NINJ2, ninjurin 2, 4815

N. diseases: 20; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023508
Disease: White Blood Cell Count procedure
White Blood Cell Count procedure
0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 Biomarker disease BEFREE Mutations in gene locations of CDKN2B-AS1 (Rs2383206), HDAC9 (Rs11984041), NINJ2 (Rs12425791), NAA25 (Rs17696736) are not risk factors for ischemic stroke in childhood. 30656483 2019
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 GeneticVariation disease BEFREE Consequently, the present case-control study supports the role of NINJ2 as a risk locus for ischemic stroke in Iranian population. 31372770 2019
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 GeneticVariation disease BEFREE Thus, we carried out a meta-analysis to identify the association between nerve injury-induced protein 2 (NINJ2) gene polymorphisms (rs11833579 and rs12425791) and the risk of IS. 31258083 2019
CUI: C0032181
Disease: Platelet Count measurement
Platelet Count measurement
0.100 GeneticVariation phenotype GWASCAT Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. 29403010 2018
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 Biomarker disease BEFREE However, the underlying mechanisms of NINJ2 in ischemic stroke or atherosclerosis are still unknown. 28431986 2017
CUI: C0032181
Disease: Platelet Count measurement
Platelet Count measurement
0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C0200635
Disease: Lymphocyte Count measurement
Lymphocyte Count measurement
0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C0200637
Disease: Monocyte count procedure
Monocyte count procedure
0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C0750880
Disease: Monocyte count result
Monocyte count result
0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
Platelet Component Distribution Width Measurement
0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 GeneticVariation disease BEFREE Common and rare variants in the NINJ2 region were nominally associated with incident ischemic stroke among a subset of CHARGE participants. 24959832 2014
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 GeneticVariation disease BEFREE A GWAS found that the single-nucleotide polymorphism rs11833579 near the NINJ2 gene on chromosome 12p13 was associated with an increased risk of ischemic stroke in Caucasians in 2009. 25096477 2014
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 GeneticVariation disease BEFREE Significant allelic association was identified between NINJ2 gene rs11833579 (P = 0.008), protein kinase C η gene rs2230501 (P = 0.039) and IS. 24664524 2014
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 GeneticVariation disease BEFREE Association between 12p13 SNPs rs11833579/rs12425791 near NINJ2 gene and ischemic stroke in East Asian population: evidence from a meta-analysis. 22297388 2012
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 GeneticVariation disease BEFREE In 2009, a GWAS has confirmed that rs11833579 and rs12425791 near the NINJ2 gene could increase the stroke and ischemic stroke (IS) risk. 22795341 2012
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 GeneticVariation disease BEFREE No evidence for association of 12p13 SNPs rs11833579 and rs12425791 within NINJ2 gene with ischemic stroke in Chinese Han population. 21376321 2011
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 GeneticVariation disease BEFREE Therefore, we report a new genetic variant, rs10849373, located in the first intron of the NINJ2 gene, conferring risk of ischemic stroke in Chinese Han subjects. 21722921 2011
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.080 GeneticVariation group BEFREE Among the acknowledged risk factors of stroke are the single nucleotide polymorphisms (SNPs) near Ninjurin 2 (NINJ2) gene which encodes a surface adhesion protein. 31372770 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.080 GeneticVariation group BEFREE Previous genetic studies suggested that variants in NINJ2 (encode ninjurin2) confer risk to ischemic stroke or large artery atherosclerotic stroke. 28431986 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.080 GeneticVariation group BEFREE Other loci associated with stroke in previous studies, including NINJ2, were not confirmed. 26708676 2016
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.080 GeneticVariation group BEFREE In 2009, a genome-wide association study (GWAS) identified two variants (rs12425791 and rs11833579) near NINJ2 gene that confer susceptibility to stroke in Caucasian populations. 26312640 2016
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.080 GeneticVariation group BEFREE Further validation of the functionality of the NINJ2 rs3809263 G > A polymorphism and its association with risk of LAA stroke in other ethnic populations is warranted. 26687183 2016
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.080 GeneticVariation group BEFREE In 2009, a GWAS has confirmed that rs11833579 and rs12425791 near the NINJ2 gene could increase the stroke and ischemic stroke (IS) risk. 22795341 2012
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.080 GeneticVariation group BEFREE Recent genome-wide association (GWA) studies have identified two intergenic single nucleotide polymorphisms (SNPs) (rs11833579 and rs12425791) on chromosome 12p13 and within 11 kb of the NINJ2 gene that were significantly associated with stroke in Caucasians. 21376321 2011