Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE We found that CD133, NANOG, and NOTCH1 were significantly associated with lymph node metastasis, and NOTCH1 was also significantly associated with depth of invasion and locoregional recurrence. 28866747 2018
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE The Notch1 expression in CRC tissues was significantly higher than that in normal tissues statistically (OR: 15.46; 95% CI: 8.11-29.45; p = 0.003), and were associated with lymph node metastasis, tumor stage, depth of infiltration and histological differentiation. 28984154 2017
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE Moreover, this study highlighted that a concomitant high expression of N-cadherin and Notch1, both in primary lesions and in lymph node metastases, predicts an adverse clinical outcome in melanoma patients. 28828681 2017
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE Lower positive expression rate of RUNX3 and higher positive expression rate of Notch1 and Jagged 1 were observed in CRC tissues than those in normal adjacent tissues with a negative correlation, and the expression levels were associated with the differentiation degree, TNM staging, lymph node metastasis and tumor invasion depth (all P<0.05). 28498402 2017
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE Notch1 protein expression was significant positively correlated with lymph node metastasis, pathological grades, and TNM stages of IDC. 26971121 2016
Secondary malignant neoplasm of lymph node
0.100 Biomarker disease BEFREE The positive rate of Notch1 was higher in lymph node metastases positive cases (χ(2) =7.30, P<0.01). 26764364 2016
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE In PCa and lymph node metastasis, expression of SOX2 and NOTCH1 was highly related to that of SNAI2.In conclusion, I. SNAI2 silencing in PCa may turn-off the expression of NED markers and pluripotency genes, while turning-on that of specific metastasis-suppressors, II. 25686823 2015
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE The meta-analysis indicated that higher expression of Notch1 was associated with greater possibility of lymph node metastasis and higher TNM stages. 25996086 2015
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE NOTCH1 expression was associated with lymph node metastasis. 26394830 2015
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation disease BEFREE Multivariate analysis showed that both Notch1 mutation and lymph node metastasis are independent prognostic factors in the patient population (P = 0.001). 24277457 2014
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE By statistical analyses, it was observed that negative Notch-1 expression was significantly associated with advanced clinical stage (P = 0.001) and lymph node metastasis (P = 0.026) in LAD patients. 24423157 2013
Secondary malignant neoplasm of lymph node
0.100 Biomarker disease BEFREE Notch1 receptor may be a predictor of lymph node metastasis and may be related to poor prognostic markers in patients with PTC. 22118425 2012
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE (Mech Dev, 98, 2000, 95) Notch 1-4 are up-regulated in NSCLC tissues and Notch 1, 2 are positively correlated with lymph node metastasis, (Proc Natl Acad Sci U S A, 106, 2009, 22293) DAPT treatment could inhibit NRSP and induce apoptosis, with a marked increase in cleaved PARP, decreases in XIAP and Survivin proteins and concomitant release of Smac, EndoG, and AIF from mitochondria, indicating that inhibiting NRSP by DAPT triggers caspase-dependent and caspase-independent apoptosis. 22583356 2012
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE Chi-square tests revealed that NF-κB and Notch1 expression in ESCC tissues were significant associated with lymph node metastasis, LVD, podoplanin, and VEGF-C expression. 21939555 2011
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE Notch1 and jagged1 were significantly more highly expressed in lymph node metastasis-positive tongue carcinoma (χ² = 6.108, P = 0.013; χ² = 7.354, P = 0.025). 20819128 2011