NELL1, neural EGFL like 1, 4745

N. diseases: 122; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010278
Disease: Craniosynostosis
Craniosynostosis
0.560 AlteredExpression disease BEFREE Upregulation of Nell-1 has been associated with craniosynostosis (CS) in humans, and validated in a mouse transgenic Nell-1 overexpression model. 31582804 2020
CUI: C0010278
Disease: Craniosynostosis
Craniosynostosis
0.560 AlteredExpression disease BEFREE The loss of the Nell1 function leads to skeletal defects in the cranial vault and vertebral column, and overexpression of Nell1 causes craniosynostosis in mice. 27662520 2017
CUI: C0010278
Disease: Craniosynostosis
Craniosynostosis
0.560 Biomarker disease BEFREE We investigated the therapeutic effects of a craniosynostosis-associated molecule, NEL-like molecule-1 (NELL1; NEL [a protein strongly expressed in neural tissue encoding the epidermal growth factor-like domain]), on osteolysis induced by polyethylene (PE)-particle debris. 22404332 2012
CUI: C0010278
Disease: Craniosynostosis
Craniosynostosis
0.560 Biomarker disease BEFREE The role of NELL-1, a growth factor associated with craniosynostosis, in promoting bone regeneration. 20647499 2010
CUI: C0010278
Disease: Craniosynostosis
Craniosynostosis
0.560 AlteredExpression disease BEFREE We previously reported the upregulation of NELL-1 in human craniosynostosis and the overexpression of Nell-1 in transgenic animals that induced premature suture closure associated with increased osteoblast differentiation. 17042739 2007
CUI: C0010278
Disease: Craniosynostosis
Craniosynostosis
0.560 Biomarker disease CTD_human Nell-1 overexpression induced calvarial overgrowth and resulted in premature suture closure in a rodent model. 14672347 2003
CUI: C0010278
Disease: Craniosynostosis
Craniosynostosis
0.560 Biomarker disease RGD In summary, Nell-1 overexpression induced calvarial overgrowth resulting in premature suture closure in a rodent model. 12235118 2002
CUI: C0010278
Disease: Craniosynostosis
Craniosynostosis
0.560 AlteredExpression disease BEFREE In summary, Nell-1 overexpression induced calvarial overgrowth resulting in premature suture closure in a rodent model. 12235118 2002
CUI: C0010278
Disease: Craniosynostosis
Craniosynostosis
0.560 AlteredExpression disease LHGDN In summary, Nell-1 overexpression induced calvarial overgrowth resulting in premature suture closure in a rodent model. 12235118 2002
CUI: C2931150
Disease: Synostotic Anterior Plagiocephaly
Synostotic Anterior Plagiocephaly
0.320 Biomarker disease BEFREE NELL-1 is a secreted protein that was originally found to be upregulated in pathologically fusing and fused sutures in non-syndromic unilateral coronal synostosis patients. 29388706 2018
CUI: C2931150
Disease: Synostotic Anterior Plagiocephaly
Synostotic Anterior Plagiocephaly
0.320 Biomarker disease CTD_human Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development. 14672347 2003
CUI: C2931150
Disease: Synostotic Anterior Plagiocephaly
Synostotic Anterior Plagiocephaly
0.320 AlteredExpression disease BEFREE Human NELL-1 expressed in unilateral coronal synostosis. 9893069 1999
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.310 Biomarker disease BEFREE Therefore, this postmortem study identifies GC1, GRINA, and NRP-1 as novel factors associated with MDD; however, future studies will be needed to address the significance of these genes in the pathophysiology of depression and antidepressant activity. 23261523 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.310 Biomarker disease PSYGENET Therefore, this postmortem study identifies GC1, GRINA, and NRP-1 as novel factors associated with MDD; however, future studies will be needed to address the significance of these genes in the pathophysiology of depression and antidepressant activity. 23261523 2013
CUI: C0279628
Disease: Adenocarcinoma Of Esophagus
Adenocarcinoma Of Esophagus
0.310 GeneticVariation disease BEFREE The nel-like1 (NELL1) gene maps to chromosome 11p15, which frequently undergoes loss of heterozygosity in esophageal adenocarcinoma (EAC). 17452981 2007
CUI: C0279628
Disease: Adenocarcinoma Of Esophagus
Adenocarcinoma Of Esophagus
0.310 Biomarker disease CTD_human The nel-like1 (NELL1) gene maps to chromosome 11p15, which frequently undergoes loss of heterozygosity in esophageal adenocarcinoma (EAC). 17452981 2007
CUI: C0265534
Disease: Scaphycephaly
Scaphycephaly
0.310 Biomarker disease BEFREE In the current study, cultured calvarial explants isolated from Nell-1 transgenic newborn mice (with mild sagittal synostosis) demonstrated continuous bone growth and overlapping sagittal sutures. 16936265 2006
CUI: C0265534
Disease: Scaphycephaly
Scaphycephaly
0.310 Biomarker disease CTD_human Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development. 14672347 2003
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.300 Biomarker disease PSYGENET Gene expression analysis of novel genes in the prefrontal cortex of major depressive disorder subjects. 23261523 2013
CUI: C0030044
Disease: Acrocephaly
Acrocephaly
0.300 Biomarker disease CTD_human Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development. 14672347 2003
CUI: C0221356
Disease: Brachycephaly
Brachycephaly
0.300 Biomarker disease CTD_human Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development. 14672347 2003
CUI: C0265535
Disease: Trigonocephaly
Trigonocephaly
0.300 Biomarker disease CTD_human Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development. 14672347 2003
CUI: C1833340
Disease: Synostotic Posterior Plagiocephaly
Synostotic Posterior Plagiocephaly
0.300 Biomarker disease CTD_human Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development. 14672347 2003
CUI: C1860819
Disease: Metopic synostosis
Metopic synostosis
0.300 Biomarker disease CTD_human Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development. 14672347 2003
CUI: C4551902
Disease: Craniosynostosis, Type 1
Craniosynostosis, Type 1
0.300 Biomarker disease CTD_human Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development. 14672347 2003