|
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
MicroRNA‑495 targets Notch1 to prohibit cell proliferation and invasion in oral squamous cell carcinoma.
|
30387817 |
2019 |
|
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Notch 1/2 genes play tumor-suppressing functions in squamous cell carcinoma (SCC), a very common malignancy in skin and internal organs.
|
29757189 |
2018 |
|
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Prognostic implication of NOTCH1 in early stage oral squamous cell cancer with occult metastases.
|
28866747 |
2018 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A novel Notch1 missense mutation (C1133Y) in the Abruptex domain exhibits enhanced proliferation and invasion in oral squamous cell carcinoma.
|
29321718 |
2018 |
|
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Expression and oncogenic properties of membranous Notch1 in oral leukoplakia and oral squamous cell carcinoma.
|
29620248 |
2018 |
|
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We found that mRNA high expression level of Notch1 was associated with better overall survival (OS) for all NSCLC patients, hazard ratio (HR) 0.78 (0.69-0.89), p=0.00019, better OS in adenocarcinoma (Ade) patients, HR 0.59 (0.46-0.75), p=1.5e-05, as well as in squamous cell carcinoma (SCC) patients, HR 0.78 (0.62-0.99), p=0.044. mRNA high expression levels of Notch2 and Notch3 were associated with worsen OS for all NSCLC patients, as well as in Ade, but not in SCC patients. mRNA high expression level of Notch4 was not found to be associated with to OS for all NSCLC patients.
|
28061457 |
2017 |
|
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Notch1 in oral squamous cell carcinoma.
|
27615693 |
2017 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Interaction Between Rare Variants in NOTCH1 and Betel Quid Chewing in Oral Squamous Cell Carcinoma.
|
28910158 |
2017 |
|
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Otherwise, patients with squamous cell carcinoma had relative higher expression of Notch1 and Notch3 expression (<i>p</i> = 0.014 and <i>p</i> = 0.032, respectively).
|
28607605 |
2017 |
|
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our systematic analysis of proteins and glycoproteins demonstrates changes of protein and glycoprotein relative abundance in SqCC (TP53, U2AF1, and RXR) and in ADC (SMARCA4, NOTCH1, PTEN, and MST1).
|
28814946 |
2017 |
|
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Expression of p53, p16, cyclin D1, epidermal growth factor receptor and Notch1 in patients with temporal bone squamous cell carcinoma.
|
27488595 |
2017 |
|
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Moreover, Notch1 is activated in a small subset of SCC cells at the invasive tumor front and predicts for poor prognosis of esophageal SCC, shedding light upon the tumor promoting oncogenic aspect of Notch1 in SCC.
|
29170450 |
2017 |
|
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
A mutation in NOTCH1 ligand binding region detected in patients with oral squamous cell carcinoma reduces NOTCH1 oncogenic effect.
|
28791383 |
2017 |
|
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
High fractions of each of these tumor types were positive for NICD1 in a subset of cells, particularly in basaloid squamous cell carcinomas; however, sequencing of basaloid squamous cell carcinomas failed to identify NOTCH1 mutations.
|
28914715 |
2017 |
|
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma.
|
27923803 |
2017 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Moreover, based on accumulating structural information of the NOTCH receptor, the functional consequences of NOTCH1 gene mutations identified from diverse SCCs are analyzed, emphasizing loss of function of Notch in these cancers.
|
27228302 |
2016 |
|
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.
|
25759215 |
2015 |
|
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Epidermal growth factor receptor inhibition reduces angiogenesis via hypoxia-inducible factor-1α and Notch1 in head neck squamous cell carcinoma.
|
25723392 |
2015 |
|
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
This molecular circuitry may inform distinct cell fate decisions to Notch1 in epithelial tissues, where carcinomas such as SCC arise.
|
24525741 |
2014 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Frequent mutations in NOTCH1 ligand-binding regions in Japanese oral squamous cell carcinoma.
|
25234595 |
2014 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Downmodulation or loss-of-function mutations of the gene encoding NOTCH1 are associated with dysfunctional squamous cell differentiation and development of squamous cell carcinoma (SCC) in skin and internal organs.
|
24743148 |
2014 |
|
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We used small interfering RNA (siRNA) technology to down-regulate the expression of Notch1 in small cell lung carcinoma (SCLC) cells; H69AR and SBC-3, as well as in non-small cell lung carcinoma (NSCLC) cells; A549 adenocarcinoma (ADC) and H2170 squamous cell carcinoma (SCC).
|
24888228 |
2014 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Common and complex Notch1 mutations in Chinese oral squamous cell carcinoma.
|
24277457 |
2014 |
|
Squamous cell carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We conclude that Notch1 expression is associated with cell aggressiveness and 5-FU drug resistance in human esophageal squamous cell carcinoma cell lines in vitro and is significantly associated with a poor survival in human esophageal squamous cell carcinomas.
|
23409141 |
2013 |
|
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Exome sequencing (n=50) and recurrence testing (n=60) reveals that some significantly and frequently altered genes are specific to OSCC-GB (USP9X, MLL4, ARID2, UNC13C and TRPM3), while some others are shared with HNSCC (for example, TP53, FAT1, CASP8, HRAS and NOTCH1).
|
24292195 |
2013 |