Squamous cell carcinoma
|
0.600 |
CausalMutation
|
disease |
CGI |
|
|
|
Squamous cell carcinoma
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Comparing with the alterations at 9q33 to 34.2 regions, LOH at 9q34.3 and methylation of the Notch1 gene was less involved in oral squamous cell carcinomas.
|
17305639 |
2007 |
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In a chemical genetics screen for small molecule activators of Notch signalling, we identified epidermal growth factor receptor (EGFR) as a key negative regulator of Notch1 gene expression in primary human keratinocytes, intact epidermis and skin squamous cell carcinomas (SCCs).
|
18604200 |
2008 |
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
In a chemical genetics screen for small molecule activators of Notch signalling, we identified epidermal growth factor receptor (EGFR) as a key negative regulator of Notch1 gene expression in primary human keratinocytes, intact epidermis and skin squamous cell carcinomas (SCCs).
|
18604200 |
2008 |
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
In contrast, marked Notch 1 staining was observed in extragenital Bowen's disease as well as in genital (penile) human papilloma virus-related in situ and invasive squamous cell carcinomas.
|
18192969 |
2008 |
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
In contrast, marked Notch 1 staining was observed in extragenital Bowen's disease as well as in genital (penile) human papilloma virus-related in situ and invasive squamous cell carcinomas.
|
18192969 |
2008 |
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In addition, Notch1 and Srcasm protein and transcript levels were decreased in human SCCs compared with nonlesional epidermis.
|
19934324 |
2009 |
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These observations suggest that downregulation of Notch1 in oral SCC may be associated with upregulation of EGFR signalling.
|
19398252 |
2010 |
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that DeltaNp63alpha maintains the self-renewing capacity of normal human keratinocytes and cervical cancer cells partly through transcriptional repression of the Notch1 gene and imply a novel pathogenetical significance of frequently observed overexpression of DeltaNp63alpha together with p53 inactivation in SCCs.
|
20442293 |
2010 |
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We conclude that Notch1 expression is associated with cell aggressiveness and 5-FU drug resistance in human esophageal squamous cell carcinoma cell lines in vitro and is significantly associated with a poor survival in human esophageal squamous cell carcinomas.
|
23409141 |
2013 |
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Exome sequencing (n=50) and recurrence testing (n=60) reveals that some significantly and frequently altered genes are specific to OSCC-GB (USP9X, MLL4, ARID2, UNC13C and TRPM3), while some others are shared with HNSCC (for example, TP53, FAT1, CASP8, HRAS and NOTCH1).
|
24292195 |
2013 |
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
This molecular circuitry may inform distinct cell fate decisions to Notch1 in epithelial tissues, where carcinomas such as SCC arise.
|
24525741 |
2014 |
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Frequent mutations in NOTCH1 ligand-binding regions in Japanese oral squamous cell carcinoma.
|
25234595 |
2014 |
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Downmodulation or loss-of-function mutations of the gene encoding NOTCH1 are associated with dysfunctional squamous cell differentiation and development of squamous cell carcinoma (SCC) in skin and internal organs.
|
24743148 |
2014 |
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We used small interfering RNA (siRNA) technology to down-regulate the expression of Notch1 in small cell lung carcinoma (SCLC) cells; H69AR and SBC-3, as well as in non-small cell lung carcinoma (NSCLC) cells; A549 adenocarcinoma (ADC) and H2170 squamous cell carcinoma (SCC).
|
24888228 |
2014 |
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Common and complex Notch1 mutations in Chinese oral squamous cell carcinoma.
|
24277457 |
2014 |
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.
|
25759215 |
2015 |
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Epidermal growth factor receptor inhibition reduces angiogenesis via hypoxia-inducible factor-1α and Notch1 in head neck squamous cell carcinoma.
|
25723392 |
2015 |
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Moreover, based on accumulating structural information of the NOTCH receptor, the functional consequences of NOTCH1 gene mutations identified from diverse SCCs are analyzed, emphasizing loss of function of Notch in these cancers.
|
27228302 |
2016 |
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We found that mRNA high expression level of Notch1 was associated with better overall survival (OS) for all NSCLC patients, hazard ratio (HR) 0.78 (0.69-0.89), p=0.00019, better OS in adenocarcinoma (Ade) patients, HR 0.59 (0.46-0.75), p=1.5e-05, as well as in squamous cell carcinoma (SCC) patients, HR 0.78 (0.62-0.99), p=0.044. mRNA high expression levels of Notch2 and Notch3 were associated with worsen OS for all NSCLC patients, as well as in Ade, but not in SCC patients. mRNA high expression level of Notch4 was not found to be associated with to OS for all NSCLC patients.
|
28061457 |
2017 |
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Notch1 in oral squamous cell carcinoma.
|
27615693 |
2017 |
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Interaction Between Rare Variants in NOTCH1 and Betel Quid Chewing in Oral Squamous Cell Carcinoma.
|
28910158 |
2017 |
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Otherwise, patients with squamous cell carcinoma had relative higher expression of Notch1 and Notch3 expression (<i>p</i> = 0.014 and <i>p</i> = 0.032, respectively).
|
28607605 |
2017 |
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our systematic analysis of proteins and glycoproteins demonstrates changes of protein and glycoprotein relative abundance in SqCC (TP53, U2AF1, and RXR) and in ADC (SMARCA4, NOTCH1, PTEN, and MST1).
|
28814946 |
2017 |
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Expression of p53, p16, cyclin D1, epidermal growth factor receptor and Notch1 in patients with temporal bone squamous cell carcinoma.
|
27488595 |
2017 |