NOTCH3, notch receptor 3, 4854

N. diseases: 418; N. variants: 71
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.360 Biomarker group BEFREE The critical role of NOTCH3 in inducing an invasive phenotype and poor outcome was corroborated in unique TNBC cells resulting from a patient-derived brain metastasis (TNBC-M25) and in publicly available claudin-low breast tumor specimens collected from participants in the Molecular Taxonomy of Breast Cancer International Consortium database. 30180881 2018
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.360 Biomarker group BEFREE In the present study, we demonstrated that GSIs, such as MK-0752 and RO4929097, inhibit breast tumor growth, but increase the breast cancer stem cell (BCSC) population in Notch3-expressing breast cancer cells, in a process that is coupled with IL6 induction and is blocked by the IL6R antagonist Tocilizumab (TCZ). 29027990 2018
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.360 Biomarker group BEFREE Many of these genes were significantly coexpressed with NOTCH3 in neuroblastoma, as well as colon, kidney, ovary, and breast tumor series. 23649002 2013
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.360 Biomarker group CTD_human Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation. 21036696 2010
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.360 Biomarker group BEFREE Finally, NOTCH3 gene amplification was detected in a breast tumor cell line and one breast cancer tissue specimen even though the frequency of NOTCH3 gene amplification was low (<1%). 18339869 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.360 Biomarker group LHGDN Finally, NOTCH3 gene amplification was detected in a breast tumor cell line and one breast cancer tissue specimen even though the frequency of NOTCH3 gene amplification was low (<1%). 18339869 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.360 AlteredExpression group LHGDN A study on Notch signaling in human breast cancer. 17822320 2007
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.360 AlteredExpression group LHGDN p66Shc/Notch-3 interplay controls self-renewal and hypoxia survival in human stem/progenitor cells of the mammary gland expanded in vitro as mammospheres. 17158237 2007