|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Individual cells within melanoma sphere cultures displayed a wide range of NME1 expression across multiple melanoma cell lines.
|
31123173 |
2019 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of the metastasis suppressor NME1 in melanoma is associated with reduced cellular motility, invasion, and metastasis, but mechanisms underlying these activities are not completely understood.
|
30458180 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of a gene expression signature associated with the metastasis suppressor function of NME1: prognostic value in human melanoma.
|
29058705 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Much of the attention has been focused on the metastasis-suppressing role of NDPK-A in human tumors, including breast carcinoma and melanoma.
|
28991262 |
2018 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Correspondingly, numerous invasive cancer cell lines (eg, breast, colon, oral, hepatocellular carcinoma, and melanoma) display low endogenous NM23 levels.
|
28920944 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We previously identified NME1-regulated genes with prognostic value in human melanoma.
|
30396920 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this review, we summarize how the HGF/SF transgenic mouse has been used to reveal metastasis-regulating activity of four different genes (<i>CDK4</i><sup>R24C</sup>, <i>survivin</i> and <i>NME1/NME2</i>) in the context of UV-induced melanoma.
|
28788083 |
2017 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of NME1 strongly suppressed cell motility in melanoma cell lines 1205LU and M14.
|
25808322 |
2015 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, a number of the NME1-regulated genes were shown to be of prognostic value for distant disease-free survival and overall survival in melanoma and breast cancer.
|
25048347 |
2015 |
|
melanoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Forced NME1 expression in a variety of melanoma-derived cell lines was shown to induce dynamic changes in cell morphology and reorganization of the actin cytoskeleton, with formation of a network of thick stress fibers and assembly of fibronectin fibrils at large focal adhesions.
|
25017017 |
2015 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Importantly, the invasion- and metastasis-promoting activity of c-Abl/Arg is dependent on their ability to induce NM23-H1 degradation, and the pathway is clinically relevant as c-Abl/Arg activity and NM23-H1 expression are inversely correlated in primary breast cancers and melanomas.
|
24096484 |
2014 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These studies demonstrate for the first time in vivo a potent metastasis suppressor activity of NM23 in UVR-induced melanoma, and have provided new tools for identifying molecular mechanisms that underlie melanoma metastasis.
|
22699362 |
2013 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Although forced expression of NM23-H1 potently suppressed spontaneous lung metastasis of subcutaneous tumor explants derived from the human melanoma cell line 1205LU, no significant metastasis suppressor activity was obtained with the exonuclease-deficient variants E(5) A and K(12) Q.
|
20209495 |
2011 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This report outlines recent findings from our laboratory indicating that the metastasis suppressor function of NM23-H1 in human melanoma involves a spectrum of molecular mechanisms.
|
21448569 |
2011 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Of the genes identified, seven genes: galectin 3 (Lgals3), melanoma cell adhesion molecule (Mcam), fibronectin 1 (Fn1), signal transducer and activator of transcription 3 (Stat3), microphthalmia-associated transcription factor (Mitf), max interacting protein 1 (Max1), and non-metastatic cells 1, protein (NM23A) expressed in (Nme1) are known to be associated with melanoma, but have not yet been reported as being regulated by hypoxia in human melanoma cells.
|
21912348 |
2011 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nm23-H1 has been identified as a metastatic suppressor gene in murine melanoma cell lines.
|
21553004 |
2011 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of Nm23-H1 in metastatic cell lines (melanoma, breast carcinoma, prostate, colon, hepatocellular, and oral squamous cell carcinoma) reduced cell motility in in vitro assays and metastatic potential in xenograft models, without a significant effect on primary tumor size.
|
21713383 |
2011 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To assess the relevance of the 3'-5' exonuclease activity of NM23-H1 to its antimutator and metastasis suppressor functions, a panel of mutants harboring defects in the 3'-5' exonuclease and other enzymatic activities of the molecule (NDPK, histidine kinase) have been expressed by stable transfection in the melanoma cell line, 1205Lu.
|
17039395 |
2006 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
DNA sequences acting as binding sites for NM23/NDPK proteins in melanoma M14 cells.
|
16440314 |
2006 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Reductions in nm23 expression have been significantly associated with aggressive behavior in melanoma, breast, colon, and gastric carcinomas.
|
17197349 |
2006 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Relationship of nm23 expression to proliferation and prognosis in malignant melanomas of the oral cavity.
|
16277028 |
2005 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Some experimental studies demonstrated a significantly reduced metastatic potential of melanoma cell lines transfected with the nm23 gene.
|
11744991 |
2002 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Several studies on human breast, hepatocellular, gastric, ovarian, and colon carcinomas and melanomas have shown that reduced nm23-H1 expression was closely related to metastatic progression with poor prognosis.
|
11337376 |
2001 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
From a series of tumor cohort studies, low expression of Nm23/NDP kinase has been correlated with poor patient prognosis and survival, lymph node infiltration, and histopathological indicators of high metastatic potential in a number of cancer types, including mammary and ovarian carcinomas and melanoma.
|
11768314 |
2000 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To determine whether metastasis-related functions of NDPKs are mediated by their catalytic activity in membrane bound or soluble complexes, we have stably transfected highly metastatic human melanoma Line IV Cl 1 cells with wild-type and catalytically inactive (H118Y) nm23-H1 and nm23-H2 genes and assayed their metastatic potential in nude mice.
|
11058869 |
2000 |