Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Nanoparticles harboring iNOS plasmids (constitutively active cytomegalovirus [CMV]-driven or transcriptionally regulated human osteocalcin [hOC]-driven) evoked iNOS protein expression and nitrite accumulation and impaired clonogenicity in the highly aggressive MDA-MB-231 human breast cancer model.
|
28325291 |
2017 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
The elucidation of these and other NO-driven pathways implicates NOS2 as a key driver of breast cancer disease progression and provides a new perspective in the identification of novel targets that may be therapeutically beneficial in the treatment of estrogen receptor-negative disease.Antioxid.Redox Signal.26, 1044-1058.
|
27464521 |
2017 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
NOS inhibitors and RNA editing modulators may offer novel treatment options for metaplastic breast cancer.
|
28040796 |
2017 |
Malignant neoplasm of breast
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We evaluated dietary factors associated with oxidative balance, DDIT4 (one SNP), FLT1 (35 SNPs), HIF1A (four SNPs), KDR (19 SNPs), MPO (one SNP), NOS2A (15 SNPs), TEK (40 SNPs) and VEGFA (eight SNPs) and breast cancer risk among Hispanic (2,111 cases and 2,597 controls) and non-Hispanic white (1,481 cases and 1,586 controls) women in the Breast Cancer Health Disparities Study.
|
23832257 |
2014 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
We have recently reported that inducible nitric oxide synthase (NOS2) is a strong predictor of survival in patients with estrogen receptor negative [ER(-)] breast cancer, and that NOS2 expression is correlated with a basal-like phenotype.
|
21893353 |
2011 |
Malignant neoplasm of breast
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Evaluation of a multi-functional nanocarrier for targeted breast cancer iNOS gene therapy.
|
21134429 |
2011 |
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
To investigate whether NOS2 levels influence survival of breast cancer patients, we examined NOS2 expression and its association with tumor markers and survival in 248 breast tumors.
|
20978357 |
2010 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
CTD_human |
Nitric oxide produced by inducible nitric oxide synthase is associated with mammary tumorigenesis in irradiated rats.
|
15631943 |
2005 |
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
To examine these results in further detail, the effect of progesterone (Pg) and 17beta-oestradiol (E2) on NOSII expression was analysed in the human breast cancer cell line MCF-7.
|
15778733 |
2005 |
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Some studies showed a positive correlation between the level of NOS protein and progression of malignancy in human breast cancer.
|
15375508 |
2004 |
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Finally, we did not find the up-regulation of NOS isoforms during NSCLC progression that has been suggested for gynaecological and breast cancers.
|
9683299 |
1998 |
Malignant neoplasm of breast
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|