Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker disease BEFREE Also discussed are the NDPK-A relevant molecular determinants of neuroblastoma metastasis, and metastasis-relevant neural crest development. 28991262 2018
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker disease BEFREE Moreover, blockage of the Nm23-H1/h-Prune interaction with a competitive permeable peptide (CPP) attenuates migration of breast and neuroblastoma cells. 25138575 2015
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker disease BEFREE Meta-analysis performed on three Neuroblastoma cohorts showed Nm23-H1 as the gene highly associated to Neuroblastoma aggressiveness. 23448979 2013
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE While in breast cancer, NM23-H1 overexpression indicates a benign status through impairing progression of disease, its function is opposite in other cancers; e.g., neuroblastoma. 21553004 2011
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 GeneticVariation disease BEFREE Aggregation of the neuroblastoma-associated mutant (S120G) of the human nucleoside diphosphate kinase-A/NM23-H1 into amyloid fibrils. 21484438 2011
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 GeneticVariation disease BEFREE Protein phosphorylation corrects the folding defect of the neuroblastoma (S120G) mutant of human nucleoside diphosphate kinase A/Nm23-H1. 17155928 2007
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE On the contrary, high levels of nm23 gene expression are noted in the advanced stage of thyroid carcinomas and associated with significant reductions in survival for neuroblastoma and osteosarcoma patients. 17197349 2006
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE Neuroblastoma tumors show high-level expression of NM23-H1 and-H2 as well as NM23-LV mRNA. 16442775 2006
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE Serum NM23-H1 protein levels may contribute to predictions of clinical outcome in patients with neuroblastoma. 16232196 2005
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 GeneticVariation disease BEFREE Compared with its wild-type, NDPK-A(S120G) appears more effective in promoting neuroblastoma metastasis. 15280446 2004
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 GeneticVariation disease BEFREE However, the k-pn type proline-96 to serine (P96S) and neuroblastoma type serine-120 to glycine (S120G) mutations of Nm23-H1 abrogated its inhibitory activity on colonization and invasion. 12859952 2003
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE Our findings suggest that nm23-H1 and nm23-H2 expression is increased by 17q gain in neuroblastoma and can be further up-regulated by myc overexpression. 11960382 2002
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 GeneticVariation disease BEFREE Prune protein interacts with the metastasis suppressor nm23-H1, but shows impaired affinity towards the nm23-H1 S120G mutant associated with advanced neuroblastoma. 11687967 2001
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker disease BEFREE Our findings suggest that differentiation associated functions of nm23 proteins in IMR-32 neuroblastoma cells are carried out by bound nm23-1 proteins docked in a limited number of nm23-1 specific sites. 10928103 2000
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 GeneticVariation disease BEFREE Moreover, like the Killer-of-prune mutation in Drosophila NDK and the neuroblastoma Ser120 --> Gly mutation in human NDK-A/Nm23-H1, the Ser122 --> Pro substitution in NDK-B affects the stability of the protein toward heat and urea. 10400630 1999
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker disease BEFREE Since nm23 gene family members have been proposed to play a role in cellular differentiation, as well as in metastasis suppression, we investigated whether and how DR-nm23, a recently identified third member of the human nm23 gene family, might be involved in neuroblastoma differentiation. 9293921 1997
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 GeneticVariation disease BEFREE A point mutation of human nucleoside diphosphate kinase A found in aggressive neuroblastoma affects protein folding. 9188446 1997
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker disease BEFREE The altered properties of the mutant protein may have relevance to a role for NDPK A in neuroblastoma progression. 8637723 1996
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE Thus, ovarian carcinoma seems to belong to the group of tumours, like colon carcinoma and neuroblastoma, in which nm23 overexpression is associated with a more malignant phenotype. 8702236 1996
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE However, in colorectal carcinoma and neuroblastoma, increased levels of nm23 H1 nucleoside diphosphate kinase A (NDPKA) mRNA are associated with tumorigenesis. 8738406 1996
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 GeneticVariation disease BEFREE A similar ser120-gly mutation in NME1 has been found in human neuroblastoma, suggesting that mutation in this region may be a general phenomenon related to tumor progression. 7794272 1995
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression disease BEFREE Elevated neuroblastoma nm23 RNA levels were associated with significant reductions in patient survival in the overall (n = 75) and N-myc non-amplified (n = 61) portion of the cohort. 8384356 1993
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker disease BEFREE Our findings indicate that, in contrast to a proposed role for nm23-H1 as a tumor metastasis suppressor, increased p19/nm23 protein in neuroblastoma is correlated with features of the disease that are associated with aggressive tumors. 2056128 1991