NOTCH1, notch receptor 1, 4851

N. diseases: 693; N. variants: 64
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.070 Biomarker disease BEFREE Our results demonstrate the importance of MLK3 in cervical cancer progression via modulating the Notch-1/autophagy network, and suggest that MLK3 is a promising therapeutic target for cervical cancer. 31192472 2019
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.070 Biomarker disease BEFREE The aim of this study was to investigate the effect of human umbilical vein endothelial cells on epithelial-to-mesenchymal transition of the cervical cancer cell line SiHa by studying the Notch1/lysyl oxidase (LOX)/SNAIL1 pathway. 31205475 2019
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.070 Biomarker disease BEFREE Notch1 inhibition enhances DNA damage induced by cisplatin in cervical cancer. 30690027 2019
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.070 Biomarker disease BEFREE The present data proved the over-expression of Notch1/JAGD1 and its association with tumor progression in human cervical cancer, which might be a potential valuable biomarker for cervical cancer and further studies need. 25842263 2015
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.070 Biomarker disease BEFREE CD66 and Notch1 were studied in clinical specimens and explants of human cervical cancer, including specimens grown in a pathophysiologically relevant murine model. 21646470 2011
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.070 AlteredExpression disease BEFREE Knockdown of p63 caused upregulation of Notch1 expression and marked reduction in proliferation and clonogenicity of both normal human keratinocytes and cervical cancer cell lines overexpressing DeltaNp63alpha. 20442293 2010
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.070 AlteredExpression disease BEFREE Features of Notch1 activation as measured by intracellular Notch1, high levels of Jagged1, Hes1 and Cdk9 were paralleled by nuclear translocation of both NF-kappaB p50 and p65 with target gene expression (IkappaB-alpha, Bcl-2, and CyclinD1) in human cervical cancer sections. 17098279 2007