NEFL, neurofilament light, 4747

N. diseases: 247; N. variants: 26
Disease: Impaired cognition ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.090 Biomarker disease BEFREE Elevated baseline plasma NfL is a prognostic marker of cognitive decline and neuroimaging measures of neurodegeneration, and has similar effect sizes to baseline CSF NfL. 31182505 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.090 Biomarker disease BEFREE Cerebrospinal fluid neurofilament light chain tracks cognitive impairment in multiple sclerosis. 31129709 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.090 AlteredExpression disease BEFREE Does cognitive dysfunction correlate with neurofilament light polypeptide levels in the CSF of patients with multiple sclerosis? 30982375 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.090 Biomarker disease BEFREE Levels of CSF NFL are associated with cognitive impairments in patients with Alzheimer disease and frontotemporal dementia. 30508027 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.090 Biomarker disease BEFREE We demonstrated that plasma Aβ40, Aβ42, t-tau, and NFL may be useful to identify aMCI and correlate with cognitive decline and brain atrophy. 31145586 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.090 AlteredExpression disease BEFREE Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain. 29797629 2018
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.090 AlteredExpression disease BEFREE For all diagnostic groups, higher CSF NfL levels were associated with faster frontal cognitive decline. 30103065 2018
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.090 Biomarker disease BEFREE Plasma NFL may represent a biomarker of cognitive decline in AD and PD, with more specificity for AD. 30478269 2018
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.090 AlteredExpression disease BEFREE NFL levels were able to differentiate sCJD from nonprimarily neurodegenerative neurological and psychiatric diseases (area under the curve = 0.99, 95% confidence interval: 0.99-1) and from the other diagnostic groups showing cognitive impairment/dementia of a non-CJD etiology (area under the curve = 0.90, 95% confidence interval: 0.87-0.92). 29391125 2018