|
Pulmonary Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The nuclear factor E2-related factor 2 (Nrf2) plays an important regulatory role in the antioxidant therapy of PQ-induced pulmonary fibrosis.
|
31301076 |
2020 |
|
Pulmonary Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Hesperidin alleviates BLM-induced IPF via inhibition of TGF-β1/Smad3/AMPK and IκBα/NF-κB pathways which in turn ameliorate the modulation of oxido-inflammatory markers (Nrf2 and HO-1) and pro-inflammatory markers (TNF-α, IL-1β, and IL-6) to reduce collagen deposition during pulmonary fibrosis.See also Figure 1(Fig.1).
|
31611754 |
2019 |
|
Pulmonary Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Bleomycin (BLM)-induced PF in Nrf2-knockout (Nrf2<sup>-/-</sup> ) and wild-type (WT) mice and transforming growth factor β1 (TGF-β1)-induced EMT in rat type II alveolar epithelial cell line (RLE-6TN) and human alveolar epithelial cell line (A549) were established to observe the relationship among Nrf2, HMGB1, and EMT by western blot and immunohistochemistry.
|
30370641 |
2019 |
|
Pulmonary Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tanshinone IIA Activates Nuclear Factor-Erythroid 2-Related Factor 2 to Restrain Pulmonary Fibrosis via Regulation of Redox Homeostasis and Glutaminolysis.
|
30105924 |
2019 |
|
Pulmonary Fibrosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Amitriptyline attenuates bleomycin-induced pulmonary fibrosis: modulation of the expression of NF-κβ, iNOS, and Nrf2.
|
30474696 |
2019 |
|
Pulmonary Fibrosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis via the up-regulation of Nrf2.
|
29108993 |
2018 |
|
Pulmonary Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We conclude that FGF21 inhibits pulmonary fibrosis through activating Nrf-2 pathway, subsequently suppressing oxidative stress, inhibiting ECM deposition and pulmonary fibrogenesis, suggesting that FGF21 has potential as therapeutic agent for treatment of pulmonary fibrosis.
|
29864937 |
2018 |
|
Pulmonary Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we observed the effects of Nrf2 pathway and Numb on bleomycin(BLM)-induced PF in Nrf2-knockout (Nrf2<sup>-/-</sup>) and wild-type (WT) mice.
|
29362432 |
2018 |
|
Pulmonary Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We explore the possible discourse of sinapic acid (SA) against the prevention of bleomycin (BLM)-instigated lung fibrosis in rats through modulation of Nrf2/HO-1 and NF-κB signaling pathways.
|
30219680 |
2018 |
|
Pulmonary Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Nuclear Thioredoxin-1 Overexpression Attenuates Alcohol-Mediated Nrf2 Signaling and Lung Fibrosis.
|
27436123 |
2016 |
|
Pulmonary Fibrosis
|
0.600 |
Biomarker
|
disease |
CTD_human |
Suppression of nuclear factor erythroid 2-related factor 2 via extracellular signal-regulated kinase contributes to bleomycin-induced oxidative stress and fibrogenesis.
|
23570914 |
2013 |
|
Pulmonary Fibrosis
|
0.600 |
Biomarker
|
disease |
RGD |
This study demonstrates the involvement of Nrf2-Keap1 signaling through which EGCG enhances antioxidant activities and Phase II enzymes with subsequent restraint inflammation during bleomycin-induced pulmonary fibrosis.
|
19138753 |
2009 |