|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In OLP there were changes in stem cell markers as component of integrin complexes α6 and β1 integrin increased along with increase of melanoma-associated chondroitin sulphate proteoglycan (MCSP) and decreased of notch1 (N1) and keratin 15 (K15).
|
29460532 |
2019 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The amounts of CD271<sup>+</sup> MIC regulated by MSC-DF carrying high or low Notch1 pathway activity is well correlated with capability of melanoma metastasis, supporting that melanoma metastasis is MIC-mediated.
|
30941836 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among them, CCL5, IL6 and IL8, or MIP2 in mouse, were consistently reduced by Notch1 depletion in several human and mouse melanoma cell lines.
|
30036609 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The γ‑secretase inhibitor (GSI) was used for NOTCH1 inhibition and recombinant human (rh)TGF‑β was used for melanoma cell stimulation.
|
29620159 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the basis of these statements, the present study aimed to investigate the possible association between N-cadherin and Notch1 presence in primary cutaneous melanomas and lymph node metastases.
|
28828681 |
2017 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
EC N1ICD expression in melanoma correlated with shorter progression-free survival.
|
28238683 |
2017 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Blockade or genetic ablation of Notch1 and mitogen-activated protein kinase pathways abolishes melanoma cell migration and angiogenesis.
|
27476721 |
2016 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we uncover the Notch1 pathway as a molecular determinant that selectively controls the regulatory role of MSC-DF in melanoma metastasis.
|
27813493 |
2016 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We show that active Notch1 (Notch1(NIC)) and active (phosphorylated) ERBB3 and ERBB2 correlate significantly and are similarly expressed in both mutated and wild-type BRAF melanomas, suggesting these receptors are co-reactivated in melanoma to promote survival.
|
26967479 |
2016 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, the data highlight a novel mechanism of activation of Notch1 in melanoma cells and identify Notch1 as a new MT1-MMP substrate that plays important biological roles in melanoma.
|
24492617 |
2014 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the other end, addition of recombinant NRG1 can partially restore melanoma cell growth that is inhibited by Notch1 ablation.
|
22249266 |
2012 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Taken together, these findings demonstrate that Notch1 is a key effector of both Akt and hypoxia in melanoma development and identify the Notch signaling pathway as a potential therapeutic target in melanoma treatment.
|
18924608 |
2008 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings demonstrate that Notch1 is a key effector of both Akt and hypoxia in melanoma development and identify the Notch signaling pathway as a potential therapeutic target in melanoma treatment.
|
18924608 |
2008 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Constitutive activation of Notch1 by ectopic expression of the Notch1 intracellular domain enables VGP primary melanoma cell lines to proliferate in a serum-independent and growth factor-independent manner in vitro and to grow more aggressively with metastatic activity in vivo.
|
16618740 |
2006 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Furthermore, the oncogenic effect of Notch1 on primary melanoma cells was mediated by beta-catenin, which was upregulated following Notch1 activation.
|
16239965 |
2005 |