NEFL, neurofilament light, 4747

N. diseases: 247; N. variants: 26
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.010 Biomarker disease BEFREE Models examine the relationship of bodily pain, injury as a reason for retirement or not re-signing with a team, length of NFL career, sociodemographic characteristics, chronic conditions, and functional limitations to depression. 31522600 2020
CUI: C0017601
Disease: Glaucoma
Glaucoma
0.010 Biomarker disease BEFREE The NFLP_MD had better diagnostic accuracy than both VF_MD and overall NFL thickness and may be useful for early glaucoma diagnosis. 31770516 2020
CUI: C0027796
Disease: Neuralgia
Neuralgia
0.010 Biomarker phenotype BEFREE Furthermore, the regulatory effect of neurofilament light polypeptide on neuropathic pain was detected using plasmid overexpressing neurofilament light polypeptide. 30987515 2020
CUI: C0030193
Disease: Pain
Pain
0.010 Biomarker phenotype BEFREE The objective of this study was to analyze data from the National Football League Player Care Foundation Study of Retired NFL Players to understand potential risks for depressive symptoms in former athletes by investigating the relationship between pain and depressive symptoms in a multivariate context, while simultaneously exploring the potential connection with functional limitations. 31522600 2020
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.010 GeneticVariation phenotype BEFREE Functional Limitations Mediate the Relationship Between Pain and Depressive Symptoms in Former NFL Athletes. 31522600 2020
Charcot-Marie-Tooth Disease, Type Ia (disorder)
0.010 Biomarker disease BEFREE A recent report (Neurology 2018;90:e518-3524) showed elevation of neurofilament light (NfL) in plasma of CMT1A disease patients, which correlated with disease severity. 31833243 2020
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.010 Biomarker phenotype BEFREE Models examine the relationship of bodily pain, injury as a reason for retirement or not re-signing with a team, length of NFL career, sociodemographic characteristics, chronic conditions, and functional limitations to depression. 31522600 2020
CUI: C3890602
Disease: Bodily Pain
Bodily Pain
0.010 Biomarker phenotype BEFREE Models examine the relationship of bodily pain, injury as a reason for retirement or not re-signing with a team, length of NFL career, sociodemographic characteristics, chronic conditions, and functional limitations to depression. 31522600 2020
CUI: C4543926
Disease: Narcolepsy type 1
Narcolepsy type 1
0.010 Biomarker disease BEFREE The measurement of CSF total-tau, phosphorylated-tau, amyloid-beta 40 and 42, and neurofilament light chain proteins is not informative in NT1. 31552425 2020
CUI: C4721772
Disease: Postoperative delirium
Postoperative delirium
0.010 Biomarker phenotype BEFREE Postoperative delirium is associated with increased plasma neurofilament light. 31802104 2020
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa
0.010 AlteredExpression disease BEFREE To further explore whether AN is associated with neuronal damage, we analysed the levels of neurofilament light chain (NfL), a marker reflecting ongoing neuronal injury, in plasma samples from females with AN, females recovered from AN (AN-REC) and normal-weight age-matched female controls (CTRLS). 31371701 2019
CUI: C0006111
Disease: Brain Diseases
Brain Diseases
0.010 Biomarker group BEFREE Neurofilament light chain (NfL) is a promising blood biomarker to detect neurodegeneration in Alzheimer's disease (AD) and other brain disorders. 31673598 2019
CUI: C0007684
Disease: Central Nervous System Infection
Central Nervous System Infection
0.010 AlteredExpression group BEFREE We aimed to determine if switching from TDF to TAF increases the risk of neuronal injury, by quantifying plasma levels of neurofilament light protein (NfL), a sensitive marker of neuronal injury in HIV CNS infection. 31826005 2019
CUI: C0011303
Disease: Demyelinating Diseases
Demyelinating Diseases
0.010 Biomarker group BEFREE Increased cerebrospinal fluid neurofilament light chain in central nervous system inflammatory demyelinating disease. 30771578 2019
CUI: C0022336
Disease: Creutzfeldt-Jakob disease
Creutzfeldt-Jakob disease
0.010 Biomarker disease BEFREE In CJD, neurogranin positively correlated with tau (r=0.55, p<0.001) and was higher in 14-3-3-positivity (p<0.05), but showed no association with NFL (r=0.08, p=0.46). 31097472 2019
Late-Infantile Neuronal Ceroid Lipfuscinosis
0.010 AlteredExpression disease BEFREE Before treatment in 21 human subjects with CLN2 disease (age range: 1.72-6.85 years), neurofilament light levels were 48-fold higher (P < 0.001) than in 7 pediatric controls (age range: 8-11 years). 31814335 2019
Leukoencephalopathy, Progressive Multifocal
0.010 Biomarker disease BEFREE This study analyzed serum neurofilament light chains (NfL) in 2 European cohorts of 312 multiple sclerosis (MS) patients to investigate whether NfL are biomarkers of progressive multifocal leukoencephalopathy (PML) during natalizumab treatment. 30761586 2019
CUI: C0024408
Disease: Machado-Joseph Disease
Machado-Joseph Disease
0.010 Biomarker disease BEFREE Neurofilament light chain is a promising serum biomarker in spinocerebellar ataxia type 3. 31684998 2019
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.010 GeneticVariation disease BEFREE Our findings suggested that the <i>NEFL</i> rs2979704 T>C polymorphism may be associated with Wilms' tumor susceptibility in the Chinese population. 31057612 2019
CUI: C0027873
Disease: Neuromyelitis Optica
Neuromyelitis Optica
0.010 Biomarker disease BEFREE To test the hypothesis that serum levels of glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL), which are an intermediate astrocyte and neuron filaments, respectively, are clinically useful biomarkers of disease activity and disability in neuromyelitis optica spectrum disorders (NMOSD). 31471502 2019
CUI: C0029134
Disease: Optic Neuritis
Optic Neuritis
0.010 Biomarker disease BEFREE Levels of cytokines and neurofilament light chain (NF-L) were measured at the onset of acute ON and compared to healthy controls (HC). 30857557 2019
CUI: C0085584
Disease: Encephalopathies
Encephalopathies
0.010 Biomarker group BEFREE We aimed at investigating serum neurofilament light (NfL) chain concentration in patients with a postanoxic encephalopathy after CA and its prognostic potential. 31375414 2019
CUI: C0238051
Disease: Cerebral Angiitis
Cerebral Angiitis
0.010 AlteredExpression disease BEFREE CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis. 31211179 2019
CUI: C0268407
Disease: Senile cardiac amyloidosis
Senile cardiac amyloidosis
0.010 Biomarker disease BEFREE Plasma neurofilament light chain concentration is increased and correlates with the severity of neuropathy in hereditary transthyretin amyloidosis. 31583784 2019
CUI: C0338462
Disease: Semantic Dementia
Semantic Dementia
0.010 Biomarker disease BEFREE In different FTLD subtypes, neurofilament light chain (NfL) is a promising marker, therefore we investigated the utility of cerebrospinal fluid (CSF) NfL in SD. 31123142 2019