NFKB1, nuclear factor kappa B subunit 1, 4790

N. diseases: 551; N. variants: 52
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023895
Disease: Liver diseases
Liver diseases
0.340 Biomarker group BEFREE Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases. 30070632 2018
CUI: C0023895
Disease: Liver diseases
Liver diseases
0.340 AlteredExpression group BEFREE However, M120 V mutation may utilize a different pathway in liver disease progression that involves high expression of NF-κB subunit, p50. 29652648 2018
CUI: C0023895
Disease: Liver diseases
Liver diseases
0.340 GeneticVariation group BEFREE In this case-control study, 559 subjects (343 patients with HCV infection including 237 mild chronic hepatitis patients and 106 patients with Advanced Liver Disease (AdLD), 78 individuals who naturally cleared HCV and 138 healthy subjects) were genotyped for the NFκB1 and NFκBIA SNPs using PCR-RFLP. 26827631 2016
CUI: C0023895
Disease: Liver diseases
Liver diseases
0.340 GeneticVariation group BEFREE A total of 258 male alcoholics (161 without liver disease and 97 with ALC) and 101 healthy controls were genotyped for the -94ins/delATTG NFKB1, 3'-UTR+126G>A NFKBIA, and 34C>G PPARG2 polymorphisms. 19673747 2009
CUI: C0023895
Disease: Liver diseases
Liver diseases
0.340 Therapeutic group CTD_human Taken together these data indicate that the p50 NF-kappaB subunit plays a critical protective role in the injured liver by limiting the expression of TNF-alpha and its recruitment of inflammatory cells. 15743782 2005