Craniosynostosis
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
Upregulation of Nell-1 has been associated with craniosynostosis (CS) in humans, and validated in a mouse transgenic Nell-1 overexpression model.
|
31582804 |
2020 |
Craniosynostosis
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
The loss of the Nell1 function leads to skeletal defects in the cranial vault and vertebral column, and overexpression of Nell1 causes craniosynostosis in mice.
|
27662520 |
2017 |
Craniosynostosis
|
0.560 |
Biomarker
|
disease |
BEFREE |
We investigated the therapeutic effects of a craniosynostosis-associated molecule, NEL-like molecule-1 (NELL1; NEL [a protein strongly expressed in neural tissue encoding the epidermal growth factor-like domain]), on osteolysis induced by polyethylene (PE)-particle debris.
|
22404332 |
2012 |
Craniosynostosis
|
0.560 |
Biomarker
|
disease |
BEFREE |
The role of NELL-1, a growth factor associated with craniosynostosis, in promoting bone regeneration.
|
20647499 |
2010 |
Craniosynostosis
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
We previously reported the upregulation of NELL-1 in human craniosynostosis and the overexpression of Nell-1 in transgenic animals that induced premature suture closure associated with increased osteoblast differentiation.
|
17042739 |
2007 |
Craniosynostosis
|
0.560 |
Biomarker
|
disease |
CTD_human |
Nell-1 overexpression induced calvarial overgrowth and resulted in premature suture closure in a rodent model.
|
14672347 |
2003 |
Craniosynostosis
|
0.560 |
Biomarker
|
disease |
RGD |
In summary, Nell-1 overexpression induced calvarial overgrowth resulting in premature suture closure in a rodent model.
|
12235118 |
2002 |
Craniosynostosis
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
In summary, Nell-1 overexpression induced calvarial overgrowth resulting in premature suture closure in a rodent model.
|
12235118 |
2002 |
Craniosynostosis
|
0.560 |
AlteredExpression
|
disease |
LHGDN |
In summary, Nell-1 overexpression induced calvarial overgrowth resulting in premature suture closure in a rodent model.
|
12235118 |
2002 |
Synostotic Anterior Plagiocephaly
|
0.320 |
Biomarker
|
disease |
BEFREE |
NELL-1 is a secreted protein that was originally found to be upregulated in pathologically fusing and fused sutures in non-syndromic unilateral coronal synostosis patients.
|
29388706 |
2018 |
Synostotic Anterior Plagiocephaly
|
0.320 |
Biomarker
|
disease |
CTD_human |
Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development.
|
14672347 |
2003 |
Synostotic Anterior Plagiocephaly
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Human NELL-1 expressed in unilateral coronal synostosis.
|
9893069 |
1999 |
Major Depressive Disorder
|
0.310 |
Biomarker
|
disease |
BEFREE |
Therefore, this postmortem study identifies GC1, GRINA, and NRP-1 as novel factors associated with MDD; however, future studies will be needed to address the significance of these genes in the pathophysiology of depression and antidepressant activity.
|
23261523 |
2013 |
Major Depressive Disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Therefore, this postmortem study identifies GC1, GRINA, and NRP-1 as novel factors associated with MDD; however, future studies will be needed to address the significance of these genes in the pathophysiology of depression and antidepressant activity.
|
23261523 |
2013 |
Adenocarcinoma Of Esophagus
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
The nel-like1 (NELL1) gene maps to chromosome 11p15, which frequently undergoes loss of heterozygosity in esophageal adenocarcinoma (EAC).
|
17452981 |
2007 |
Adenocarcinoma Of Esophagus
|
0.310 |
Biomarker
|
disease |
CTD_human |
The nel-like1 (NELL1) gene maps to chromosome 11p15, which frequently undergoes loss of heterozygosity in esophageal adenocarcinoma (EAC).
|
17452981 |
2007 |
Scaphycephaly
|
0.310 |
Biomarker
|
disease |
BEFREE |
In the current study, cultured calvarial explants isolated from Nell-1 transgenic newborn mice (with mild sagittal synostosis) demonstrated continuous bone growth and overlapping sagittal sutures.
|
16936265 |
2006 |
Scaphycephaly
|
0.310 |
Biomarker
|
disease |
CTD_human |
Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development.
|
14672347 |
2003 |
Unipolar Depression
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Gene expression analysis of novel genes in the prefrontal cortex of major depressive disorder subjects.
|
23261523 |
2013 |
Acrocephaly
|
0.300 |
Biomarker
|
disease |
CTD_human |
Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development.
|
14672347 |
2003 |
Brachycephaly
|
0.300 |
Biomarker
|
disease |
CTD_human |
Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development.
|
14672347 |
2003 |
Trigonocephaly
|
0.300 |
Biomarker
|
disease |
CTD_human |
Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development.
|
14672347 |
2003 |
Synostotic Posterior Plagiocephaly
|
0.300 |
Biomarker
|
disease |
CTD_human |
Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development.
|
14672347 |
2003 |
Metopic synostosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development.
|
14672347 |
2003 |
Craniosynostosis, Type 1
|
0.300 |
Biomarker
|
disease |
CTD_human |
Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development.
|
14672347 |
2003 |