NOS1, nitric oxide synthase 1, 4842

N. diseases: 521; N. variants: 38
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.700 Biomarker disease BEFREE Schizophreniform disorder, DD and PD-NOS constituted 6.4%, 2.8% and 7.5%, respectively, of all probands with a registry diagnosis of schizophrenia. 7676834 1995
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.700 Biomarker disease BEFREE This region has been of significant interest to psychiatric genetics as it contains the Darier's disease locus and other proposed susceptibility genes (e.g., DAO, NOS1), and it has been linked to affective disorders and schizophrenia in multiple populations. 26440917 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.700 GeneticVariation disease BEFREE Collectively these findings suggest that regulatory polymorphisms of NOS1 contribute to the genetic risk for SCZ, and modulate prefrontal brain functioning. 16389274 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.700 Biomarker disease BEFREE Our results strongly support a previous hypothesis that NOS1 contributes to the genetic risk of schizophrenia and suggest that further research on more NOS1 variants and its regular elements are warranted. 18544180 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.700 Biomarker disease CTD_human Altered expression of genes involved in GABAergic transmission and neuromodulation of granule cell activity in the cerebellum of schizophrenia patients. 18923069 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.700 Biomarker disease RGD Information processing deficits and nitric oxide signalling in the phencyclidine model of schizophrenia. 20802999 2010
CUI: C0014848
Disease: Esophageal Achalasia
Esophageal Achalasia 		0.520 Biomarker disease MGD Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice. 8667023 1996
CUI: C0014848
Disease: Esophageal Achalasia
Esophageal Achalasia 		0.520 Biomarker disease MGD Vasculoprotective roles of neuronal nitric oxide synthase. 12397095 2002
CUI: C0014848
Disease: Esophageal Achalasia
Esophageal Achalasia 		0.520 Biomarker disease MGD Nocturnal motor coordination deficits in neuronal nitric oxide synthase knock-out mice. 10077313 1999
CUI: C0014848
Disease: Esophageal Achalasia
Esophageal Achalasia 		0.520 Biomarker disease BEFREE The finding recapitulates the previously reported phenotype of nitric oxide synthase 1-deficient mice, which have achalasia. 25479138 2015
CUI: C0014848
Disease: Esophageal Achalasia
Esophageal Achalasia 		0.520 Biomarker disease MGD Carbon monoxide and nitric oxide as coneurotransmitters in the enteric nervous system: evidence from genomic deletion of biosynthetic enzymes. 10677545 2000
CUI: C0014848
Disease: Esophageal Achalasia
Esophageal Achalasia 		0.520 Biomarker disease MGD Attenuation of activity-induced increases in cerebellar blood flow in mice lacking neuronal nitric oxide synthase. 12623792 2003
CUI: C0014848
Disease: Esophageal Achalasia
Esophageal Achalasia 		0.520 Biomarker disease MGD Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. 7522345 1994
CUI: C0014848
Disease: Esophageal Achalasia
Esophageal Achalasia 		0.520 Biomarker disease MGD Infarct size and nitric oxide synthase in murine myocardium. 10652188 2000
CUI: C0014848
Disease: Esophageal Achalasia
Esophageal Achalasia 		0.520 Biomarker disease MGD Lower esophageal sphincter is achalasic in nNOS(-/-) and hypotensive in W/W(v) mutant mice. 11438492 2001
CUI: C0014848
Disease: Esophageal Achalasia
Esophageal Achalasia 		0.520 Biomarker disease MGD Cortical interneurons become activated by deafferentation and instruct the apoptosis of pyramidal neurons. 15381772 2004
CUI: C0014848
Disease: Esophageal Achalasia
Esophageal Achalasia 		0.520 Biomarker disease MGD Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice. 10362674 1999
CUI: C0014848
Disease: Esophageal Achalasia
Esophageal Achalasia 		0.520 Biomarker disease MGD Effects of nitric oxide synthase gene knockout on neurotransmitter release in vivo. 9692709 1998
CUI: C0014848
Disease: Esophageal Achalasia
Esophageal Achalasia 		0.520 Biomarker disease MGD Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance. 10905473 2000
CUI: C0014848
Disease: Esophageal Achalasia
Esophageal Achalasia 		0.520 Biomarker disease MGD Neuronal NOS provides nitrergic inhibitory neurotransmitter in mouse lower esophageal sphincter. 10444441 1999
CUI: C0014848
Disease: Esophageal Achalasia
Esophageal Achalasia 		0.520 Biomarker disease MGD Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS. 7518615 1994
CUI: C0014848
Disease: Esophageal Achalasia
Esophageal Achalasia 		0.520 Biomarker disease MGD Absence of cerebellar long-term depression in mice lacking neuronal nitric oxide synthase. 10456061 1999
CUI: C0014848
Disease: Esophageal Achalasia
Esophageal Achalasia 		0.520 Biomarker disease MGD Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms. 16024729 2005
CUI: C0014848
Disease: Esophageal Achalasia
Esophageal Achalasia 		0.520 GeneticVariation disease BEFREE To assess whether some functional polymorphisms in the nNOS, iNOS, or eNOS genes are involved in susceptibility to suffer from achalasia. 16848803 2006
CUI: C0014848
Disease: Esophageal Achalasia
Esophageal Achalasia 		0.520 GermlineCausalMutation disease ORPHANET The finding recapitulates the previously reported phenotype of nitric oxide synthase 1-deficient mice, which have achalasia. 25479138 2015