Squamous cell carcinoma
|
0.600 |
CausalMutation
|
disease |
CGI |
|
|
|
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Notch1 in oral squamous cell carcinoma.
|
27615693 |
2017 |
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Notch 1/2 genes play tumor-suppressing functions in squamous cell carcinoma (SCC), a very common malignancy in skin and internal organs.
|
29757189 |
2018 |
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
A mutation in NOTCH1 ligand binding region detected in patients with oral squamous cell carcinoma reduces NOTCH1 oncogenic effect.
|
28791383 |
2017 |
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A novel Notch1 missense mutation (C1133Y) in the Abruptex domain exhibits enhanced proliferation and invasion in oral squamous cell carcinoma.
|
29321718 |
2018 |
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Common and complex Notch1 mutations in Chinese oral squamous cell carcinoma.
|
24277457 |
2014 |
Squamous cell carcinoma
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Comparing with the alterations at 9q33 to 34.2 regions, LOH at 9q34.3 and methylation of the Notch1 gene was less involved in oral squamous cell carcinomas.
|
17305639 |
2007 |
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Downmodulation or loss-of-function mutations of the gene encoding NOTCH1 are associated with dysfunctional squamous cell differentiation and development of squamous cell carcinoma (SCC) in skin and internal organs.
|
24743148 |
2014 |
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Epidermal growth factor receptor inhibition reduces angiogenesis via hypoxia-inducible factor-1α and Notch1 in head neck squamous cell carcinoma.
|
25723392 |
2015 |
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Exome sequencing (n=50) and recurrence testing (n=60) reveals that some significantly and frequently altered genes are specific to OSCC-GB (USP9X, MLL4, ARID2, UNC13C and TRPM3), while some others are shared with HNSCC (for example, TP53, FAT1, CASP8, HRAS and NOTCH1).
|
24292195 |
2013 |
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Expression and oncogenic properties of membranous Notch1 in oral leukoplakia and oral squamous cell carcinoma.
|
29620248 |
2018 |
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Expression of p53, p16, cyclin D1, epidermal growth factor receptor and Notch1 in patients with temporal bone squamous cell carcinoma.
|
27488595 |
2017 |
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Frequent mutations in NOTCH1 ligand-binding regions in Japanese oral squamous cell carcinoma.
|
25234595 |
2014 |
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
High fractions of each of these tumor types were positive for NICD1 in a subset of cells, particularly in basaloid squamous cell carcinomas; however, sequencing of basaloid squamous cell carcinomas failed to identify NOTCH1 mutations.
|
28914715 |
2017 |
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In a chemical genetics screen for small molecule activators of Notch signalling, we identified epidermal growth factor receptor (EGFR) as a key negative regulator of Notch1 gene expression in primary human keratinocytes, intact epidermis and skin squamous cell carcinomas (SCCs).
|
18604200 |
2008 |
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
In a chemical genetics screen for small molecule activators of Notch signalling, we identified epidermal growth factor receptor (EGFR) as a key negative regulator of Notch1 gene expression in primary human keratinocytes, intact epidermis and skin squamous cell carcinomas (SCCs).
|
18604200 |
2008 |
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In addition, Notch1 and Srcasm protein and transcript levels were decreased in human SCCs compared with nonlesional epidermis.
|
19934324 |
2009 |
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
In contrast, marked Notch 1 staining was observed in extragenital Bowen's disease as well as in genital (penile) human papilloma virus-related in situ and invasive squamous cell carcinomas.
|
18192969 |
2008 |
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
In contrast, marked Notch 1 staining was observed in extragenital Bowen's disease as well as in genital (penile) human papilloma virus-related in situ and invasive squamous cell carcinomas.
|
18192969 |
2008 |
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Interaction Between Rare Variants in NOTCH1 and Betel Quid Chewing in Oral Squamous Cell Carcinoma.
|
28910158 |
2017 |
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.
|
25759215 |
2015 |
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
MicroRNA‑495 targets Notch1 to prohibit cell proliferation and invasion in oral squamous cell carcinoma.
|
30387817 |
2019 |
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Moreover, Notch1 is activated in a small subset of SCC cells at the invasive tumor front and predicts for poor prognosis of esophageal SCC, shedding light upon the tumor promoting oncogenic aspect of Notch1 in SCC.
|
29170450 |
2017 |
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Moreover, based on accumulating structural information of the NOTCH receptor, the functional consequences of NOTCH1 gene mutations identified from diverse SCCs are analyzed, emphasizing loss of function of Notch in these cancers.
|
27228302 |
2016 |
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Otherwise, patients with squamous cell carcinoma had relative higher expression of Notch1 and Notch3 expression (<i>p</i> = 0.014 and <i>p</i> = 0.032, respectively).
|
28607605 |
2017 |