NOTCH1, notch receptor 1, 4851

N. diseases: 693; N. variants: 64
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker disease BEFREE To investigate the prognostic value of NOTCH1 associated with lncRNA in T cell acute lymphoblastic leukemia 1 (NALT1) in GC and the mechanism of its involvement in GC invasion and metastasis. 31802831 2019
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker disease BEFREE Notch1 overexpression in GC and CRC suggested aggressive biological behaviors, and Notch1 may be a biomarker in digestive tract cancers. 30043645 2018
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker disease BEFREE To investigate the reversing effects of NOTCH1 inhibitor LY3039478 on cancer of the stomach's drug-resistance cells SGC7901/DDP and its relevant mechanism. 30024600 2018
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 AlteredExpression disease BEFREE Thus, the combination of doxorubicin with Notch1 siRNA is a potential strategy for the treatment of GC. 30127866 2018
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker disease BEFREE Further studies on miR-92a and EP4/Notch1 may provide a new treatment strategy for gastric cancer. 29849934 2018
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker disease BEFREE The function of Notch1 intracellular domain in the differentiation of gastric cancer. 29616098 2018
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker disease BEFREE Combining Notch1 inhibitors with crocodile choline might represent a novel approach for gastric cancer. 28347224 2017
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 AlteredExpression disease BEFREE Here, we show that RKIP activity in cervical and stomach cancer is inversely correlated with endogenous levels of the Notch1 intracellular domain (NICD), which stimulates the epithelial to mesenchymal transition (EMT) and metastasis. 26716415 2016
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 AlteredExpression disease BEFREE Conversely, blocking Notch1 using a γ-secretase inhibitor up-regulated miR-124 expression, inhibited GC cell growth, migration and invasion. 26612211 2016
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 AlteredExpression disease BEFREE First, we found that Notch 1 was highly expressed in the cisplatin-resistant gastric cancer cell lines SGC7901/DDP and BGC823/DDP cells. 25763542 2015
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker disease BEFREE Notch1 has an anti-cancer role in gastric cancer. 24113181 2013
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 AlteredExpression disease BEFREE Previous study showed that the activated Notch1 receptor promoted gastric cancer progression through cyclooxygenase-2 (COX-2). 21976141 2012
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker disease BEFREE We have already reported that the epigenetic regulation of the Notch ligand DLL1 controls Notch1 signaling activation in gastric cancer, and that Notch1 inhibition is associated with the diffuse type of gastric cancer. 23085543 2012
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker disease BEFREE Activation of the Notch1/STAT3/Twist signaling axis promotes gastric cancer progression. 22581828 2012
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker disease BEFREE However, the specific role of the Notch1 ligand DLL1 in GC has not yet been elucidated. 22249198 2011
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 AlteredExpression disease BEFREE Notch1/2/3 and Hes1 were expressed in most GC cell lines as well as normal gastric mucosae, while Hes2/3 were expressed in neither these cell lines nor the normal stomach. 16647036 2006