Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The carriage of a mutant allele in the -954 NOS2 gene may have a protective effect on malaria among Southern Ghanaian children.
|
30118498 |
2018 |
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, we experimentally elucidate that iNOS promoter polymorphisms are associated with risk of malaria; employing mutation specific genotyping, functional interplay using western blot and RT-PCR, quantitative estimation of NO, total antioxidant content (TAC) and reactive oxygen species (ROS).
|
29268202 |
2018 |
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Inducible nitric oxide synthase 2 (NOS2 -954 G>C; rs 1800482) heterozygosity was associated with lower incidence of malaria in all age groups {Adjusted incident rates ratio (aIRR) 0.59; 95% CI [0.386-0.887]; P = 0.012)}.
|
28793894 |
2017 |
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A GTGTGTC haplotype consisting of IL-1A (rs17561), IL-4 (rs2243250), TNF (rs1800750), IL-4R (rs1805015), NOS (rs8078340), CD40LG (rs1126535), and LUC7L (rs1211375) was significantly associated with the prevalence of malaria (POR: 1.822, 95% CI: 0.998-3.324).
|
26448013 |
2015 |
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A population of 267 individuals from Brazilian Amazon exposed to malaria was genotyped for five single nucleotide polymorphisms (SNPs), IFNG + 874 T/A, IL10A-1082G/A, IL10A-592A/C, IL10A-819 T/C and NOS2A-954G/C.
|
25627396 |
2015 |
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The peculiar allele distribution found for several NOS alleles could be due to malaria infection that may have contributed to their frequencies, but we cannot exclude that the peculiar allele distribution of NOS might also be due to genetic drift, emphasized by isolation and founder effect.
|
24573959 |
2014 |
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the role of NOS2 polymorphisms on NO bioavailability and on susceptibility to infection, Plasmodium carrier status and clinical malaria.
|
24379293 |
2014 |
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The study confirms the known protective effect of HbS against severe malaria and also reveals a protective effect of SNPs in the nitrogen oxide synthase 2 (NOS2) gene against malaria infection, anaemia and uncomplicated malaria.
|
24934404 |
2014 |
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Taken together, these studies suggest that the relationship between NOS2 promoter polymorphisms and malaria severity is more complex than previously described.
|
19859740 |
2010 |
Malaria
|
0.400 |
Biomarker
|
disease |
BEFREE |
Nitric oxide (NO), derived from catalysis of inducible NO synthase (iNOS), limits malaria parasite growth in mammals.
|
17920060 |
2008 |
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that iNOS promoter haplotypes rather than single nucleotide polymorphisms are associated with malaria in Ghanaian children.
|
15482399 |
2004 |
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No statistically significant association was found between MBL, TNFalpha(-308), or NOS2 polymorphisms and asymptomatic malaria.
|
12641410 |
2003 |
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the inducible nitric oxide synthase gene (NOS2) promoter have been associated with clinical outcome from malaria.
|
14740870 |
2003 |
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We identified a novel single nucleotide polymorphism, -1173 C-->T, in the NOS2 promoter that was significantly associated with protection from symptomatic malaria (odds ratio 0.12, 95% CI 0.03-0.48, p=0.0006) in 179 Tanzanian children, and significantly associated with protection from severe malarial anaemia (adjusted relative risk 0.25, 95% CI 0.09-0.66, p=0.0005) in 1106 Kenyan children studied over 5 years.
|
12433515 |
2002 |
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The single nucleotide substitution, -954G-->C, in the iNOS promoter was rare in Thai patients with malaria.
|
12195390 |
2002 |
Malaria
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Systemic nitric oxide production in human malaria. II. Analysis of mononuclear cell nitric oxide synthase type 2 antigen expression.
|
12125143 |
2002 |
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Nitric oxide synthase 2(Lambaréné) (G-954C), increased nitric oxide production, and protection against malaria.
|
11443559 |
2001 |
Malaria
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Markedly higher iNOS RNA levels were observed in samples of patients with uncomplicated malaria than in patients with severe and complicated malaria.
|
10603415 |
2000 |
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Two recent reports from Gabon and Gambia identified associations of malaria disease severity with the inducible NO synthase (NOS2) promoter G-954C and short allele (<11 repeats) pentanucleotide microsatellite polymorphisms, respectively.
|
10558957 |
1999 |
Malaria
|
0.400 |
Biomarker
|
disease |
CTD_human |
|
|
|