NFE2L2, nuclear factor, erythroid 2 like 2, 4780

N. diseases: 823; N. variants: 34
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.570 GeneticVariation disease BEFREE Polymorphism in the Promoter Region of NFE2L2 Gene Is a Genetic Marker of Susceptibility to Cirrhosis Associated with Alcohol Abuse. 31340446 2019
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.570 Biomarker disease BEFREE Therefore, in the present work, the capacity of doxazosin (<i>α</i>1 antagonist), carvedilol (nonselective beta-adrenoceptor blocker with alpha 1-blocking properties), and curcumin (antioxidant and anti-inflammatory compound) to reverse liver cirrhosis and studying the possible modulation of Nrf-2 and NF-<i>κ</i>B were evaluated. 31183386 2019
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.570 Biomarker disease BEFREE Integrated stress response in hepatitis C promotes Nrf2-related chaperone-mediated autophagy: A novel mechanism for host-microbe survival and HCC development in liver cirrhosis. 31386899 2019
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.570 Biomarker disease BEFREE Targeting Keap-1/Nrf-2 pathway and cytoglobin as a potential protective mechanism of diosmin and pentoxifylline against cholestatic liver cirrhosis. 29852187 2018
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.570 AlteredExpression disease BEFREE PBC was associated with reduced Nrf2 expression and autophagy deterioration and these impairments were more advanced in patients with cirrhosis. 28333129 2017
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.570 Biomarker disease BEFREE Finally, we showed the therapeutic importance of targeting Hrd1, rather than Keap1, to prevent Nrf2 loss and suppress liver cirrhosis. 24636985 2014
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.570 Therapeutic disease CTD_human Nuclear erythroid 2-related factor 2: a novel potential therapeutic target for liver fibrosis. 23793039 2013
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.570 AlteredExpression disease BEFREE It remains to be established in further studies if the observed decrease of Nrf2 expression is just a result of liver cirrhosis or is primary, playing a role in disease pathogenesis. 22459801 2012
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.570 Therapeutic disease RGD Anti-fibrotic effects of L-2-oxothiazolidine-4-carboxylic acid via modulation of nuclear factor erythroid 2-related factor 2 in rats. 22732220 2012