|
Acute Erythroblastic Leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
On the other hand, in the differentiation of the erythroleukemia line K562 by hemin, levels of both mRNA and protein of Nm23-H1 elevated transiently, then reduced to the original level.
|
8058309 |
1994 |
|
Acute Erythroblastic Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Differentiation inhibitory factor (nm23 protein) inhibited the induction of differentiation of mouse myeloid leukemia M1 and WEHI-3BD+ and human erythroleukemia HEL, KU812, and K562 cells.
|
8896423 |
1996 |
|
Acute lymphocytic leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
On the other hand, NM23-H1 protein expression was maintained in leukaemic cells in 50% of both low and medium/high risk ALL cases.
|
11299850 |
2001 |
|
Acute lymphocytic leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Serum nm23-HI levels were significantly higher in patients with all of the hematological neoplasms tested (AML, chronic myelogenous leukemia, acute lymphoblastic leukemia, (ALL) myelodysplastic syndrome (MDS) and malignant lymphomas) than in normal controls.
|
12153176 |
2002 |
|
Acute lymphocytic leukemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
This finding suggests that nm23-H1 mutations may be a rare event in ALL.
|
9891483 |
1999 |
|
Acute Megakaryocytic Leukemias
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of nm23-H1 mRNA and the levels of protein during induced differentiation of human leukemia cell lines were analysed. mRNA levels of the megakaryoblastic leukemia line MEG-01, which were induced to differentiate into megakaryocyte by TPA, decreased rapidly from 2 days after the start of treatment and became almost undetectable at day 4.
|
8058309 |
1994 |
|
Acute monocytic leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Among AMLs, acute monocytic leukemia (presentation with AML-M5 morphology) was especially associated with elevated nm23-H1 and -H2 mRNA levels.
|
8896423 |
1996 |
|
Acute monocytic leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We recently reported that nm23 genes were overexpressed in acute myelogenous leukemia (AML), and a higher level of nm23-H1 expression was correlated with a poor prognosis in AML, especially in AML-M5 (acute monocytic leukemia).
|
9490665 |
1998 |
|
Acute monocytic/monoblastic leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We recently reported that nm23 genes were overexpressed in acute myelogenous leukemia (AML), and a higher level of nm23-H1 expression was correlated with a poor prognosis in AML, especially in AML-M5 (acute monocytic leukemia).
|
9490665 |
1998 |
|
Acute monocytic/monoblastic leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The present results indicate that nm23-H1 and -H2 are overexpressed in AML and especially nm23-H1 gene expression predicts the prognosis of AML, especially of AML-M5.
|
8896423 |
1996 |
|
Acute Promyelocytic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Similar down-regulation of nm23-H1 mRNA was also observed in the induced differentiation of the promyelocytic leukemia line HL-60 by TPA, or DMSO into monocyte-macrophage lineage or granulocytes, respectively.
|
8058309 |
1994 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Among the proteins that were identified, Rho GDP dissociation inhibitor 2, alpha-enolase, Lamin A/C, and nucleoside-diphosphate kinase A were demonstrated to be up-regulated in both mRNA and protein expression in esophageal adenocarcinomas relative to Barrett metaplasia.
|
16829691 |
2007 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Although genetic alterations in nm23-H1 have recently been described in those colorectal adenocarcinomas which give rise to distant metastases, we were unable to detect any mutation in the coding sequence of nm23-H1 in the metastatic tissue itself.
|
7981087 |
1994 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of nm23-H1 in prostatic intraepithelial neoplasia and adenocarcinoma.
|
8892585 |
1996 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of nm23-H1 was detected in 46% of adenocarcinoma and in 36% of squamous cell carcinoma of the uterine cervix, whereas c-erbB-2 expression was evident in 49% and 38%, respectively.
|
7736397 |
1995 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
No significant correlation was found between nm23 staining and any clinicopathologic parameters in NE carcinoma or in adenocarcinoma.
|
8569178 |
1996 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Semiquantitative immunoblot analysis of nm23-H1 and -H2 isoforms in adenocarcinomas of the lung: prognostic significance.
|
10792783 |
2000 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
A total of 162 pulmonary adenocarcinomas resected between 1980 and 1991 were stained using monoclonal antibodies to nm23 (NCL-nm23), c-erbB-2 (NCL-CB11) and p53 (DAKO Do7).
|
9196297 |
1997 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Nm23-H1 deletions were relatively more frequent in poorly differentiated adenocarcinomas (P = 0.03).
|
8199988 |
1994 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of nm23 mRNA in the tissues of gastric and colorectal adenocarcinoma was not significantly different from that in the normal tissues adjacent to cancer (P>0.05), and was not associated with the invasion of tumor and the pathology grade of adenocarcinoma (P>0.05).
|
16425351 |
2005 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genetic alterations either as a deletion in the coding sequence of nm23-H1 or as an allelic deletion were detected in four among eight colorectal adenocarcinomas associated with metastases in lymph nodes, lung, or liver.
|
7916650 |
1993 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In the present study, levels of NDP kinase/nm23 gene product in curatively resected human pancreatic adenocarcinomas were examined immunohistochemically using anti-NDP kinase antibody.
|
8383029 |
1993 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A total of 55 specimens from patients with epithelial ovarian cancers, 15 patients with serous cancers, 7 with mucinous cancers, 17 with endometrioid cancers and 16 with adenocarcinomas, were examined for the expression of nm23-H1 by means of the immunohistochemical technique.
|
9594287 |
1997 |
|
Adenocarcinoma of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
nm23-H1 expression and loss of heterozygosity in colon adenocarcinoma.
|
15563674 |
2004 |
|
Adenocarcinoma of large intestine
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, the expression of nm23 mRNA was correlated negatively to the lymph node metastasis of gastric and colorectal adenocarcinoma (r = -0.49, P<0.01; r = -4.93, P<0.01).
|
16425351 |
2005 |