|
Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, to understand the influence of HSP90 inhibitors on neurons, we investigated the effects of geldanamycin, an HSP90 antagonist, on nerve growth factor (NGF)-differentiated pheochromocytoma 12 (PC12) cells, particularly, on the expression and phosphorylation of proteins and kinases in the NGF pathway.
|
31402210 |
2019 |
|
Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study explored whether vasoinhibin affects the neurotrophic actions of NGF by measuring the cell differentiation and survival of PC12 pheochromocytoma cells.
|
31091528 |
2019 |
|
Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we have characterized in nerve growth factor-differentiated pheochromocytoma PC12 cells injured with hypoxia: (i) the effects of PEMF exposure on cell vitality; (ii) the protective pathways activated by PEMFs to relief neuronal cell death, including adenylyl cyclase, phospholipase C, protein kinase C epsilon and delta, p38, ERK1/2, JNK1/2 mitogen-activated protein kinases, Akt and caspase-3; (iii) the regulation by PEMFs of prosurvival heat-shock proteins of 70 (HSP70), cAMP response element-binding protein (CREB), brain-derived neurotrophic factor (BDNF), and Bcl-2 family proteins.
|
30656694 |
2019 |
|
Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
All isolates were evaluated for their effects on nerve growth factor (NGF)-mediated neurite outgrowth in pheochromocytoma (PC12) cells.
|
31030559 |
2019 |
|
Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immobilized NGF induced neurite outgrowth of PC12 cells, a cell line derived from a pheochromocytoma of the rat adrenal medulla, at the same level as soluble NGF.
|
31571871 |
2019 |
|
Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we examine the uptake of nerve growth factor (NGF) by a pheochromocytoma PC12 cell line cultured using two Campenot-like device designs, a "Standard" layout, representative of a commercial device, and a custom "Notch" layout, predicted to encourage more efficient nutrient transfer that gives rise to sustained neuron viability and extensive neurite elaboration.
|
30885631 |
2019 |
|
Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To study the function of GPR143, we investigated the phenotypic effect of overexpression of GPR143 in pheochromocytoma (PC12) cells treated with nerve growth factor.
|
31606330 |
2019 |
|
Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nerve growth factor (NGF)-differentiated rat neuronal pheochromocytoma PC-12 cells were untreated/treated with statins alone or together with non-sterol isoprenoids.
|
30909654 |
2019 |
|
Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Single-stranded DNA enhances nerve growth factor-induced MMP9-dependent neurite extension in pheochromocytoma 12 cells providing evidence for potential biological significance of the nucleotide-mediated allosteric enhancement of the catalytic activity.
|
29654109 |
2018 |
|
Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The main objective of this study was to fabricate aligned polyurethane nanofibers by electrospinning process and decorate them with gold nanoparticles to further investigate the synergistic effects of nanotopography, biological nerve growth factor (NGF) and electrical stimulations on neurite outgrowth and elongation of pheochromocytoma (PC-12) model cells.
|
29427534 |
2018 |
|
Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Traditionally, neurite outgrowth assessment has been conducted on immortalized cell lines such as pheochromocytoma (PC-12) cells that differentiate into neuron-like cells upon culture with nerve growth factor.
|
29222785 |
2018 |
|
Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In nerve growth factor (NGF) induced differentiated PC12 pheochromocytoma cells, we demonstrated that the denatured Tat-SOD regained its antioxidant activity and effectively protected PC12 cells from DNA fragmentation induced by paraquat.
|
26786970 |
2016 |
|
Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pheochromocytoma and neuroblastoma arise from neural crest progenitors that compete for growth factors such as nerve growth factor (NGF) during development.
|
24469107 |
2014 |
|
Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cytotoxic derivatives of somatostatin AN-238 and, to a lesser extent, AN-162, reduced cell numbers of uninduced and NGF-induced adrenomedullary pheochromocytoma cells and adrenocortical cancer cells.
|
19717419 |
2009 |
|
Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Conversely, VPA had no effect on cell proliferation of human CCF astrocytoma cells but stimulated nerve growth factor (NGF)-induced neurite outgrowth from rat PC12 pheochromocytoma cells.
|
19766605 |
2009 |
|
Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Notably, supernatants of eosinophils stimulated with IgA immune complex and interleukin 5 promote neurite extension of the PC-12 pheochromocytoma cell line; this effect is abolished by pretreatment of the supernatants with anti-NGF-neutralizing antibody.
|
11877300 |
2002 |
|
Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
NID67, a small putative membrane protein, is preferentially induced by NGF in PC12 pheochromocytoma cells.
|
11288140 |
2001 |
|
Pheochromocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Nerve growth factor- and epidermal growth factor-regulated gene transcription in PC12 pheochromocytoma and INS-1 insulinoma cells.
|
11152283 |
2000 |
|
Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human neuroblastoma SH-SY5Y and IMR32 cells and rat phaeochromocytoma PC12 cells were used as an in vitro system for neuronal differentiation and were induced to differentiate in the presence of retinoic acid, a combination of dibutyryl cAMP and 5-bromodeoxyuridine, and nerve growth factor respectively.
|
8963445 |
1996 |
|
Pheochromocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The promoter region(s) involved in induction of interleukin 1 alpha expression by nerve growth factor in PC12 pheochromocytoma cells were studied by deletion mutagenesis in a part of the 5' regulatory region of the human interleukin 1 alpha gene (bases -163 to +64).
|
8939459 |
1996 |
|
Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
K-252a has been reported to specifically inhibit the effects of NGF on PC12 pheochromocytoma cells.
|
1702431 |
1991 |
|
Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, NGF could be chemically cross-linked to the endogenous gp140trk present in rat PC12 pheochromocytoma cells as well as to gp140trk ectopically expressed in mouse fibroblasts and in insect Sf9 cells.
|
1849459 |
1991 |
|
Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this report, we describe the transfection of the nerve growth factor (NGF)-responsive pheochromocytoma cell line PC12 with the human GAP-43 cDNA under the control of the Moloney murine leukemia virus long terminal repeat (MoMuLV LTR).
|
2153893 |
1990 |
|
Pheochromocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The cells which comprise the adrenal nodules resemble those in the parent tumor of the rat PC12 pheochromocytoma cell line in that they show varying degrees of spontaneous or nerve growth factor-induced neurite outgrowth in culture and they contain little or no epinephrine.
|
2864475 |
1985 |