|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
However, it is unknown whether eNOS participates in the hypertension-induced pathology of AD.
|
29568075 |
2018 |
|
Alzheimer's Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Therefore, this study aims to examine the relationship between the PIN1 and eNOS genes expression, as well as serum levels and hypertension in Alzheimer's disease sufferers.
|
28506742 |
2017 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The meta-analysis showed that the polymorphism G894T of NOS3 was associated with risk of AD.
|
26337484 |
2015 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggested that the NOS3 Glu298Asp gene polymorphism is not a strong risk factor for AD.
|
23952620 |
2014 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Molecular epidemiologic studies have presented contradictory results concerning a potential role of NOS3 gene G894T polymorphism in AD.
|
20505439 |
2010 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Association between Alzheimer's disease and the NOS3 gene Glu298Asp polymorphism in Chinese.
|
18183499 |
2008 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association between Alzheimer's disease and the NOS3 gene Glu298Asp polymorphism in Chinese.
|
18183499 |
2008 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The influence of APOE epsilon4 and NOS3 G alleles on the risk of AD was independent of homocysteine, vitamin B12 levels and MTHFR status.
|
19169966 |
2008 |
|
Alzheimer's Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The results suggest that increased cerebral expression of NOS3 causes several molecular abnormalities related to AD-type neurodegeneration, including oxidative stress, mitochondrial dysfunction, and impaired acetylcholine homeostasis.
|
17413318 |
2007 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Most genes conferring susceptibility to AD are related to amyloid-beta deposition (APP; PS1; PS2; APOE; Cystatin-C; ubiquilin-1), oxidative stress (NOS2; NOS3) and inflammatory response (IL-1 alpha; IL-1 beta; IL-6; TNF-alpha).
|
17851196 |
2007 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The Glu/Glu genotype at the Glu298Asp variant of the endothelial nitric oxide synthase (NOS3) gene has been tested for association with AD in several Caucasian and Asian populations, with conflicting results.
|
16813604 |
2006 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
CTD_human |
The Glu/Glu genotype at the Glu298Asp variant of the endothelial nitric oxide synthase (NOS3) gene has been tested for association with AD in several Caucasian and Asian populations, with conflicting results.
|
16813604 |
2006 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Influence of the Glu298Asp polymorphism of NOS3 on age at onset and homocysteine levels in AD patients.
|
15718036 |
2005 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The T-786C NOS3 polymorphism in Alzheimer's disease: association and influence on gene expression.
|
15925107 |
2005 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
The endothelial nitric oxide synthase (NOS3) gene encodes endothelial NOS, an enzyme that regulates the production of the vasodilatory nitric oxide associated with the cerebral small vessel pathology observed in early AD.
|
15016421 |
2004 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
No association between Glu298Asp endothelial nitric oxide synthase polymorphism and Italian sporadic Alzheimer's disease.
|
12697290 |
2003 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The nitric oxide synthase-3 codon 298 polymorphism is not associated with late-onset sporadic Alzheimer's dementia and Lewy body disease in a sample from Hungary.
|
14639046 |
2003 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The multifactorial genetic dysfunction in AD includes mutational loci (APP, PS1, PS2) and diverse susceptibility loci (APOE, A2M, AACT, LRP1, IL1A, TNF, ACE, BACE, BCHE, CST3, MTHFR, GSK3B, NOS3) distributed across the human genome, probably converging in common pathogenic mechanisms that lead to premature neuronal death.
|
12452480 |
2002 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently, polymorphisms in the endothelial constitutive nitric oxide synthase 3 (NOS3) and also the inducible nitric oxide synthase gene (NOS2A) have been suggested to lead to increased risk of Alzheimer's disease (AD) or dementia with Lewy bodies.
|
11297817 |
2001 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
No evidence for an association between the Glu298Asp polymorphism of the NOS3 gene and Alzheimer's disease.
|
11041283 |
2000 |
|
Alzheimer's Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Double-labeling studies demonstrated that the low levels of cerebrovascular NOS-III were associated with increased levels of the pro-apoptosis gene product, p53 in smooth muscle and endothelial cells, suggesting a role for altered NOS-III expression in AD-associated vascular degeneration.
|
10818490 |
2000 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
CTD_human |
Association between Alzheimer's disease and the NOS3 gene.
|
10514107 |
1999 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Association between Alzheimer's disease and the NOS3 gene.
|
10514107 |
1999 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|