NOS2, nitric oxide synthase 2, 4843

N. diseases: 783; N. variants: 28
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024530
Disease: Malaria
Malaria
0.400 GeneticVariation disease BEFREE The carriage of a mutant allele in the -954 NOS2 gene may have a protective effect on malaria among Southern Ghanaian children. 30118498 2018
CUI: C0024530
Disease: Malaria
Malaria
0.400 GeneticVariation disease BEFREE Here, we experimentally elucidate that iNOS promoter polymorphisms are associated with risk of malaria; employing mutation specific genotyping, functional interplay using western blot and RT-PCR, quantitative estimation of NO, total antioxidant content (TAC) and reactive oxygen species (ROS). 29268202 2018
CUI: C0024530
Disease: Malaria
Malaria
0.400 GeneticVariation disease BEFREE Inducible nitric oxide synthase 2 (NOS2 -954 G>C; rs 1800482) heterozygosity was associated with lower incidence of malaria in all age groups {Adjusted incident rates ratio (aIRR) 0.59; 95% CI [0.386-0.887]; P = 0.012)}. 28793894 2017
CUI: C0024530
Disease: Malaria
Malaria
0.400 GeneticVariation disease BEFREE A GTGTGTC haplotype consisting of IL-1A (rs17561), IL-4 (rs2243250), TNF (rs1800750), IL-4R (rs1805015), NOS (rs8078340), CD40LG (rs1126535), and LUC7L (rs1211375) was significantly associated with the prevalence of malaria (POR: 1.822, 95% CI: 0.998-3.324). 26448013 2015
CUI: C0024530
Disease: Malaria
Malaria
0.400 GeneticVariation disease BEFREE A population of 267 individuals from Brazilian Amazon exposed to malaria was genotyped for five single nucleotide polymorphisms (SNPs), IFNG + 874 T/A, IL10A-1082G/A, IL10A-592A/C, IL10A-819 T/C and NOS2A-954G/C. 25627396 2015
CUI: C0024530
Disease: Malaria
Malaria
0.400 GeneticVariation disease BEFREE The peculiar allele distribution found for several NOS alleles could be due to malaria infection that may have contributed to their frequencies, but we cannot exclude that the peculiar allele distribution of NOS might also be due to genetic drift, emphasized by isolation and founder effect. 24573959 2014
CUI: C0024530
Disease: Malaria
Malaria
0.400 GeneticVariation disease BEFREE We analyzed the role of NOS2 polymorphisms on NO bioavailability and on susceptibility to infection, Plasmodium carrier status and clinical malaria. 24379293 2014
CUI: C0024530
Disease: Malaria
Malaria
0.400 GeneticVariation disease BEFREE The study confirms the known protective effect of HbS against severe malaria and also reveals a protective effect of SNPs in the nitrogen oxide synthase 2 (NOS2) gene against malaria infection, anaemia and uncomplicated malaria. 24934404 2014
CUI: C0024530
Disease: Malaria
Malaria
0.400 GeneticVariation disease BEFREE Taken together, these studies suggest that the relationship between NOS2 promoter polymorphisms and malaria severity is more complex than previously described. 19859740 2010
CUI: C0024530
Disease: Malaria
Malaria
0.400 Biomarker disease BEFREE Nitric oxide (NO), derived from catalysis of inducible NO synthase (iNOS), limits malaria parasite growth in mammals. 17920060 2008
CUI: C0024530
Disease: Malaria
Malaria
0.400 GeneticVariation disease BEFREE These findings suggest that iNOS promoter haplotypes rather than single nucleotide polymorphisms are associated with malaria in Ghanaian children. 15482399 2004
CUI: C0024530
Disease: Malaria
Malaria
0.400 GeneticVariation disease BEFREE No statistically significant association was found between MBL, TNFalpha(-308), or NOS2 polymorphisms and asymptomatic malaria. 12641410 2003
CUI: C0024530
Disease: Malaria
Malaria
0.400 GeneticVariation disease BEFREE Polymorphisms in the inducible nitric oxide synthase gene (NOS2) promoter have been associated with clinical outcome from malaria. 14740870 2003
CUI: C0024530
Disease: Malaria
Malaria
0.400 GeneticVariation disease BEFREE We identified a novel single nucleotide polymorphism, -1173 C-->T, in the NOS2 promoter that was significantly associated with protection from symptomatic malaria (odds ratio 0.12, 95% CI 0.03-0.48, p=0.0006) in 179 Tanzanian children, and significantly associated with protection from severe malarial anaemia (adjusted relative risk 0.25, 95% CI 0.09-0.66, p=0.0005) in 1106 Kenyan children studied over 5 years. 12433515 2002
CUI: C0024530
Disease: Malaria
Malaria
0.400 GeneticVariation disease BEFREE The single nucleotide substitution, -954G-->C, in the iNOS promoter was rare in Thai patients with malaria. 12195390 2002
CUI: C0024530
Disease: Malaria
Malaria
0.400 AlteredExpression disease LHGDN Systemic nitric oxide production in human malaria. II. Analysis of mononuclear cell nitric oxide synthase type 2 antigen expression. 12125143 2002
CUI: C0024530
Disease: Malaria
Malaria
0.400 GeneticVariation disease BEFREE Nitric oxide synthase 2(Lambaréné) (G-954C), increased nitric oxide production, and protection against malaria. 11443559 2001
CUI: C0024530
Disease: Malaria
Malaria
0.400 AlteredExpression disease BEFREE Markedly higher iNOS RNA levels were observed in samples of patients with uncomplicated malaria than in patients with severe and complicated malaria. 10603415 2000
CUI: C0024530
Disease: Malaria
Malaria
0.400 GeneticVariation disease BEFREE Two recent reports from Gabon and Gambia identified associations of malaria disease severity with the inducible NO synthase (NOS2) promoter G-954C and short allele (<11 repeats) pentanucleotide microsatellite polymorphisms, respectively. 10558957 1999
CUI: C0024530
Disease: Malaria
Malaria
0.400 Biomarker disease CTD_human