NFKB1, nuclear factor kappa B subunit 1, 4790

N. diseases: 551; N. variants: 52
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.370 AlteredExpression disease BEFREE Type 2 diabetes is associated with increased expression of APOE, BAX, MMP1, NFKB1, PDGFB, SPP1, and TGFB2. 23337395 2014
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.370 Biomarker group CTD_human Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats. 19028472 2009
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.370 AlteredExpression group LHGDN Morphoproteomic profile of mTOR, Ras/Raf kinase/ERK, and NF-kappaB pathways in human gastric adenocarcinoma. 18715846 2008
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.370 Biomarker group LHGDN Use of bioluminescent imaging to investigate the role of nuclear factor-kappaBeta in experimental non-small cell lung cancer metastasis. 18008176 2008
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.370 AlteredExpression group LHGDN EGF-R is expressed and AP-1 and NF-kappaB are activated in stromal myofibroblasts surrounding colon adenocarcinomas paralleling expression of COX-2 and VEGF. 18032824 2007
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.370 GeneticVariation group LHGDN Clinical biology of esophageal adenocarcinoma after surgery is influenced by nuclear factor-kappaB expression. 17548685 2007
Diabetes Mellitus, Non-Insulin-Dependent
0.370 Biomarker disease CTD_human Molecular epidemiologic evidence for diabetogenic effects of dioxin exposure in U.S. Air force veterans of the Vietnam war. 17107852 2006
Diabetes Mellitus, Non-Insulin-Dependent
0.370 GeneticVariation disease BEFREE We examined the CA repeat polymorphism of the NFKB1 gene (encoding for NFkappaB) and A/G point variation in the 3'UTR region of the nuclear factor kappa B inhibitor alpha (NFKBIA) gene (encoding for IkappaB) in Czech and German patients with type 2 diabetes. 17002901 2006
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.370 Biomarker group LHGDN Expression of nuclear factor-kappa B and I kappa B alpha proteins in prostatic adenocarcinomas: correlation of nuclear factor-kappa B immunoreactivity with disease recurrence. 15073126 2004
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.370 AlteredExpression group LHGDN NF-kappaB-dependent MnSOD expression protects adenocarcinoma cells from TNF-alpha-induced apoptosis. 12032830 2002
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.350 GeneticVariation disease BEFREE The present study analyzed potential relationships between alcoholism or alcoholic liver disease (ALD) and IL12B 2124 G>T (rs1368439), IL16 5000 C>T (rs1131445), IL1R1 3114 C>T (rs3917328), and NFKB1 3400 A>G (rs4648143) polymorphisms. 29566963 2018
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.350 Biomarker disease PSYGENET Transcriptional control of maladaptive and protective responses in alcoholics: a role of the NF-κB system. 21195164 2011
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.350 GeneticVariation disease BEFREE Polymorphisms of human NF-κB1 and other innate immune genes contribute to genetic risk for alcoholism. 21402143 2011
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.350 GeneticVariation disease BEFREE We found an association between the presence of the deletion allele in NFKB1 polymorphism and ALC in patients with alcohol dependence. 19673747 2009
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.350 Biomarker disease PSYGENET We found an association between the presence of the deletion allele in NFKB1 polymorphism and ALC in patients with alcohol dependence. 19673747 2009
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.350 GeneticVariation disease LHGDN NF-kappaB regulates many genes relevant to brain function, and its actions can be potentiated by ethanol; thus, NFKB1 is an excellent candidate gene for alcoholism. 18079108 2008
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.350 Biomarker disease PSYGENET NF-kappaB regulates many genes relevant to brain function, and its actions can be potentiated by ethanol; thus, NFKB1 is an excellent candidate gene for alcoholism. 18079108 2008
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.350 Biomarker disease BEFREE NF-kappaB regulates many genes relevant to brain function, and its actions can be potentiated by ethanol; thus, NFKB1 is an excellent candidate gene for alcoholism. 18079108 2008
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.350 AlteredExpression disease BEFREE Alterations in expression of p50 homodimer/NF-kappaB regulated genes may contribute to neuroplastic adaptation underlying alcoholism. 17895971 2007
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.350 Biomarker disease PSYGENET Alterations in expression of p50 homodimer/NF-kappaB regulated genes may contribute to neuroplastic adaptation underlying alcoholism. 17895971 2007
CUI: C0023895
Disease: Liver diseases
Liver diseases
0.340 Biomarker group BEFREE Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases. 30070632 2018
CUI: C0023895
Disease: Liver diseases
Liver diseases
0.340 AlteredExpression group BEFREE However, M120 V mutation may utilize a different pathway in liver disease progression that involves high expression of NF-κB subunit, p50. 29652648 2018
CUI: C0023895
Disease: Liver diseases
Liver diseases
0.340 GeneticVariation group BEFREE In this case-control study, 559 subjects (343 patients with HCV infection including 237 mild chronic hepatitis patients and 106 patients with Advanced Liver Disease (AdLD), 78 individuals who naturally cleared HCV and 138 healthy subjects) were genotyped for the NFκB1 and NFκBIA SNPs using PCR-RFLP. 26827631 2016
CUI: C0023895
Disease: Liver diseases
Liver diseases
0.340 GeneticVariation group BEFREE A total of 258 male alcoholics (161 without liver disease and 97 with ALC) and 101 healthy controls were genotyped for the -94ins/delATTG NFKB1, 3'-UTR+126G>A NFKBIA, and 34C>G PPARG2 polymorphisms. 19673747 2009
CUI: C0023895
Disease: Liver diseases
Liver diseases
0.340 Therapeutic group CTD_human Taken together these data indicate that the p50 NF-kappaB subunit plays a critical protective role in the injured liver by limiting the expression of TNF-alpha and its recruitment of inflammatory cells. 15743782 2005