|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results support the role of aberrant chromatin accessibility and consequent oncogenic <i>MYC</i> enhancer activation in NOTCH1-induced T-ALL.<i>This article is highlighted in the In This Issue feature, p. 1631</i>.
|
31519704 |
2019 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here we studied the phenotype of Per LAMs, their subpopulations in Notch1-induced acute lymphoblastic leukemia mice and compared with LAMs from BM or spleen in the same model.
|
27888718 |
2017 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The five most frequently mutated genes in T-ALL are NOTCH1, JAK3, FBXW7, FAT1, and NRAS.
|
28245838 |
2017 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor.
|
27229929 |
2016 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
LEF1 high expression is also associated with high mutation rate of Notch1 and JAK1 in T-ALL.
|
25942645 |
2015 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Forty-two somatic Notch1 mutations, including 7 nonsense mutations and 11 mutations within the domain commonly harboring potential activating mutations in acute lymphoblastic leukemia, were detected in 22 (43%) of the 51 Chinese OSCC tumors.
|
24277457 |
2014 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.
|
25194570 |
2014 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mechanistically, loss of SH2B3 increases Janus kinase-signal transducer and activator of transcription signaling, promotes lymphoid cell proliferation, and accelerates leukemia development in a mouse model of NOTCH1-induced ALL.
|
23908464 |
2013 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Two T-lymphoblastic leukemia (T-ALL) cell lines and two acute myeloblastic leukemia (AML) cell lines were transfected with siRNAs targeting NOTCH1 and NOTCH2.
|
24122995 |
2013 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, gain-of-function mutations or cryptic transcription initiation of the Notch1 gene have been frequently found in both human and mouse T-ALL.
|
22393458 |
2012 |
|
Acute lymphocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, expression of Notch1, an essential gene for developing hematological cells and T-ALL, was found to be negatively correlated with β-arrestin1 in ALL.
|
21479985 |
2011 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia.
|
21642962 |
2011 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
T-cell lymphoblastic leukemia in early childhood presents NOTCH1 mutations and MLL rearrangements.
|
19631984 |
2010 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
New therapeutic targets, such as CD22 in precusor B-cell ALL and mutations in NOTCH1 in T-cell ALL, are being exploited in clinical trials.
|
19792972 |
2009 |
|
Acute lymphocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To further investigate the molecular mechanisms underlying proliferation suppression and apoptosis and explore effective downstream target genes, we used RNA interference (RNAi) technology to down-regulate the expression of Notch-1 in GSIs-resistant T-ALL cell lines.
|
19091404 |
2009 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here we have investigated the prognostic impact of mutations in the NOTCH1 pathway, in particular, the NOTCH1 and FBXW7 genes, in a large cohort of adult patients with T-lymphoblastic leukemia (n=126).
|
19794083 |
2009 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using parallel studies in T cell progenitors and established T-ALL lines we have demonstrated that the NFkappaB signaling pathway is targeted and induced by Notch1 activation.
|
17329966 |
2007 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Oncogenic Notch1 mutations are found in most T-lineage acute lymphoblastic leukemias in humans and T-cell lymphomas in mice.
|
17585052 |
2007 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results show that the CUTLL1 cell line has a strong dependence on NOTCH1 signaling for proliferation and survival and supports that T-ALL patients whose tumors harbor t(7;9) should be included in clinical trials testing the therapeutic efficacy NOTCH1 inhibition with GSIs.
|
16688224 |
2006 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
NOTCH1 pathway activation represents a common feature of T-ALL when compared to acute myelogenous leukemia (AML) and B-cell precursor acute lymphoblastic leukemia.
|
15694671 |
2005 |