Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This suggests that eNOS deficiency may elevate aggrecan expression, which promotes apoptosis in VSMC, thereby contributing to atherosclerosis progression.
|
30638179 |
2019 |
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We found that both aberrant expression and dysfunction of eNOS are closely related to AS development, and some new treatment strategies aimed at eNOS have been proposed, including upregulation of eNOS expression and inhibition of eNOS uncoupling.
|
30937466 |
2019 |
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our findings demonstrate that RSV has an effect of activating eNOS expression, contributing to the prevention of dyslipidemia-induced endothelial dysfunction and atherosclerosis.
|
30856465 |
2019 |
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, we investigated whether PDCD5 regulates protein kinase B (PKB/AKT)-endothelial nitric oxide synthase (eNOS)-dependent signal transduction in the endothelium and affects atherosclerosis.
|
29588416 |
2018 |
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To test whether the absence of NO may aggravate atherosclerosis through EMMPRIN activation, double NOS3/apoE knockout (KO) mice expressed high levels of EMMPRIN in carotid plaques, suggesting that targeting extracellular matrix degradation may represent a new mechanism by which endothelial NO prevents atherosclerosis.
|
30347750 |
2018 |
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, OJS has a protective effect on vascular inflammation via eNOS coupling-mediated NO production and might be a potential therapeutic agent for both early and advanced atherosclerosis.
|
30200674 |
2018 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The NOS3 G894T polymorphic variant also correlated with atherosclerosis, an association probably mediated by the traditional risk factors for CVD.
|
29948131 |
2018 |
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Endothelial dysfunction, which is caused by endothelial nitric oxide synthase (eNOS) uncoupling, is an initial step in atherosclerosis.
|
29136955 |
2018 |
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, the aim of our study was to use iTRAQ-based quantitative proteomics to investigate the changes in protein expression in the mitochondrial and cytosolic fractions isolated from the liver of the double (apolipoprotein E (apoE) and eNOS) knockout (apoE/eNOS-DKO) mice as compared to apoE KO mice (apoE<sup>-/-</sup> ) - an animal model of atherosclerosis and hepatic steatosis.
|
29485188 |
2018 |
Atherosclerosis
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
All‑trans retinoic acid reduces endothelin‑1 expression and increases endothelial nitric oxide synthase phosphorylation in rabbits with atherosclerosis.
|
29207193 |
2018 |
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
ApoE<sup>-/-</sup> mice had significantly more atherosclerosis in the aortic root together with increased aortic ROS production, body mass, plasma triglyceride (TG) and total cholesterol (TC) concentration, decreased aortic eNOS expression, and plasma NO concentration.
|
28177681 |
2017 |
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, XMJ recouples eNOS to prevent the growth of atherosclerosis in rats.
|
28252100 |
2017 |
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
These articles described the effects of ESWT on angiogenesis, arteriogenesis, vasculogenesis, endothelial nitric oxide synthase, lower limb micro/macrocirculation, and atherosclerosis.
|
28688873 |
2017 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we analyzed the G894T polymorphism of the eNOS gene in groups of individuals diagnosed with atherosclerosis and in a control group.
|
28481400 |
2017 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We suggest that eNOS intron 4 gene polymorphism is related to endothelial dysfunction and subclinical atherosclerosis and could be a possible genetic marker for prediction of increased susceptibility to cardiovascular complications.
|
25699607 |
2015 |
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of this study is to evaluate the relationship of miR-21, nitric oxide (NOx) and endothelial nitric oxide synthase (eNOS) with subclinical atherosclerosis in carotid arteries by measuring carotid intima media thickness (CIMT) in patients with hypertension and healthy controls.
|
26114349 |
2015 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interaction between the NOS3 gene and obesity as a determinant of risk of type 2 diabetes: the Atherosclerosis Risk in Communities study.
|
24278136 |
2013 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphism of the endothelial nitric oxide synthase (eNOS) affects the pathogenesis of atherosclerosis and associated with premature coronary artery disease (PCAD).
|
23269619 |
2013 |
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Progranulin efficiently inhibited LPS-mediated pro-inflammatory signaling in endothelial cells through activation of the Akt/eNOS pathway and attenuation of the NF-κB pathway, suggesting its protective roles in vascular endothelium against inflammatory reaction underlying atherosclerosis.
|
24098801 |
2013 |
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results highlight NOS1 as a susceptibility factor for stroke, but do not corroborate previous NOS3 association findings with stroke risk. nNOS is known to play a major role in atherosclerosis development and in blood flow regulation, and it is plausible that its influence in stroke may be mediated through these two main clinical risk factors.
|
22153699 |
2012 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The allelic variation (Asp298) of the eNOS gene polymorphism makes individuals vulnerable to the impact of weight on the development of atherosclerosis.
|
22450868 |
2012 |
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mainly expressed in the vascular endothelium, the endothelial NOS isoform (eNOS) plays an important role in the regulation of vascular reactivity and in the development and progression of atherosclerosis.
|
21308339 |
2011 |
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our results reveal that phosphorylation-dependent derepression of HDAC5 mediates flow-induced KLF2 and eNOS expression as well as flow anti-inflammation, and suggest that HDAC5 could be a potential therapeutic target for the prevention of atherosclerosis.
|
20042720 |
2010 |
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Effects of paricalcitol and enalapril on atherosclerotic injury in mouse aortas.
|
20720404 |
2010 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate whether genetic variations in the eNOS gene were associated with intracranial and extracranial atherosclerosis in Koreans.
|
21114134 |
2010 |