Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE Second, gene expression-based subtyping revealed three molecular subsets of KEAP1/NRF2-mutant lung adenocarcinomas and two molecular subsets of KEAP1/NRF2-mutant lung squamous cell carcinomas, each associated with distinguishing genetic, differentiation, immunological and clinicopathological properties. 30411339 2019
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease BEFREE Recent studies have identified a specific gene-expression signature regulated by the Nrf2 pathway in lung adenocarcinoma and head-and-neck squamous cell cancer. 31628914 2019
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE Gene-expression signature regulated by the KEAP1-NRF2-CUL3 axis is associated with a poor prognosis in head and neck squamous cell cancer. 29306329 2018
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease BEFREE The upregulation of Nrf2 was positively correlated with a high incidence of lymph node metastasis and advanced histological grade and TNM stage, but inversely associated with differentiation and survival of OSCC patients. 30231242 2018
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease BEFREE Twenty-eight genes were identified by overlap between LR (291 genes) and SAM (30 genes), and these consistently separated SCC into 2 groups in all datasets, corresponding to putatively NRF pathway-activated and wild-type (WT) tumors.NRF2(ACT) was not prognostic. 25739673 2015
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE Clinical significance of Keap1 and Nrf2 in oral squamous cell carcinoma. 24386210 2013
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE Previously, we reported that NRF2 gene (NFE2L2) mutations correlate with poor prognosis of lung squamous cell carcinomas. 22614957 2012
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE Recently, we reported that NRF2 gene (NFE2L2) mutations are correlated with poor prognosis for lung squamous cell carcinomas. 22767273 2012
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease BEFREE All of the oesophageal SCCs and skin SCCs with the NRF2 mutations showed increased NRF2 expression in the nuclei. 19967722 2010
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease BEFREE In multivariate analysis, Nrf2 expression was associated with worse overall survival [P = 0.0139; hazard ratio (HR), 1.75] in NSCLC patients, and low or absent Keap1 expression was associated with worse overall survival (P = 0.0181; HR, 2.09) in squamous cell carcinoma. 20534738 2010
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease CTD_human Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2. 18572023 2008