NOTCH1, notch receptor 1, 4851

N. diseases: 693; N. variants: 64
Disease: Acute leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.050 GeneticVariation disease BEFREE NOTCH1 mutation in a female with myeloid/NK cell precursor acute leukemia. 20730882 2010
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.050 GeneticVariation disease BEFREE The ETV6-NCOA2 fusion may define a novel subgroup of acute leukemia with T-lymphoid and myeloid features, which is associated with a high prevalence of NOTCH1 mutations. 18281529 2008
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.050 AlteredExpression disease BEFREE These results demonstrated that overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induces acute leukemia in a transgenic model for CML. 18193087 2008
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.050 Biomarker disease BEFREE Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias. 18184405 2007
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.050 Biomarker disease BEFREE Truncation of Notch1 has been shown to cause a subtype of acute leukemia, and activation of Notch4 has been associated with mammary and salivary gland carcinomas of mice. 12539049 2003