Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We identified high NM23 expression levels that have a diagnostic accuracy in HCC tissues and had a poor recurrence-free survival in HBV-related HCC patients.
|
30662464 |
2018 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Proteomic analysis of 12 tumours from an mTOR-driven hepatocellular carcinoma mouse model revealed that NME1 and NME2, the only known mammalian histidine kinases, were upregulated.
|
29562234 |
2018 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A panel of 12 genes (e.g., HSP90β, ERG1, GPC3, TKT, ACLY, and NME1 for HCC; SPT2, T4S3, CNX43, TTD1, HBD01 for CC) were detected and partly described for the first time as potential discrimination markers.
|
29271183 |
2018 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
There is abundant mRNA expression of NM23-H1, NM23-H2, or a read through transcript (NM23-LV) in the primary sites of hepatocellular carcinoma (HCC).
|
22192927 |
2012 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Evidence for a metastasis suppressor function of NME1 in vivo comes from crossing NME1 (-/-) mice with mice prone to develop hepatocellular carcinoma; the double transgenic mice present a higher incidence of lung metastases.
|
21562815 |
2011 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We silenced NM23-H1 expression in human hepatoma and colon carcinoma cells and methodologically investigated effects on cell-cell adhesion, migration, invasion, and signaling linked to cancer progression.
|
20841469 |
2010 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Nm23-H1 suppresses hepatocarcinoma cell adhesion and migration on fibronectin by modulating glycosylation of integrin beta1.
|
20618991 |
2010 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Reduced expression of these genes coincident with elevated Nm23-H1 expression was observed in human breast tumor cohorts, a panel of breast carcinoma cell lines, and hepatocellular carcinomas from control versus Nm23-M1 knockout mice.
|
17671192 |
2007 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The demonstration of a causative role of NM23 in metastatic dissemination in a mouse model of hepatocarcinoma suggests that hepatocarcinoma-derived cells could be good models for the analysis of the molecular mechanisms involved in NM23 action.
|
16944304 |
2006 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The positive expression rate of nm23-H1 protein in HCC tissue was significantly lower than that in corresponding non-cancerous or normal liver tissue (45.5, 72.7, 88.9%, P < 0.05). nm23-H1 expression was not related with the size of tumor, envelope formation, AFP level, HBsAg state, cirrhosis of liver, Edmondson grade, and TNM stage (P > 0.05).
|
15761980 |
2005 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Lycopene inhibits cell migration and invasion and upregulates Nm23-H1 in a highly invasive hepatocarcinoma, SK-Hep-1 cells.
|
16140886 |
2005 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
After transfection of nm23-H1 into 7721 human hepatocarcinoma cells and A549 human lung cancer cells, the activities of GnT-V were decreased by 28%-42% in the cells.
|
10972975 |
2000 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Effects of all-trans retinoic acid and epidermal growth factor on the expression of nm23-H1 in human hepatocarcinoma cells.
|
10664247 |
2000 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of nm23/tissue inhibitor of metalloproteinase (TIMP)-2 was positively associated with the prognosis of HCC patients (Log-rank, P < 0.001).
|
10374394 |
1998 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that: (i) the expression of nm23-H1 protein is inversely associated with high metastatic potential of HCC, (ii) regulation of nm23-H1 expression may occasionally occur at both the transcriptional and post-transcriptional levels in HCC; and (iii) genomic alteration of nm23-H1 is a rare event in HCC.
|
9658316 |
1998 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, nm23-H1 mRNA abundance may be a predictor of intrahepatic metastasis, the most important factor correlated with the metastatic potential of hepatocellular carcinoma.
|
7530600 |
1995 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increased invasive activity of human hepatocellular carcinoma cells is associated with an overexpression of thyroid hormone beta 1 nuclear receptor and low expression of the anti-metastatic nm23 gene.
|
8529211 |
1995 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Nm23-H1 gene expression is inversely correlated with tumor metastatic potential in certain tumors, including melanomas, breast carcinomas, and hepatocellular carcinomas.
|
8270257 |
1994 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
However, the authors observed an inverse relationship between nm23-H1 expression and intrahepatic metastases of hepatocellular carcinomas.
|
8168032 |
1994 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
nm23 mRNA overexpression in small solitary hepatocellular carcinoma is associated with a lower recurrence rate after surgical resection, suggesting that this gene may participate in the metastatic dissemination of this neoplasm.
|
8039626 |
1994 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Gene expression of nm23 has been investigated in number of tumors, including breast cancer, colon cancer, malignant melanoma, and hepatocellular carcinoma.
|
8293386 |
1994 |