Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
In this study, associations between CVDs and polymorphisms of angiotensin-converting enzyme (ACE), atrial natriuretic peptide (ANP), beta(2)-adrenal receptor (B2AR) and endothelial nitric oxide synthase (ENOS) genes were explored in a community-based setting.
|
17243909 |
2007 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Endothelial nitric oxide synthase (eNOS) gene polymorphisms have been associated with the pathogenesis of cardiovascular diseases, but few studies have evaluated the role of eNOS haplotypes on the risk and prognosis of heart failure (HF).
|
22290017 |
2012 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
LHGDN |
An endothelial nitric oxide synthase (eNOS) gene polymorphism (Glu298Asp) has been associated with cardiovascular disease.
|
12065317 |
2002 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Concomitant presence of CETP B1, NOS3 T and ANGPTL8 T alleles augments the risk of CVD and T2DM.
|
29973202 |
2018 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
We sought to determine whether the endothelial nitric oxide synthase (eNOS) T-786C single nucleotide polymorphism (SNP), implicated in cardiovascular disease susceptibility, could facilitate differentiation between small (< or =5 mm) versus large (> or =10 mm) ruptured aneurysms.
|
14576373 |
2003 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The distributions of the ecNOS and MTHFR genotypes did not differ significantly between the groups with and without cardiovascular disease.
|
10781649 |
2000 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The susceptibility to nephropathy and CVD depends to some extent on genetic factors, therefore polymorphisms in the gene coding for endothelial NO-synthase, NOS3, can affect the risk of developing these diseases.
|
19246226 |
2009 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
We therefore assessed the association of glaucoma with polymorphisms of NOS3 and CYBA previously associated with cardiovascular disease.
|
22919264 |
2012 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
An insertion/deletion (I/D) polymorphism in the gene encoding the ACE and a single nucleotide exchange polymorphism (G894T) in the gene NOS3 encoding endothelial nitric oxide synthase have been associated with cardiovascular disorders.
|
12837457 |
2003 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
LHGDN |
The present study was performed in an attempt to better understand whether metabolic, endothelial, and angiographic findings characteristic of subjects with cardiovascular disease and in-stent restenosis are related to NOS3 variants.
|
18349107 |
2008 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
A single nucleotide polymorphism G894T within exon 7 of endothelial nitric oxide synthase (eNOS-7) gene, resulting in a replacement of glutamic acid by aspartic acid, has been studied as a putative candidate gene for cardiovascular diseases.
|
21623032 |
2011 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Several polymorphisms in the eNOS gene have been described, some of them being linked with the increased risk of cardiovascular disease, coronary heart disease (CHD), and coronary spasm.
|
19505886 |
2009 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
LHGDN |
The 894T and -786C alleles of the NOS3 gene were significantly associated with both hypertension and CVD in renal allograft recipients.
|
18331440 |
2008 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
However, we found that eNOS G894T polymorphism was associated with the presence and severity of renal disease and with CVD in CRD patients (P=0.028, P=0.018, P=0.016 respectively).
|
19376104 |
2009 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Surprisingly, only approximately half of these studies have demonstrated significant associations between NOS3 polymorphisms and cardiovascular disease, and many reports are contradictory.
|
11431031 |
2001 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The Glu298Asp is a single nucleotide polymorphism (SNP) in the eNOS gene related to the risk of cardiovascular disease.
|
31442681 |
2020 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Biomarkers of CVD risk, plasma fatty acid composition, and NOS3 single nucleotide polymorphism (SNP) genotype (rs11771443, rs1800783, rs1800779, rs1799983, rs3918227, and rs743507) were determined in 450 individuals with the MetS from the LIPGENE dietary intervention cohort.
|
20409549 |
2010 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Specifically, polymorphisms of the endothelial nitric oxide synthase gene (eNOS) have been reported to be associated with multiple health conditions including DR, hypertension, nephropathy, and cardiovascular diseases in several ethnic groups.
|
18079690 |
2007 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Endothelial nitric oxide synthase gene polymorphisms, either independently or through gene environmental interactions, are associated with cardiovascular diseases in multiple ethnic populations.
|
20470943 |
2010 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
However, the genetic background may also affect NO formation in the cardiovascular system, and recent studies have shown that genetic polymorphisms in the eNOS gene modify endogenous NO formation and the risk of developing cardiovascular diseases.
|
20210789 |
2010 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
An endothelial nitric oxide synthase (eNOS) gene polymorphism (Glu298Asp) has been associated with cardiovascular disease.
|
12065317 |
2002 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Our results imply that G894T polymorphism of the endothelial nitric oxide synthase gene is associated with elevated levels of inflammatory and oxidative stress markers, which may partially explain the increased prevalence of G894T polymorphism among patients with cardiovascular disease.
|
15459608 |
2004 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
An interaction between the E298D and T-786C polymorphisms in NOS3, cigarette smoking, and risk of incident coronary heart disease and ischemic stroke events appears to exist, suggesting a potential complex interplay between genetic and environmental factors and cardiovascular disease risk.
|
17108813 |
2006 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Cardiovascular Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Genetic variation of the RAS and NOS3 genes do not appear to strongly influence subclinical cardiovascular disease or blood pressure in this diabetic population.
|
16492203 |
2006 |