NEFL, neurofilament light, 4747

N. diseases: 247; N. variants: 26
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.210 Biomarker disease BEFREE Models examine the relationship of bodily pain, injury as a reason for retirement or not re-signing with a team, length of NFL career, sociodemographic characteristics, chronic conditions, and functional limitations to depression. 31522600 2020
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.100 GeneticVariation disease BEFREE To investigate whether baseline concentrations of plasma total tau (t-tau) and neurofilament light (NfL) chain proteins are associated with annual percent change (APC) of the basal forebrain cholinergic system (BFCS) in cognitively intact older adults at risk for Alzheimer disease (AD). 31801830 2020
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.100 Biomarker disease BEFREE Only NF-L differed between all stages within the AD continuum. 31668967 2020
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
0.100 AlteredExpression disease BEFREE Serum neurofilament light chain levels were higher in ALS patients than in controls (P < 0.0001). 31437330 2020
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.100 Biomarker disease BEFREE Cerebrospinal fluid (CSF) levels of two soluble biomarkers, glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL), have been shown to associate with multiple sclerosis (MS) disease progression. 30570436 2020
CUI: C0027765
Disease: nervous system disorder
nervous system disorder
0.100 Biomarker group BEFREE Neurofilament light distinguished neurodegenerative or neurological disorder from psychiatric disorder with an area under the curve of 0.94 (95% confidence intervals = [0.89, 0.98]); a cut-off of 1332 pg/mL was associated with 87% sensitivity and 90% specificity. 31220922 2020
CUI: C0027765
Disease: nervous system disorder
nervous system disorder
0.100 Biomarker group BEFREE Neurofilament light chain (NfL) is a unique biomarker related to axonal damage and neural cell death, which is elevated in a number of neurological disorders, and can be detected in cerebrospinal fluid (CSF), as well as blood, serum, or plasma samples. 31385229 2020
CUI: C0524851
Disease: Neurodegenerative Disorders
Neurodegenerative Disorders
0.100 Biomarker group BEFREE This cross-sectional retrospective pilot study assessed cerebrospinal fluid neurofilament light on patients referred to a tertiary neuropsychiatry service from 2009 to 2017 for diagnostic assessment of neuropsychiatric and neurocognitive symptoms, where a neurodegenerative disorder was a differential diagnosis, who received lumbar punctures as part of a comprehensive workup. 31220922 2020
Multiple Sclerosis, Relapsing-Remitting
0.070 Biomarker disease BEFREE Circulating levels of neurofilament light chain (NfL) are a biomarker of disease activity in RRMS. 31657006 2020
CUI: C0004936
Disease: Mental disorders
Mental disorders
0.030 Biomarker group BEFREE Neurofilament light distinguished neurodegenerative or neurological disorder from psychiatric disorder with an area under the curve of 0.94 (95% confidence intervals = [0.89, 0.98]); a cut-off of 1332 pg/mL was associated with 87% sensitivity and 90% specificity. 31220922 2020
CUI: C0004936
Disease: Mental disorders
Mental disorders
0.030 Biomarker group BEFREE Serum neurofilament light chain is a discriminative biomarker between frontotemporal lobar degeneration and primary psychiatric disorders. 31595378 2020
CUI: C0026847
Disease: Spinal Muscular Atrophy
Spinal Muscular Atrophy
0.030 Biomarker disease BEFREE Neurofilament light chain in serum of adolescent and adult SMA patients under treatment with nusinersen. 31552549 2020
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.030 Biomarker phenotype BEFREE This study explored the utility of cerebrospinal fluid neurofilament light in distinguishing primary psychiatric disorders from neurodegenerative and neurological disorders, a common diagnostic dilemma for psychiatrists and neurologists. 31220922 2020
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.030 Biomarker phenotype BEFREE Serum neurofilament light chain is a discriminative biomarker between frontotemporal lobar degeneration and primary psychiatric disorders. 31595378 2020
CUI: C0751072
Disease: Frontotemporal Lobar Degeneration
Frontotemporal Lobar Degeneration
0.030 Biomarker disease BEFREE Serum neurofilament light chain is a discriminative biomarker between frontotemporal lobar degeneration and primary psychiatric disorders. 31595378 2020
CUI: C0011206
Disease: Delirium
Delirium
0.020 Biomarker disease BEFREE Neurofilament light rose more sharply in participants with delirium compared to non-sufferers [mean difference (95% CI) = 0.251 (0.136, 0.367) log10 (pg/ml), P < 0.001]. 31802104 2020
CUI: C3811918
Disease: GRN-related frontotemporal dementia
GRN-related frontotemporal dementia
0.020 Biomarker disease BEFREE Serum neurofilament light chain is a discriminative biomarker between frontotemporal lobar degeneration and primary psychiatric disorders. 31595378 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.010 Biomarker disease BEFREE Models examine the relationship of bodily pain, injury as a reason for retirement or not re-signing with a team, length of NFL career, sociodemographic characteristics, chronic conditions, and functional limitations to depression. 31522600 2020
CUI: C0017601
Disease: Glaucoma
Glaucoma
0.010 Biomarker disease BEFREE The NFLP_MD had better diagnostic accuracy than both VF_MD and overall NFL thickness and may be useful for early glaucoma diagnosis. 31770516 2020
CUI: C0027796
Disease: Neuralgia
Neuralgia
0.010 Biomarker phenotype BEFREE Furthermore, the regulatory effect of neurofilament light polypeptide on neuropathic pain was detected using plasmid overexpressing neurofilament light polypeptide. 30987515 2020
CUI: C0030193
Disease: Pain
Pain
0.010 Biomarker phenotype BEFREE The objective of this study was to analyze data from the National Football League Player Care Foundation Study of Retired NFL Players to understand potential risks for depressive symptoms in former athletes by investigating the relationship between pain and depressive symptoms in a multivariate context, while simultaneously exploring the potential connection with functional limitations. 31522600 2020
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.010 GeneticVariation phenotype BEFREE Functional Limitations Mediate the Relationship Between Pain and Depressive Symptoms in Former NFL Athletes. 31522600 2020
Charcot-Marie-Tooth Disease, Type Ia (disorder)
0.010 Biomarker disease BEFREE A recent report (Neurology 2018;90:e518-3524) showed elevation of neurofilament light (NfL) in plasma of CMT1A disease patients, which correlated with disease severity. 31833243 2020
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.010 Biomarker phenotype BEFREE Models examine the relationship of bodily pain, injury as a reason for retirement or not re-signing with a team, length of NFL career, sociodemographic characteristics, chronic conditions, and functional limitations to depression. 31522600 2020
CUI: C3890602
Disease: Bodily Pain
Bodily Pain
0.010 Biomarker phenotype BEFREE Models examine the relationship of bodily pain, injury as a reason for retirement or not re-signing with a team, length of NFL career, sociodemographic characteristics, chronic conditions, and functional limitations to depression. 31522600 2020