NPY, neuropeptide Y, 4852

N. diseases: 381; N. variants: 12
Disease: Major Depressive Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 GeneticVariation disease BEFREE Several promising genes, such as the COMT (catechol-O-methyltransferase) gene, the serotonin transporter gene (SLC6A4), and neuropeptide Y (NPY) suggest gene × environment interaction between genetic variants, childhood adversity, and the occurrence of PTSD and MDD, indicating an impact of these genes on resilience. 31583809 2020
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 Biomarker disease BEFREE Both NPY and CGRP were higher in PD patients with comorbid depression compared to MDD patients. 28659833 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 Biomarker disease PSYGENET A series of statistical methods was carried out to investigate the correlation between the NPY gene SNP and MDD. 23468908 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 GeneticVariation disease BEFREE A series of statistical methods was carried out to investigate the correlation between the NPY gene SNP and MDD. 23468908 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 GeneticVariation disease BEFREE To test this hypothesis, we compared plasma levels and affinities of NPY-reactive autoAbs between patients with major depression and healthy controls. 22365482 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 Biomarker disease PSYGENET To test this hypothesis, we compared plasma levels and affinities of NPY-reactive autoAbs between patients with major depression and healthy controls. 22365482 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 Biomarker disease PSYGENET Supporting studies in mutant mice models suggest a complex mechanism of low constitutive and activity-dependent BDNF function in MDD, particularly affecting SST/NPY-related GABA neurons, thus linking the neurotrophic and GABA hypotheses of depression. 21912391 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 Biomarker disease PSYGENET In the GAIN MDD study, two SNPs were associated with MDD: C5orf20 (rs12520799; P=0.038; odds ratio (OR) AT=1.10, 95% CI 0.95-1.29; OR TT=1.21, 95% confidence interval (CI) 1.01-1.47) and NPY (rs16139; P=0.034; OR C allele=0.73, 95% CI 0.55-0.97), constituting a direct replication of previously identified SNPs. 20351714 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 GeneticVariation disease BEFREE Among 44 individuals with MDD and 137 healthy controls, 152 (84%) had an NPY genotype classified as low, intermediate, or high expression according to previously established haplotype-based expression data. 21300944 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 GeneticVariation disease BEFREE In the GAIN MDD study, two SNPs were associated with MDD: C5orf20 (rs12520799; P=0.038; odds ratio (OR) AT=1.10, 95% CI 0.95-1.29; OR TT=1.21, 95% confidence interval (CI) 1.01-1.47) and NPY (rs16139; P=0.034; OR C allele=0.73, 95% CI 0.55-0.97), constituting a direct replication of previously identified SNPs. 20351714 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 Biomarker disease PSYGENET Among 44 individuals with MDD and 137 healthy controls, 152 (84%) had an NPY genotype classified as low, intermediate, or high expression according to previously established haplotype-based expression data. 21300944 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 Biomarker disease BEFREE Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism.J. Psychiatr.Res.38, 113-121). 19264362 2009
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 Biomarker disease BEFREE Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism. 14757324 2004