NOTCH1, notch receptor 1, 4851

N. diseases: 693; N. variants: 64
Disease: Precursor cell lymphoblastic lymphoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0079748
Disease: Precursor cell lymphoblastic lymphoma
Precursor cell lymphoblastic lymphoma 		0.040 GeneticVariation disease BEFREE K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors. 18663146 2008
CUI: C0079748
Disease: Precursor cell lymphoblastic lymphoma
Precursor cell lymphoblastic lymphoma 		0.040 GeneticVariation disease BEFREE Clinical impact of NOTCH1 and/or FBXW7 mutations, FLASH deletion, and TCR status in pediatric T-cell lymphoblastic lymphoma. 22547598 2012
CUI: C0079748
Disease: Precursor cell lymphoblastic lymphoma
Precursor cell lymphoblastic lymphoma 		0.040 GeneticVariation disease BEFREE A novel TRB@/NOTCH1 fusion gene in T-cell lymphoblastic lymphoma with t(7;9)(q34;q34). 23033986 2013
CUI: C0079748
Disease: Precursor cell lymphoblastic lymphoma
Precursor cell lymphoblastic lymphoma 		0.040 Biomarker disease BEFREE Multivariate analysis identified serum lactate dehydrogenase level and the NOTCH1/FBXW7/RAS/PTEN oncogene (a four-gene oncogenetic classifier) status but not positron emission tomography or hematopoietic stem cell transplant as independent prognostic factors for outcome in T-LL. 26644537 2016