NOTCH1, notch receptor 1, 4851

N. diseases: 693; N. variants: 64
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.060 AlteredExpression disease BEFREE The NOTCH1 inhibitor Crenigacestat (TargetMol, T3633) repressed LIF-mediated activation of the stemness-related genes in osteosarcoma patient-derived primary tissues. 31615908 2020
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.060 Biomarker disease BEFREE In this study, to further evaluate the role of hypoxia and Notch1 on drug resistance of OS, we investigated the influence of inhibiting Notch1 pathway by Notch1 small interference RNA (siRNA) on human MG-63 OS cells in hypoxia. 27468877 2016
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.060 Biomarker disease BEFREE Furthermore, we identified Notch1 and lymphoid enhancer-binding factor 1 (LEF1) as target genes of miR-34c in OS cells and demonstrated that Notch1 and LEF1 have a major role in the effects of miR-34c on OS cell chemosensitivity and metastasis. 24802328 2014
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.060 AlteredExpression disease BEFREE Our data provide the first evidence that the downregulation of Notch-1 and reexpression of miRNAs by DATS may be an effective approach for the treatment of osteosarcoma. 23430952 2013
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.060 AlteredExpression disease BEFREE Our data provide the first evidence that the downregulation of Notch-1 by curcumin may be an effective approach for the treatment of osteosarcoma. 22521131 2012
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.060 AlteredExpression disease BEFREE Overexpression of NOTCH1 is associated with osteosarcoma, and overexpression of NOTCH3 or JAGGED1 in breast cancer cells favors the formation of osteolytic bone metastasis. 22002679 2012