Mood Disorders
|
0.380 |
GeneticVariation
|
group |
BEFREE |
The restriction fragment length polymorphisms (RFLPs) associated with neuropeptide Y (NPY) and somatostatin loci were used to assess the possibility of linkage to a locus for affective disorder (AD).
|
2894462 |
1987 |
Mood Disorders
|
0.380 |
AlteredExpression
|
group |
BEFREE |
These functions of NPY, in addition to the peptide's regulation of disease states, suggest that modulation of the activity of the NPY system <i>via</i> receptor agonists/antagonists may be a putative treatment mechanism in affective disorders as well as alcohol use disorders.
|
28824541 |
2017 |
Mood Disorders
|
0.380 |
Biomarker
|
group |
PSYGENET |
Emotional behavior in aged neuropeptide Y (NPY) Y2 knockout mice.
|
16691011 |
2006 |
Mood Disorders
|
0.380 |
AlteredExpression
|
group |
BEFREE |
To our knowledge, these results provide the first evidence in humans linking NPY with salience sensitivity of the NAc, raising the possibility that individual differences in NPY expression moderate the risk for disorders of mesoaccumbal function such as addictions and mood disorders.
|
30337638 |
2019 |
Mood Disorders
|
0.380 |
Biomarker
|
group |
BEFREE |
With this in mind, researchers suggested the involvement of NPY as well as the Y(1) and Y(2) receptors in affective disorders.
|
19782662 |
2010 |
Mood Disorders
|
0.380 |
Biomarker
|
group |
BEFREE |
For example, NPY is consistently involved in anxiety-related behaviors and there is increasing support for a role of this peptide in mood disorders such as depression.
|
16611091 |
2006 |
Mood Disorders
|
0.380 |
Biomarker
|
group |
PSYGENET |
The results confirmed a major role for hippocampal and hypothalamic NPY system in the pathophysiology of mood disorders.
|
19846047 |
2010 |
Mood Disorders
|
0.380 |
Biomarker
|
group |
PSYGENET |
A wealth of data indicates that neuropeptides, e.g., NPY, CRH, somatostatin, tachykinins and CGRP play a role in affective disorders and alcohol use/abuse.
|
17572454 |
2007 |
Mood Disorders
|
0.380 |
Biomarker
|
group |
PSYGENET |
Neuropeptide Y (NPY) has been associated with stress reactivity in affective disorders and is most densely expressed in the amygdala.
|
23482625 |
2014 |
Mood Disorders
|
0.380 |
Biomarker
|
group |
BEFREE |
The potential role of altered HPA axis, epigenetics, NPY, BDNF, neurosteroid biosynthesis, the endocannabinoid system, and their function as biomarkers for mood disorders is discussed.
|
30394136 |
2018 |
Mood Disorders
|
0.380 |
Biomarker
|
group |
PSYGENET |
With this in mind, researchers suggested the involvement of NPY as well as the Y(1) and Y(2) receptors in affective disorders.
|
19782662 |
2010 |
Mood Disorders
|
0.380 |
Biomarker
|
group |
BEFREE |
It has been hypothesized that the neuropeptide Y (NPY) system is involved in the pathogenesis of mood disorder.
|
11377922 |
2001 |
Mood Disorders
|
0.380 |
Biomarker
|
group |
BEFREE |
Neuropeptide Y (NPY) has been associated with stress reactivity in affective disorders and is most densely expressed in the amygdala.
|
23482625 |
2014 |