melanoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
This novel mechanism for regulating NF1 in melanoma provides a molecular basis for targeting CAPN1 in order to stabilize NF1 levels and, in doing so, suppressing Ras activation; this mechanism can be exploited therapeutically in melanoma and other cancers.
|
30131853 |
2018 |
melanoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results warrant the clinical investigation of this combination therapy in patients with NF1 mutant melanoma.
|
28143781 |
2017 |
melanoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Melanogenesis in NF1 sets the stage for the discussion on the roles of NF1 and neurofibromin in neural crest-derived neoplasms including melanoma with particular emphasis on NF1 and neurofibromin as markers of melanocyte dedifferentiation in desmoplastic melanoma.
|
27941538 |
2017 |
melanoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
As neurofibromin activity is a key to regulating the RAS/MAPK pathway, NF1 mutations are important in the acquisition of drug resistance, to BRAF, EGFR inhibitors, tamoxifen and retinoic acid in melanoma, lung and breast cancers and neuroblastoma.
|
28637487 |
2017 |
melanoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this article, we review the literature on neurofibromin with special attention to keratinocytes, melanocytes, NF1-related tumors and melanoma.
|
27622733 |
2017 |
melanoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
This review discusses the current knowledge of the NF1 gene and neurofibromin 1 in neurofibromatosis type I and in melanoma.
|
28067895 |
2017 |
melanoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas.
|
26214590 |
2015 |
melanoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The high frequency of NF1 mutations in DMs suggests an important role for NF1 in the biology of this type of melanoma.
|
26076063 |
2015 |
melanoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies.
|
25119042 |
2014 |
melanoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Together these studies provide new insights into the signaling that underlies melanoma initiation and progression and suggests novel therapeutic strategies for patients whose melanomas are BRAF-mutant/NF1-deficient.
|
23475878 |
2013 |
melanoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Collectively, these studies provide mechanistic insight into how NF1 cooperates with BRAF mutations in melanoma and show that NF1/neurofibromin inactivation may have an impact on responses to targeted therapies.
|
23171796 |
2013 |
melanoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Somatic deletion of the NF1 gene in a neurofibromatosis type 1-associated malignant melanoma demonstrated by digital PCR.
|
16961930 |
2006 |
melanoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Eighteen (47%) of uveal melanomas demonstrated weak expression of neurofibromin.
|
12963615 |
2003 |
melanoma
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Eighteen (47%) of uveal melanomas demonstrated weak expression of neurofibromin.
|
12963615 |
2003 |
melanoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Loss of NF1 gene expression has been reported in Schwann cell tumors (neurofibrosarcomas) from patients with NF1 as well as in malignant melanomas and neuroblastomas from patients without NF1.
|
7542904 |
1995 |
melanoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
By transiently coexpressing a neurofibromin cDNA in a melanoma cell line, we show that neurofibromin increases the expression of a reporter gene under the control of the tyrosinase gene promoter.
|
7811291 |
1994 |
melanoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recent studies have demonstrated loss of neurofibromin in tumors from NF1 and non-NF1 patients, including neurofibrosarcomas, neuroblastomas and malignant melanomas.
|
7519874 |
1994 |
melanoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
In contrast to the schwannoma cell lines, GTP-Ras was appropriately regulated in the melanoma and neuroblastoma lines that were deficient in neurofibromin, even when c-H-ras was overexpressed in the lines.
|
8516298 |
1993 |
melanoma
|
0.600 |
CausalMutation
|
disease |
CGI |
|
|
|
melanoma
|
0.600 |
GenomicAlterations
|
disease |
CGI |
|
|
|