
Psychotic Disorders
|
0.310 |
GeneticVariation
|
group |
BEFREE |
By screening a cDNA library from human umbilical artery endothelial cells with serum from an SLE patient with psychosis, we identified one positive strongly reactive clone encoding the C-terminal region (C-ter) of Nedd5, an intracytoplasmatic protein of the septin family.
|
15987492 |
2005 |
|
Nonorganic psychosis
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
By screening a cDNA library from human umbilical artery endothelial cells with serum from an SLE patient with psychosis, we identified one positive strongly reactive clone encoding the C-terminal region (C-ter) of Nedd5, an intracytoplasmatic protein of the septin family.
|
15987492 |
2005 |
|
Nonorganic psychosis
|
0.310 |
Biomarker
|
disease |
PSYGENET |
By screening a cDNA library from human umbilical artery endothelial cells with serum from an SLE patient with psychosis, we identified one positive strongly reactive clone encoding the C-terminal region (C-ter) of Nedd5, an intracytoplasmatic protein of the septin family.
|
15987492 |
2005 |
|
Methylmalonic acidemia
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Quantitative analysis of mitochondrial protein expression in methylmalonic acidemia by two-dimensional difference gel electrophoresis.
|
16823967 |
2006 |
|
Methylmalonic aciduria
|
0.300 |
Biomarker
|
disease |
CTD_human |
Quantitative analysis of mitochondrial protein expression in methylmalonic acidemia by two-dimensional difference gel electrophoresis.
|
16823967 |
2006 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
|
20881960 |
2010 |
|
Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
|
20881960 |
2010 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Septin 2 (SEPT2) is a tumor-related gene belonging to the SEPT family that affects the cellular processes of hepatoma carcinoma cells, glioblastoma cells and mesangial cells and is highly expressed in breast cancer, biliary tract cancer and acute myeloid leukemia.
|
31402940 |
2019 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Repression of Septin9 and Septin2 suppresses tumor growth of human glioblastoma cells.
|
29724999 |
2018 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Xenografts formation assay also showed that SEPT2 overexpression significantly facilitated the growth of tumor in vivo.
|
27155525 |
2016 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
We have recently shown a significant down-regulation of both SEPT2 and MLL in myeloid neoplasias with the MLL-SEPT2 fusion gene.
|
19748670 |
2010 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
We found a significant down-regulation of both SEPT2 and MLL in MLL-SEPT2 myeloid neoplasias.
|
19445675 |
2009 |
|
Leukemia, Myelocytic, Acute
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Septin 2 (SEPT2) is a tumor-related gene belonging to the SEPT family that affects the cellular processes of hepatoma carcinoma cells, glioblastoma cells and mesangial cells and is highly expressed in breast cancer, biliary tract cancer and acute myeloid leukemia.
|
31402940 |
2019 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
HCC with high expression of both CDK2 and SEPT2 are more likely to relapse.
|
30444001 |
2019 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, the effects of SEPT2 on the above factors could be suppressed by PPARγ overexpression, suggesting that PPARγ could inhibit HCC cell growth via regulating the expression and blocking the oncogenic function of SEPT2.
|
25592041 |
2015 |
|
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The phosphorylation of SEPT2 on Ser218 by casein kinase 2 is important to hepatoma carcinoma cell proliferation.
|
19165576 |
2009 |
|
Leukemia, Myelocytic, Acute
|
0.030 |
Biomarker
|
disease |
BEFREE |
SEPT2 is the fifth septin family gene fused with MLL, making this gene family the most frequently involved in MLL-related AML (about 10% of all known fusion partners).
|
16682951 |
2006 |
|
Leukemia, Myelocytic, Acute
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The AF17q25 protein is homologous to septin family proteins, including H5, NEDD5, CDC10, and hCDCrel, which is one of the fusion partners of MLL in t(11;22)(q23;q11)-AML.
|
10485469 |
1999 |
|
Malignant neoplasm of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Septin 2 (SEPT2) is a tumor-related gene belonging to the SEPT family that affects the cellular processes of hepatoma carcinoma cells, glioblastoma cells and mesangial cells and is highly expressed in breast cancer, biliary tract cancer and acute myeloid leukemia.
|
31402940 |
2019 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Further validation of target proteins indicated that septin-2 plays a predominant role in post-transcriptional and translational modifications as well as cellular metabolism, and suggested the potential novel role of septin-2 in promoting EOC tumorigenesis through these mechanisms.
|
31105878 |
2019 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Septin 2 (SEPT2) is a tumor-related gene belonging to the SEPT family that affects the cellular processes of hepatoma carcinoma cells, glioblastoma cells and mesangial cells and is highly expressed in breast cancer, biliary tract cancer and acute myeloid leukemia.
|
31402940 |
2019 |
|
Biliary Tract Cancer
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Septin 2 (SEPT2) is a tumor-related gene belonging to the SEPT family that affects the cellular processes of hepatoma carcinoma cells, glioblastoma cells and mesangial cells and is highly expressed in breast cancer, biliary tract cancer and acute myeloid leukemia.
|
31402940 |
2019 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
The requirement of SEPT2 and SEPT7 for migration and invasion in human breast cancer via MEK/ERK activation.
|
27557506 |
2016 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Taken together, these results strongly suggest that SEPT2 and SEPT7 are involved in breast carcinogenesis and may serve as valuable therapeutic targets for breast cancer.
|
27557506 |
2016 |