|
Henoch-Schoenlein Purpura
|
0.010 |
Biomarker
|
disease |
BEFREE |
We here explored Neurofilament light chain (NfL) as a biomarker in HSP.
|
30009206 |
2018 |
|
Spastic Paraplegia, Hereditary
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serum neurofilament light chain is increased in hereditary spastic paraplegias.
|
30009206 |
2018 |
|
Ataxia, Spinocerebellar
|
0.010 |
Biomarker
|
disease |
BEFREE |
Specifically, as a marker of neuronal damage, NfL might (1) help to differentiate multiple system atrophy of cerebellar type (MSA-C) from sporadic adult-onset ataxia (SAOA), and (2) show increases in repeat-expansion spinocerebellar ataxias (SCAs) which might be amenable to treatment in the future.
|
29737427 |
2018 |
|
Intervertebral disc disorder
|
0.010 |
AlteredExpression
|
group |
BEFREE |
CSF NfL levels were significantly higher in MCI-AD/AD-dem and IDD patients as compared with both PD and OND patients.
|
29370869 |
2018 |
|
Dementia due to Parkinson's disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Plasma NFL may represent a biomarker of cognitive decline in AD and PD, with more specificity for AD.
|
30478269 |
2018 |
|
Central nervous system demyelination
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Chitinase 3-like 1 (CHI3L1), neurofilament light chain (NFL) and oligoclonal bands (OCB) in cerebrospinal fluid are associated with central nervous system demyelination in adults.
|
30055504 |
2018 |
|
Motor symptoms
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
High plasma NFL correlated with poor cognition in AD and PD, but not with motor symptoms in PD.
|
30478269 |
2018 |
|
Hypoxic-Ischemic Encephalopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Hypothesis: Raised plasma NFL protein levels from newborns who undergo TH after HIE are associated with abnormal MRI outcomes.
|
29556208 |
2018 |
|
Overactive Bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
To evaluate the effects of a treatment with leuprolide acetate (LA) on bladder overactivity as well as the expression of gonadotropin releasing hormone receptor (GnRH-R), and neurofilaments NF68 and NF200 in female rats with overactive bladder induced by castration.
|
30133853 |
2018 |
|
PNEUMOTHORAX, PRIMARY SPONTANEOUS
|
0.010 |
Biomarker
|
disease |
BEFREE |
CSF neurofilament light chain and phosphorylated tau 181 predict disease progression in PSP.
|
29282336 |
2018 |
|
Peripheral neuropathy due to and following chemotherapy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Neurofilament light chain as disease biomarker in a rodent model of chemotherapy induced peripheral neuropathy.
|
29908147 |
2018 |
|
Deuteranomaly
|
0.010 |
Biomarker
|
disease |
BEFREE |
Neurofilament light chain (NFL) in cerebrospinal fluid (CSF) is a promising biomarker candidate which may discriminate atypical parkinsonian disorders (APD), mainly including multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD), from Parkinson's disease (PD).
|
30036569 |
2018 |
|
Cerebrovascular Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
We compared levels of CSF markers for β-amyloid (Aβ42, Aβ40), total and phosphorylated tau (t-tau and p-tau<sub>181</sub>, respectively), endothelial dysfunction (soluble vascular cell adhesion molecule 1, soluble intercellular adhesion molecule 1), α-synuclein, and neurodegeneration (neurofilament light chain [NfL]), as well as MRI markers, for hippocampal atrophy and cerebrovascular disease (white matter hyperintensity [WMH] volume).
|
29096697 |
2017 |
|
Encephalomyelitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we show that peripheral injections of antibodies to NF-L augmented clinical signs of neurological disease in acute EAE, increased retinal ganglion cell loss in experimental optic neuritis and induced neurological signs following intracerebral injection into control mice.
|
28718500 |
2017 |
|
Muscle Spasticity
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Immunization with neuronal antigens such as neurofilament light (NF-L), a neuronal intermediate filament in axons, has been shown to induce neurological disease and spasticity in mice.
|
28718500 |
2017 |
|
Obesity
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The results of these longitudinal analyses support the utility of the NFL PLAY 60 physical activity promotion programs for improving youth aerobic capacity and potentially helping to reverse the prevalence of overweight/obesity.
|
27919454 |
2017 |
|
Degenerative brain disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
We suggest that factors previously shown to be important for brain degeneration in mild cognitive impairment may also impact changes in normal aging, demonstrating that NFL is likely to indicate AD-independent, age-expected neurodegeneration.
|
27794264 |
2017 |
|
Minimally Conscious State
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To test this hypothesis, we evaluated the cerebrospinal fluid (CSF) level of neurofilament light chain (NF-L), a proposed marker of axonal degeneration, in 10 patients who developed a severe disorder of consciousness after a TBI, including 7 in a minimally conscious state and 3 with unresponsive wakefulness syndrome (time since brain injury, 309 ± 169 days).
|
28385104 |
2017 |
|
Tauopathies
|
0.010 |
Biomarker
|
group |
BEFREE |
Using Western Blot and ELISA we characterized NF-L and disease-related proteins in brain, CSF and plasma samples from Tg4510 mice (tauopathy/AD), MitoPark mice (PD), and their age-matched control littermates.
|
28461218 |
2017 |
|
Progressive multiple sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Neurofilament light chain (NFL), myelin basic protein (MBP), IgG-index, chitinase-3-like-1 (CHI3L1), matrix metalloproteinase-9 (MMP-9), chemokine CXCL13, terminal complement complex, leukocyte counts and nitric oxide metabolites were measured in primary ( n = 26) and secondary progressive MS ( n = 26) and healthy controls ( n = 24).
|
28831853 |
2017 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The clinical records of 105 patients with NFL and a single HCC less than 5 cm in diameter who had undergone curative liver resection between April 2000 and January 2013 were investigated.
|
28099960 |
2017 |
|
HIV-1 infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
Neurofilament light chain protein as a marker of neuronal injury: review of its use in HIV-1 infection and reference values for HIV-negative controls.
|
28598205 |
2017 |
|
Cerebral Small Vessel Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Serum neurofilament light is sensitive to active cerebral small vessel disease.
|
29046363 |
2017 |
|
PARKINSON DISEASE, LATE-ONSET
|
0.010 |
Biomarker
|
disease |
BEFREE |
As a biomarker of axonal injury, neurofilament light chain (NFL) in multiple system atrophy (MSA) patients and Parkinson's disease (PD) patients has been investigated by numerous studies.
|
27896490 |
2017 |
|
Sleep-Disordered Breathing
|
0.010 |
Biomarker
|
disease |
BEFREE |
The IFL cohort was gender and age matched to subjects with OSAS and a cohort where Sleep Disordered Breathing (SBD)/IFL was absent ("Non Flow Limited" or NFL cohort); PTT Arousal index (PTT Ar) defined by number of PTT arousals per hour.
|
27993286 |
2017 |