Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the prognostic value of NOTCH1 associated with lncRNA in T cell acute lymphoblastic leukemia 1 (NALT1) in GC and the mechanism of its involvement in GC invasion and metastasis.
|
31802831 |
2019 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Notch1 overexpression in GC and CRC suggested aggressive biological behaviors, and Notch1 may be a biomarker in digestive tract cancers.
|
30043645 |
2018 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the reversing effects of NOTCH1 inhibitor LY3039478 on cancer of the stomach's drug-resistance cells SGC7901/DDP and its relevant mechanism.
|
30024600 |
2018 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, the combination of doxorubicin with Notch1 siRNA is a potential strategy for the treatment of GC.
|
30127866 |
2018 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further studies on miR-92a and EP4/Notch1 may provide a new treatment strategy for gastric cancer.
|
29849934 |
2018 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The function of Notch1 intracellular domain in the differentiation of gastric cancer.
|
29616098 |
2018 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Combining Notch1 inhibitors with crocodile choline might represent a novel approach for gastric cancer.
|
28347224 |
2017 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that RKIP activity in cervical and stomach cancer is inversely correlated with endogenous levels of the Notch1 intracellular domain (NICD), which stimulates the epithelial to mesenchymal transition (EMT) and metastasis.
|
26716415 |
2016 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Conversely, blocking Notch1 using a γ-secretase inhibitor up-regulated miR-124 expression, inhibited GC cell growth, migration and invasion.
|
26612211 |
2016 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
First, we found that Notch 1 was highly expressed in the cisplatin-resistant gastric cancer cell lines SGC7901/DDP and BGC823/DDP cells.
|
25763542 |
2015 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Notch1 has an anti-cancer role in gastric cancer.
|
24113181 |
2013 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Previous study showed that the activated Notch1 receptor promoted gastric cancer progression through cyclooxygenase-2 (COX-2).
|
21976141 |
2012 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have already reported that the epigenetic regulation of the Notch ligand DLL1 controls Notch1 signaling activation in gastric cancer, and that Notch1 inhibition is associated with the diffuse type of gastric cancer.
|
23085543 |
2012 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Activation of the Notch1/STAT3/Twist signaling axis promotes gastric cancer progression.
|
22581828 |
2012 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the specific role of the Notch1 ligand DLL1 in GC has not yet been elucidated.
|
22249198 |
2011 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Notch1/2/3 and Hes1 were expressed in most GC cell lines as well as normal gastric mucosae, while Hes2/3 were expressed in neither these cell lines nor the normal stomach.
|
16647036 |
2006 |