Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.100 AlteredExpression disease BEFREE Coimmunoprecipitation and confocal microscopy studies using SCC9-P and various epithelial cell lines with endogenous plakoglobin expression revealed that Nm23 interacts with plakoglobin, cadherins and alpha-catenin. 20101217 2010
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.100 AlteredExpression disease BEFREE We found normal cervix and CIN 1 samples had concurrent low expression of hTERT and nm23-H1, whereas high-grade CIN and SCC samples had concurrent high immunoreactivities. 17359290 2007
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.100 AlteredExpression disease BEFREE A linear decrease (p = 0.001) was observed in nm23-H1 expression, starting from CIN1 (85% with normal expression), with the most dramatic down regulation on transition from CIN2 (70% normal) to CIN3 (39%) and further to SCC (25%). 16537673 2006
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.100 AlteredExpression disease BEFREE NM-23 gene loss of heterozygosity and protein expression in high-stage laryngeal squamous cell carcinomas. 16531762 2006
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.100 AlteredExpression disease BEFREE In addition, our results further indicated cigarette smoking could aggravate the extent of nm23-H1 expression and possibly disease progression of OSCC patients. 15150613 2004
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.100 AlteredExpression disease BEFREE These findings suggest that nm23-H1 inhibits the invasive activity of oral squamous cell carcinoma by suppression of cell motility without altering the MMP-2 and MMP-9 status. 11337376 2001
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.100 AlteredExpression disease BEFREE This pilot study examines the expression of the nm23 gene product compared with nodal status in 70 consecutive patients with squamous cell carcinomas of the head and neck. 10629490 2000
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.100 AlteredExpression disease BEFREE The metastasis suppressor activity of nm23/nucleoside diphosphate (NDP) kinase was assessed using human oral squamous cell carcinoma (SCC) cell lines. 10632374 1999
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.100 AlteredExpression disease BEFREE The NM23 gene and its expression in oral squamous cell carcinoma. 10373649 1999
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.100 Biomarker disease BEFREE Thus we have a strong hint that the nm23 protein is secreted by the bronchogenic squamous cell carcinoma. 9080143 1997
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.100 Biomarker disease BEFREE Overexpression of nucleoside diphosphate/kinase A/nm23-H1 protein in human lung tumors: association with tumor progression in squamous carcinoma. 8569178 1996
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.100 AlteredExpression disease BEFREE Furthermore in stage I and II, poorly differentiated squamous cell carcinomas contained significantly more nm23 mRNA than did moderately differentiated ones (p < 0.027). 7863493 1994
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.100 Biomarker disease BEFREE Frequent loss of heterozygosity for Rb, TP53, and chromosome arm 3p, but not NME1 in squamous cell carcinomas of the supraglottic larynx. 8174043 1994
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.100 AlteredExpression disease BEFREE There was no statistically significant trend in tumour staining from keratoacanthoma through decreasing grades of differentiation of squamous cell carcinoma. nm23 product expression does not appear to correlate with differentiation, itself an indicator of metastatic potential, in this system of human squamous cell neoplasms.(ABSTRACT TRUNCATED AT 250 WORDS) 8358113 1993
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.100 AlteredExpression disease BEFREE The increases in nm23 mRNA expression were stronger in advanced stages of squamous-cell carcinoma, large-cell carcinoma, sarcoma and carcinoids than in early stages of the respective tumor types. 8375920 1993