NPY, neuropeptide Y, 4852

N. diseases: 381; N. variants: 12
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.380 GeneticVariation group BEFREE The restriction fragment length polymorphisms (RFLPs) associated with neuropeptide Y (NPY) and somatostatin loci were used to assess the possibility of linkage to a locus for affective disorder (AD). 2894462 1987
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.380 AlteredExpression group BEFREE These functions of NPY, in addition to the peptide's regulation of disease states, suggest that modulation of the activity of the NPY system <i>via</i> receptor agonists/antagonists may be a putative treatment mechanism in affective disorders as well as alcohol use disorders. 28824541 2017
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.380 Biomarker group PSYGENET Emotional behavior in aged neuropeptide Y (NPY) Y2 knockout mice. 16691011 2006
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.380 AlteredExpression group BEFREE To our knowledge, these results provide the first evidence in humans linking NPY with salience sensitivity of the NAc, raising the possibility that individual differences in NPY expression moderate the risk for disorders of mesoaccumbal function such as addictions and mood disorders. 30337638 2019
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.380 Biomarker group BEFREE With this in mind, researchers suggested the involvement of NPY as well as the Y(1) and Y(2) receptors in affective disorders. 19782662 2010
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.380 Biomarker group BEFREE For example, NPY is consistently involved in anxiety-related behaviors and there is increasing support for a role of this peptide in mood disorders such as depression. 16611091 2006
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.380 Biomarker group PSYGENET The results confirmed a major role for hippocampal and hypothalamic NPY system in the pathophysiology of mood disorders. 19846047 2010
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.380 Biomarker group PSYGENET A wealth of data indicates that neuropeptides, e.g., NPY, CRH, somatostatin, tachykinins and CGRP play a role in affective disorders and alcohol use/abuse. 17572454 2007
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.380 Biomarker group PSYGENET Neuropeptide Y (NPY) has been associated with stress reactivity in affective disorders and is most densely expressed in the amygdala. 23482625 2014
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.380 Biomarker group BEFREE The potential role of altered HPA axis, epigenetics, NPY, BDNF, neurosteroid biosynthesis, the endocannabinoid system, and their function as biomarkers for mood disorders is discussed. 30394136 2018
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.380 Biomarker group PSYGENET With this in mind, researchers suggested the involvement of NPY as well as the Y(1) and Y(2) receptors in affective disorders. 19782662 2010
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.380 Biomarker group BEFREE It has been hypothesized that the neuropeptide Y (NPY) system is involved in the pathogenesis of mood disorder. 11377922 2001
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.380 Biomarker group BEFREE Neuropeptide Y (NPY) has been associated with stress reactivity in affective disorders and is most densely expressed in the amygdala. 23482625 2014